Cretinism natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
If left untreated, | If left untreated, patients with cretinism may progress to develop [[mental retardation]] and [[neurological]] manifestations. Common complications of cretinism include [[growth retardation]] and [[cardiovascular]] problems. Prognosis is usually good with treatment with [[levothyroxine]]. | ||
Common complications of [ | |||
Prognosis is | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*The symptoms of cretinism usually develop in the first months after birth | *The symptoms of cretinism usually develop in the first months after birth and start with symptoms such as jaundice, large fontanelles, and umbilical hernia. | ||
*If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations like ataxia and poor motor coordination.<ref name="pmid16444157">{{cite journal| author=Büyükgebiz A| title=Congenital hypothyroidism clinical aspects and late consequences. | journal=Pediatr Endocrinol Rev | year= 2003 | volume= 1 Suppl 2 | issue= | pages= 185-90; discussion 190 | pmid=16444157 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16444157 }}</ref> | *If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations like ataxia and poor motor coordination.<ref name="pmid16444157">{{cite journal| author=Büyükgebiz A| title=Congenital hypothyroidism clinical aspects and late consequences. | journal=Pediatr Endocrinol Rev | year= 2003 | volume= 1 Suppl 2 | issue= | pages= 185-90; discussion 190 | pmid=16444157 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16444157 }}</ref> | ||
| Line 23: | Line 15: | ||
** [[Mental retardation]] | ** [[Mental retardation]] | ||
** [[Growth retardation]] | ** [[Growth retardation]] | ||
** | ** Cardiovascular problems | ||
===Prognosis=== | ===Prognosis=== | ||
Revision as of 15:32, 8 September 2017
|
Cretinism Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Cretinism natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Cretinism natural history, complications and prognosis |
|
FDA on Cretinism natural history, complications and prognosis |
|
CDC on Cretinism natural history, complications and prognosis |
|
Cretinism natural history, complications and prognosis in the news |
|
Blogs on Cretinism natural history, complications and prognosis |
|
Risk calculators and risk factors for Cretinism natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations. Common complications of cretinism include growth retardation and cardiovascular problems. Prognosis is usually good with treatment with levothyroxine.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of cretinism usually develop in the first months after birth and start with symptoms such as jaundice, large fontanelles, and umbilical hernia.
- If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations like ataxia and poor motor coordination.[1]
Complications
- Common complications of cretinism include:[2]
- Mental retardation
- Growth retardation
- Cardiovascular problems
Prognosis
- Prognosis is generally excellent with the appropriate treatment with levothyroxine.[3]
References
- ↑ Büyükgebiz A (2003). "Congenital hypothyroidism clinical aspects and late consequences". Pediatr Endocrinol Rev. 1 Suppl 2: 185–90, discussion 190. PMID 16444157.
- ↑ Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB (2016). "Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns". Am J Clin Nutr. 104 Suppl 3: 918S–23S. doi:10.3945/ajcn.115.110429. PMC 5004501. PMID 27534632.
- ↑ Rastogi MV, LaFranchi SH (2010). "Congenital hypothyroidism". Orphanet J Rare Dis. 5: 17. doi:10.1186/1750-1172-5-17. PMC 2903524. PMID 20537182.