Prolactinoma natural history, complications, and prognosis: Difference between revisions
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*[[Tumor]] regrowth (after resection) | *[[Tumor]] regrowth (after resection) | ||
*[[Blindness]] | *[[Blindness]] | ||
*In [[pregnancy]], excessive [[estrogen]] may cause increased tumor growth | *In [[pregnancy]], excessive [[estrogen]] may cause increased [[tumor]] growth | ||
==Prognosis== | ==Prognosis== | ||
Revision as of 19:41, 30 August 2017
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Prolactinoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Anmol Pitliya, M.B.B.S. M.D.[2]Faizan Sheraz, M.D. [3]
Overview
If left untreated, 95% of cases of prolactinoma will not show any signs of growth during the first 4 to 6 years. Complications of prolactinoma include pituitary apoplexy and vision loss. Prognosis is generally excellent for cases of microprolactinoma.
Natural History
If left untreated, 95% of cases of prolactinoma will not show any signs of growth during the first 4 to 6 years.
Complications
Complications of prolactinoma include:
- Pituiary apoplexy[1]
- Pituitary apoplexy usually presents with sudden onset of excruciating headache, diplopia, and visual impairment.
- Headache is most common symptom and is usually associated with nausea and vomiting.
| Hemorrhage and/or infarction in prolactinoma | |||||||||||||||||||
| Rapid enlargement of tumor | |||||||||||||||||||
| Compression of sella and para sellar structures | |||||||||||||||||||
- Tumor regrowth (after resection)
- Blindness
- In pregnancy, excessive estrogen may cause increased tumor growth
Prognosis
- Prognosis is excellent for cases of microprolactinoma.
- Depending on the size of the tumor and the extent of tumor resection, the rate of recurrence may range from 20% to 50%.
- The majority of recurrent prolactinomas develop within the first 5 years.[2]
References
- ↑ Liu JK, Couldwell WT (2004). "Contemporary management of prolactinomas". Neurosurg Focus. 16 (4): E2. PMID 15191331.
- ↑ http://www.niddk.nih.gov/health-information/health-topics/endocrine/prolactinoma/Pages/fact-sheet.aspx