Incidentaloma physical examination: Difference between revisions
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The presence of [finding(s)] on physical examination is highly suggestive of [disease name]. | The presence of [finding(s)] on physical examination is highly suggestive of [disease name]. | ||
==Physical Examination== | ==Physical Examination== | ||
===Appearance of the Patient=== | ===Appearance of the Patient=== | ||
*Patients with | * Patients may appear tired, weak, [[diaphoretic]] and [[anxious]].<sup>[[Pheochromocytoma physical examination#cite note-pmid8325290-1|[1]]]</sup> | ||
* Patients may appear quite well if the [[disease]] is [[asymptomatic]]. | |||
* Patients may appear [[Flushing|flushed]] due to associated increase in [[erythropoietin]] secretion.<sup>[[Pheochromocytoma physical examination#cite note-pmid7567437-2|[2]]]</sup> | |||
* Patients may appear [[obese]] due to associated type2 [[diabetes mellitus]] and [[Cushing's syndrome]].<sup>[[Pheochromocytoma physical examination#cite note-pmid12923403-3|[3]]]</sup> | |||
* Patients with Cushing's syndrome usually appears [[overweight]]. | |||
===Vital Signs=== | ===Vital Signs=== | ||
* [[Tachycardia]] with a regular pulse. Irregular pulse may occurr in [[supraventricular tachycardia]]. | |||
* [[Tachypnea]] if [[malignant]] secondaries are found in the [[lung]]. [[Dyspnea]] occurs in patients with complicated [[heart failure]] and [[Cardiomyopathy|cardiomyopathy.]] | |||
*[[ | * Rapid strong equal [[pulse]] | ||
*[[ | * High [[blood pressure]] with normal [[pulse pressure]] | ||
* [[Hypotension]] occurs due to fluid contraction | |||
* | * [[Hypertension]], due to [[Cortisol|cortisol's]] enhancement of [[epinephrine]]'s [[vasoconstrictive]] effect | ||
* | |||
===Skin=== | ===Skin=== | ||
*[[ | * [[Jaundice]] secondary to deranged [[liver]] function in case of [[metastasis]] to the [[liver]]. | ||
*[[ | * [[Hyperpigmentation]] - this is due to Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from [[Proopiomelanocortin|Proopiomelanocortin (POMC)]] | ||
* [[ | * [[Telangiectasia]] (dilation of capillaries) | ||
* | * Thinning of the skin (which causes [[easy bruising]]) | ||
* Purple or red [[striae]] (the weight gain in Cushing's stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs or breasts, proximal muscle weakness (hips, shoulders) | |||
* [[Hirsutism]] (facial male-pattern hair growth) | |||
===HEENT=== | ===HEENT=== | ||
* | * [[Facial flushing]] | ||
* | * [[Icterus|Scleral icterus]] in case of [[metastasis]] to the [[liver]] | ||
* [[MEN2]] patients associated with [[mucosal]] [[Neuroma|neuromas]] show multiple lips and tongue [[Neuroma|neuromas]]. | |||
* [[ | * [[Moon face|Moon-face]] is a medical sign where the face swells up into a rounded shape. It is often associated with [[Cushing's syndrome]], which has led to it being known as Cushingoid facies ("Cushings-like face"), or [[steroid]] treatment, which has led to the name steroid facies. | ||
*[[ | |||
===Neck=== | ===Neck=== | ||
*[[ | * Congested [[neck veins]] in patients with [[cardiomyopathy]]<sup>[[Pheochromocytoma physical examination#cite note-pmid19158054-4|[4]]]</sup> | ||
* Painless [[lymphadenopathy]] if [[malignant]] secondaries found in the neck (rapid increase in the size of the [[Lymph node|node]]. [[Prevalence]] of [[malignancy]] in [[Lymph node biopsy|lymph node biopsies]] performed is 60%<sup>[[Pheochromocytoma physical examination#cite note-pmid18888946-5|[5]]]</sup> | |||
*[[ | * [[Thyromegaly]]/[[thyroid]] [[nodules]] if [[Multiple endocrine neoplasia|MEN]] patients due to [[medullary thyroid cancer]].<sup>[[Pheochromocytoma physical examination#cite note-pmid258100472-6|[6]]]</sup> | ||
*[[Thyromegaly]] / thyroid nodules | * Growth of fat pads along the collar bone and on the back of the neck. | ||
===Lungs=== | ===Lungs=== | ||
* | * Asymmetric [[chest]] expansion / decreased [[chest]] expansion if [[malignant]] secondaries are found in the [[lung]]. | ||
===Heart=== | ===Heart=== | ||
* | * Chest [[tenderness]] upon [[palpation]] in [[MEN1]] patients due to [[hyperparathyroidism]]. | ||
* [[Palpation]]: [[Precordium|Precordial]] [[heave]] especially at apex due to [[left ventricular hypertrophy]] in long standing patients. | |||
* Auscultation: normal [[Heart sounds|S1]] and accentuated [[Heart sounds|S2]] due to high systemic resistance. | |||
*[[ | |||
*[[Heart sounds | |||
===Abdomen=== | ===Abdomen=== | ||
*[[Abdominal distention]] | * [[Abdominal distention]] in patients with [[primary hyperparathyroidism]] associated [[constipation]] or [[Hirschsprung's disease|Hirschsprung disease]]. | ||
*[[Abdominal tenderness]] | * [[Abdominal tenderness]] in the lower [[abdominal]] quadrants in [[Multiple endocrine neoplasia type 2|MEN2]] patients with [[Hirschsprung disease|Hirschsprung disease.]]<sup>[[Pheochromocytoma physical examination#cite note-pmid7491537-7|[7]]]</sup> | ||
