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| ==Medical Therapy== | | ==Medical Therapy== |
| *Patients with cretinism are treated with thyroid hormone replacement therapy. | | *Patients with cretinism are treated with thyroid hormone replacement therapy. |
| *Endocrine society recommended with the appropriate quick initiation of thyroid hormone replacement therapy.<ref name="pmid24446653">{{cite journal| author=Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G et al.| title=European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. | journal=J Clin Endocrinol Metab | year= 2014 | volume= 99 | issue= 2 | pages= 363-84 | pmid=24446653 | doi=10.1210/jc.2013-1891 | pmc=4207909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24446653 }}</ref> | | *Endocrine society recommended with the appropriate quick initiation of levothyroxine as the mainstay treatment of cretinism.<ref name="pmid24446653">{{cite journal| author=Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G et al.| title=European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. | journal=J Clin Endocrinol Metab | year= 2014 | volume= 99 | issue= 2 | pages= 363-84 | pmid=24446653 | doi=10.1210/jc.2013-1891 | pmc=4207909 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24446653 }}</ref> |
| ===Cretinism ===
| | * |
| | |
| * '''1 Stage 1 - Name of stage'''
| |
| ** 1.1 '''Specific Organ system involved 1'''
| |
| *** 1.1.1 '''Adult'''
| |
| **** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)'''
| |
| **** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
| |
| **** Preferred regimen (3): [[drug name]] 500 mg q12h for 14-21 days
| |
| **** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days
| |
| **** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
| |
| **** Alternative regimen (3): [[drug name]] 500 mg PO q6h for 14–21 days
| |
| *** 1.1.2 '''Pediatric'''
| |
| **** 1.1.2.1 (Specific population e.g. '''children < 8 years of age''')
| |
| ***** Preferred regimen (1): [[drug name]] 50 mg/kg PO per day q8h (maximum, 500 mg per dose)
| |
| ***** Preferred regimen (2): [[drug name]] 30 mg/kg PO per day in 2 divided doses (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (1): [[drug name]]10 mg/kg PO q6h (maximum, 500 mg per day)
| |
| ***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
| |
| ****1.1.2.2 (Specific population e.g. '<nowiki/>'''''children < 8 years of age'''''')
| |
| ***** Preferred regimen (1): [[drug name]] 4 mg/kg/day PO q12h（maximum, 100 mg per dose）
| |
| ***** Alternative regimen (1): [[drug name]] 10 mg/kg PO q6h (maximum, 500 mg per day)
| |
| ***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
| |
| ** 2.1 '''Specific Organ system involved 2'''
| |
| *** 2.1.1 '''Adult'''
| |
| **** Preferred regimen (1): [[drug name]] 500 mg PO q8h
| |
| *** 2.1.2 '''Pediatric'''
| |
| **** Preferred regimen (1): [[drug name]] 50 mg/kg/day PO q8h (maximum, 500 mg per dose)
| |
| | |
| * 2 '''Stage 2 - Name of stage'''
| |
| ** 2.1 '''Specific Organ system involved 1 '''
| |
| **: '''Note (1):'''
| |
| **: '''Note (2)''':
| |
| **: '''Note (3):'''
| |
| *** 2.1.1 '''Adult'''
| |
| **** Parenteral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
| |
| ***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
| |
| ***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
| |
| **** Oral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
| |
| ***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
| |
| ***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
| |
| ***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days
| |
| ***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
| |
| ***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
| |
| *** 2.1.2 '''Pediatric'''
| |
| **** Parenteral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
| |
| ***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
| |
| ***** Alternative regimen (2): [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day) '<nowiki/>'''''(Contraindications/specific instructions)''''''
| |
| **** Oral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days (maximum, 500 mg per dose) | |
| ***** Preferred regimen (2): [[drug name]] '''(for children aged ≥ 8 years)''' 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
| |
| ***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (1): [[drug name]] 10 mg/kg PO q6h 7–10 days (maximum, 500 mg per day)
| |
| ***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days (maximum,500 mg per dose)
| |
| ** 2.2 '<nowiki/>'''''Other Organ system involved 2''''''
| |
| **: '''Note (1):'''
| |
| **: '''Note (2)''':
| |
| **: '''Note (3):'''
| |
| *** 2.2.1 '''Adult'''
| |
| **** Parenteral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
| |
| ***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
| |
| ***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
| |
| **** Oral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
| |
| ***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
| |
| ***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
| |
| ***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days
| |
| ***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
| |
| ***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
| |
| *** 2.2.2 '''Pediatric'''
| |
| **** Parenteral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
| |
| ***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
| |
| ***** Alternative regimen (2): [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day)
| |
| **** Oral regimen
| |
| ***** Preferred regimen (1): [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days (maximum, 500 mg per dose)
| |
| ***** Preferred regimen (2): [[drug name]] 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
| |
| ***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (1): [[drug name]] 10 mg/kg PO q6h 7–10 days (maximum, 500 mg per day)
| |
| ***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days (maximum, 500 mg per dose)
| |
| ***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days (maximum,500 mg per dose)
| |
|
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| ==References== | | ==References== |