Delayed puberty epidemiology and demographics: Difference between revisions
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*The precise prevalence of delayed [[puberty]] is not known completely. | *The precise prevalence of delayed [[puberty]] is not known completely. | ||
*The whole [[puberty]] disorders prevalence is about 3000 cases per 100,000 individuals worldwide.<ref name="pmid19547638">{{cite journal |vauthors=Brämswig J, Dübbers A |title=Disorders of pubertal development |journal=Dtsch Arztebl Int |volume=106 |issue=17 |pages=295–303; quiz 304 |year=2009 |pmid=19547638 |pmc=2689583 |doi=10.3238/arztebl.2009.0295 |url=}}</ref> | *The whole [[puberty]] disorders prevalence is about 3000 cases per 100,000 individuals worldwide.<ref name="pmid19547638">{{cite journal |vauthors=Brämswig J, Dübbers A |title=Disorders of pubertal development |journal=Dtsch Arztebl Int |volume=106 |issue=17 |pages=295–303; quiz 304 |year=2009 |pmid=19547638 |pmc=2689583 |doi=10.3238/arztebl.2009.0295 |url=}}</ref> | ||
*The prevalence of primary [[amenorrhea]] in the US is < 0.1%.<ref name="pmid12836721">{{cite journal |vauthors=Timmreck LS, Reindollar RH |title=Contemporary issues in primary amenorrhea |journal=Obstet. Gynecol. Clin. North Am. |volume=30 |issue=2 |pages=287–302 |year=2003 |pmid=12836721 |doi= |url=}}</ref> | |||
===Case-fatality rate=== | ===Case-fatality rate=== | ||
*The case-fatality rate of delayed [[puberty]] is approximately zero. There is no reported case of [[mortality]] due to delayed [[puberty]]. | *The case-fatality rate of delayed [[puberty]] is approximately zero. There is no reported case of [[mortality]] due to delayed [[puberty]]. | ||
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===Race=== | ===Race=== | ||
*Delayed [[puberty]] usually affects individuals of all races, equally. | *Delayed [[puberty]] usually affects individuals of all races, equally. | ||
*Different races have different [[puberty]] onset ages; African-American girls [[menarche]] age are earlier than White girls', which is because of [[Body mass index|body mass index (BMI)]] difference between races.<ref name="pmid15541646">{{cite journal |vauthors=Styne DM |title=Puberty, obesity and ethnicity |journal=Trends Endocrinol. Metab. |volume=15 |issue=10 |pages=472–8 |year=2004 |pmid=15541646 |doi=10.1016/j.tem.2004.10.008 |url=}}</ref> | *Different races have different [[puberty]] onset ages; African-American girls [[menarche]] age (12.2 yrs) are earlier than White girls' (12.9 yrs), which is because of [[Body mass index|body mass index (BMI)]] difference between races.<ref name="pmid15541646">{{cite journal |vauthors=Styne DM |title=Puberty, obesity and ethnicity |journal=Trends Endocrinol. Metab. |volume=15 |issue=10 |pages=472–8 |year=2004 |pmid=15541646 |doi=10.1016/j.tem.2004.10.008 |url=}}</ref> | ||
*Definite diagnosis upon the mean age of [[puberty]] onset in any specific societies can help to reduce the effects of [[ethnicity]] on delayed [[puberty]] [[epidemiology]]. | *Definite diagnosis upon the mean age of [[puberty]] onset in any specific societies can help to reduce the effects of [[ethnicity]] on delayed [[puberty]] [[epidemiology]]. | ||
*50-75% of patients with [[constitutional delay of puberty]] have family history of delayed [[puberty]].<ref name="PalmertDunkel2012" /> | *50-75% of patients with [[constitutional delay of puberty]] have family history of delayed [[puberty]].<ref name="PalmertDunkel2012" /> | ||
===Gender=== | ===Gender=== | ||
*Boys are more commonly affected by delayed [[puberty]] ([[constitutional delay of puberty]]) than girls.<ref name="urlwww.bsped.org.uk">{{cite web |url=http://www.bsped.org.uk/patients/docs/delayed_puberty_tr_version.pdf |title=www.bsped.org.uk |format= |work= |accessdate=}}</ref> | *Boys are more commonly affected by delayed [[puberty]] ([[constitutional delay of puberty]]) than girls.<ref name="urlwww.bsped.org.uk">{{cite web |url=http://www.bsped.org.uk/patients/docs/delayed_puberty_tr_version.pdf |title=www.bsped.org.uk |format= |work= |accessdate=}}</ref> | ||
