Cretinism natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
*Common complications of | *Common complications of cretinism include:<ref name="pmid27534632">{{cite journal| author=Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB| title=Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns. | journal=Am J Clin Nutr | year= 2016 | volume= 104 Suppl 3 | issue= | pages= 918S-23S | pmid=27534632 | doi=10.3945/ajcn.115.110429 | pmc=5004501 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27534632 }}</ref> | ||
**[ | ** [[Mental retardation]] | ||
**[ | ** [[Growth retardation]] | ||
** | ** Heart problems | ||
===Prognosis=== | ===Prognosis=== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of cretinism usually develop in the first months after birth, and start with symptoms such as jaundice, large fontanelles, and umbilical hernia.
- If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations like ataxia and poor motor coordination.[1]
Complications
- Common complications of cretinism include:[2]
- Mental retardation
- Growth retardation
- Heart problems
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Büyükgebiz A (2003). "Congenital hypothyroidism clinical aspects and late consequences". Pediatr Endocrinol Rev. 1 Suppl 2: 185–90, discussion 190. PMID 16444157.
- ↑ Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB (2016). "Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns". Am J Clin Nutr. 104 Suppl 3: 918S–23S. doi:10.3945/ajcn.115.110429. PMC 5004501. PMID 27534632.