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==Classification==
==Classification==
Delayed puberty is almost always due to physiologic exaggerated prolongation of puberty timing in boys, a condition called "constitutional delay of growth and puberty (CDGP)". Delayed puberty may sometimes has another pathophysiologies, however, the CDGP is the most common cause of delayed puberty in both boys and girls. The main classification of delayed puberty is as following:<ref name="PalmertDunkel2012">{{cite journal|last1=Palmert|first1=Mark R.|last2=Dunkel|first2=Leo|title=Delayed Puberty|journal=New England Journal of Medicine|volume=366|issue=5|year=2012|pages=443–453|issn=0028-4793|doi=10.1056/NEJMcp1109290}}</ref>
Delayed puberty is almost always due to [[physiologic]] exaggerated prolongation of [[puberty]] timing in boys, a condition called "[[Constitutional delay of puberty|constitutional delay of growth and puberty (CDGP)]]". Delayed puberty may sometimes has another [[Pathophysiology|pathophysiologies]], however, the [[Constitutional delay of puberty|CDGP]] is the most common cause of delayed [[puberty]] in both boys and girls. The main classification of delayed [[puberty]] is as following:<ref name="PalmertDunkel2012">{{cite journal|last1=Palmert|first1=Mark R.|last2=Dunkel|first2=Leo|title=Delayed Puberty|journal=New England Journal of Medicine|volume=366|issue=5|year=2012|pages=443–453|issn=0028-4793|doi=10.1056/NEJMcp1109290}}</ref>




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{{Family tree/end}}
{{Family tree/end}}
The differential diagnosis of CDGP can be divided into three main categories[http://www.nejm.org/doi/full/10.1056/NEJMcp1109290#ref7 7]: hypergonadotropic hypogonadism (characterized by elevated levels of luteinizing hormone and FSH owing to the lack of negative feedback from the gonads), permanent hypogonadotropic hypogonadism (characterized by low levels of luteinizing hormone and FSH owing to hypothalamic or pituitary disorders), and transient hypogonadotropic hypogonadism (functional hypogonadotropic hypogonadism), in which pubertal delay is caused by delayed maturation of the HPG axis secondary to an underlying condition


==References==
==References==

Revision as of 16:54, 29 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Classification

Delayed puberty is almost always due to physiologic exaggerated prolongation of puberty timing in boys, a condition called "constitutional delay of growth and puberty (CDGP)". Delayed puberty may sometimes has another pathophysiologies, however, the CDGP is the most common cause of delayed puberty in both boys and girls. The main classification of delayed puberty is as following:[1]


 
 
 
 
 
 
 
Delayed puberty
classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
LH, FSH, and GnRH
measurement
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Normal
 
 
 
 
 
 
 
Abnormal
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Constitutional delay of growth and puberty (CDGP)
 
 
LH and FSH decreased
GnRH increased
 
 
LH and FSH decreased
GnRH decreased
 
 
LH and FSH decreased
GnRH decreased
(transient)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hypergonadotropic hypogonadism
 
 
Permanent hypogonadotropic hypogonadism
 
 
Functional hypogonadotropic hypogonadism
 
 
 

References

  1. Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.

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