*The boy to girl ratio is approximately 2 to 1 in [[constitutional delay of puberty]]. | |||
===Developed and Developing Countries=== | ===Developed and Developing Countries=== | ||
* Although there is difference between the age of [[puberty]] onset in [[Developed country|developed]] and developing countries, but delayed [[puberty]] [[epidemiology]] is the same between them. | * Although there is difference between the age of [[puberty]] onset in [[Developed country|developed]] and developing countries, but delayed [[puberty]] [[epidemiology]] is the same between them. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]
Overview
The incidence of delayed puberty (hypogonadotropic hypogonadism) is approximately 1-10 cases per 100,000 individuals worldwide.The precise prevalence of delayed puberty is not known completely. The whole puberty disorders prevalence is about 3000 cases per 100,000 individuals worldwide. Regarding the definition of delayed puberty, the disease commonly affects children under 15 years of age. Delayed puberty usually affects individuals of all races, equally. Definite diagnosis upon the mean age of puberty onset in any specific societies can help to reduce the effects of ethnicity on delayed puberty epidemiology. Boys are more commonly affected by delayed puberty (constitutional delay of puberty) than girls.
Epidemiology and Demographics
Incidence
- The incidence of delayed puberty (hypogonadotropic hypogonadism) is approximately 1-10 cases per 100,000 individuals worldwide.
- Idiopathic hypogonadotropic hypogonadism is responsible for 10% of boys delayed puberty.
- 5-10% of delayed puberty in boys is due to Klinefelter's syndrome (hypergonadotropic hypogonadism).[1]
Prevalence
- The precise prevalence of delayed puberty is not known completely.
- The whole puberty disorders prevalence is about 3000 cases per 100,000 individuals worldwide.[2]
- The prevalence of primary amenorrhea in the US is < 0.1%.[3]
Case-fatality rate
- The case-fatality rate of delayed puberty is approximately zero. There is no reported case of mortality due to delayed puberty.
Age
- Regarding the definition of delayed puberty, the disease commonly affects children under 15 years of age.
Race
- Delayed puberty usually affects individuals of all races, equally.
- Different races have different puberty onset ages; African-American girls menarche age (12.2 yrs) are earlier than White girls' (12.9 yrs), which is because of body mass index (BMI) difference between races.[4]
- Definite diagnosis upon the mean age of puberty onset in any specific societies can help to reduce the effects of ethnicity on delayed puberty epidemiology.
- 50-75% of patients with constitutional delay of puberty have family history of delayed puberty.[1]
Gender
- Boys are more commonly affected by delayed puberty (constitutional delay of puberty) than girls.[5]
- The boy to girl ratio is approximately 2 to 1 in constitutional delay of puberty.
Developed and Developing Countries
- Although there is difference between the age of puberty onset in developed and developing countries, but delayed puberty epidemiology is the same between them.
References
- ↑ 1.0 1.1 Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.
- ↑ Brämswig J, Dübbers A (2009). "Disorders of pubertal development". Dtsch Arztebl Int. 106 (17): 295–303, quiz 304. doi:10.3238/arztebl.2009.0295. PMC 2689583. PMID 19547638.
- ↑ Timmreck LS, Reindollar RH (2003). "Contemporary issues in primary amenorrhea". Obstet. Gynecol. Clin. North Am. 30 (2): 287–302. PMID 12836721.
- ↑ Styne DM (2004). "Puberty, obesity and ethnicity". Trends Endocrinol. Metab. 15 (10): 472–8. doi:10.1016/j.tem.2004.10.008. PMID 15541646.
- ↑ "www.bsped.org.uk" (PDF).