* A palpable [[abdominal mass]] in the lower [[abdominal]] quadrant. | |||
*A | * [[Abdominal guarding|Guarding]] may be present. | ||
*Guarding | * [[Hepatomegaly]] if [[malignant]] secondaries found in [[liver]]. | ||
*[[Hepatomegaly]] | * [[Diarrhea]] caused by [[gastrointestinal]] secretion of fluid and [[Electrolyte|electrolytes]], and [[flushing]] in [[medullary thyroid cancer]] patients.<sup>[[Pheochromocytoma physical examination#cite note-pmid25810047-8|[8]]]</sup> | ||
* | |||
=== | ===Back === | ||
* | * Point [[tenderness]] in [[MEN1]] patients with [[hyperparathyroidism]] | ||
===Neuromuscular=== | ===Neuromuscular=== | ||
* | * [[Hyporeflexia]] due to low [[potassium]] level in [[Hyperaldosteronism|aldosternonma]] | ||
* [[Proximal]] [[muscle weakness]] bilaterally | |||
*Bilateral [[tremors]] | |||
* Proximal | |||
* | |||
===Extremities=== | ===Extremities=== | ||
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*[[Cyanosis]] | *[[Cyanosis]] | ||
*Pitting/non-pitting [[edema]] of the upper/lower extremities | *Pitting/non-pitting [[edema]] of the upper/lower extremities | ||
*Muscle atrophy | *[[Muscle atrophy]] | ||
*Fasciculations in the upper/lower extremity | *[[Fasciculations]] in the upper/lower extremity | ||
==References== | ==References== |
Revision as of 15:17, 31 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].
OR
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
The presence of [finding(s)] on physical examination is diagnostic of [disease name].
OR
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].
Physical Examination
Appearance of the Patient
- Patients may appear tired, weak, diaphoretic and anxious.[1]
- Patients may appear quite well if the disease is asymptomatic.
- Patients may appear flushed due to associated increase in erythropoietin secretion.[2]
- Patients may appear obese due to associated type2 diabetes mellitus and Cushing's syndrome.[3]
- Patients with Cushing's syndrome usually appears overweight.
Vital Signs
- Tachycardia with a regular pulse. Irregular pulse may occurr in supraventricular tachycardia.
- Tachypnea if malignant secondaries are found in the lung. Dyspnea occurs in patients with complicated heart failure and cardiomyopathy.
- Rapid strong equal pulse
- High blood pressure with normal pulse pressure
- Hypotension occurs due to fluid contraction
- Hypertension, due to cortisol's enhancement of epinephrine's vasoconstrictive effect
Skin
- Jaundice secondary to deranged liver function in case of metastasis to the liver.
- Hyperpigmentation - this is due to Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC)
- Telangiectasia (dilation of capillaries)
- Thinning of the skin (which causes easy bruising)
- Purple or red striae (the weight gain in Cushing's stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs or breasts, proximal muscle weakness (hips, shoulders)
- Hirsutism (facial male-pattern hair growth)
HEENT
- Facial flushing
- Scleral icterus in case of metastasis to the liver
- MEN2 patients associated with mucosal neuromas show multiple lips and tongue neuromas.
- Moon-face is a medical sign where the face swells up into a rounded shape. It is often associated with Cushing's syndrome, which has led to it being known as Cushingoid facies ("Cushings-like face"), or steroid treatment, which has led to the name steroid facies.
Neck
- Congested neck veins in patients with cardiomyopathy[4]
- Painless lymphadenopathy if malignant secondaries found in the neck (rapid increase in the size of the node. Prevalence of malignancy in lymph node biopsies performed is 60%[5]
- Thyromegaly/thyroid nodules if MEN patients due to medullary thyroid cancer.[6]
- Growth of fat pads along the collar bone and on the back of the neck.
Lungs
- Asymmetric chest expansion / decreased chest expansion if malignant secondaries are found in the lung.
Heart
- Chest tenderness upon palpation in MEN1 patients due to hyperparathyroidism.
- Palpation: Precordial heave especially at apex due to left ventricular hypertrophy in long standing patients.
- Auscultation: normal S1 and accentuated S2 due to high systemic resistance.
Abdomen
- Abdominal distention in patients with primary hyperparathyroidism associated constipation or Hirschsprung disease.
- Abdominal tenderness in the lower abdominal quadrants in MEN2 patients with Hirschsprung disease.[7]
- A palpable abdominal mass in the lower abdominal quadrant.
- Guarding may be present.
- Hepatomegaly if malignant secondaries found in liver.
- Diarrhea caused by gastrointestinal secretion of fluid and electrolytes, and flushing in medullary thyroid cancer patients.[8]
Back
- Point tenderness in MEN1 patients with hyperparathyroidism
Neuromuscular
- Hyporeflexia due to low potassium level in aldosternonma
- Proximal muscle weakness bilaterally
- Bilateral tremors
Extremities
- Clubbing
- Cyanosis
- Pitting/non-pitting edema of the upper/lower extremities
- Muscle atrophy
- Fasciculations in the upper/lower extremity