Pseudohypoparathyroidism history and symptoms: Difference between revisions
Irfan Dotani (talk | contribs) No edit summary |
Mazia Fatima (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Pseudohypoparathyroidism}} | {{Pseudohypoparathyroidism}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{Mazia}} | ||
==Overview== | |||
The diagnosis of pseudohypoparathyroidism Type 1a patients includes clinical features of [[Albright's hereditary osteodystrophy]],[[parathyroid]] hormone resistance evidenced by[[hypocalcemia]],[[hyperphosphatemia]],elevated serum concentration of [[parathyroid]] hormone,diminished urinary [[cAMP]] response after administration of the biosynthetic N-terminal fragment of [[parathyroid]] hormone. | |||
===Diagnostic Criteria=== | |||
The diagnosis of pseudohypoparathyroidism Type 1a patients includes: | |||
*Clinical features of [[Albright's hereditary osteodystrophy]] | |||
*[[Parathyroid]] hormone resistance evidenced by | |||
**[[Hypocalcemia]] | |||
**[[Hyperphosphatemia]] | |||
**Elevated serum concentration of [[parathyroid]] hormone | |||
**Diminished urinary [[cAMP]] response after administration of the biosynthetic N-terminal fragment of [[parathyroid]] hormone. | |||
== | ===History and Symptoms=== | ||
*A positive family history of pseudohypoparathyroidism is suggestive of the [[autosomal dominant]] inheritance. | |||
*The most common symptoms of pseudohypoparathyroidism type 1a include [[short stature]],[[mental retardation]] associated with [[Albright's hereditary osteodystrophy|Albright hereditary Osteodystrophy]] [[phenotype]]. | |||
*Common symptoms due to associated [[hypocalcemia]] include | |||
**[[Paresthesia|Paresthesias]] (peri-oral, extremities) | |||
**[[Muscle twitching]] | |||
**[[Carpopedal spasm]] | |||
**[[Seizures]] | |||
**[[Prolonged QT interval]] | |||
**[[Hypotension]] | |||
**[[Arrhythmia]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:43, 28 September 2017
|
Pseudohypoparathyroidism Microchapters |
|
Differentiating Pseudohypoparathyroidism from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Pseudohypoparathyroidism history and symptoms On the Web |
|
American Roentgen Ray Society Images of Pseudohypoparathyroidism history and symptoms |
|
Risk calculators and risk factors for Pseudohypoparathyroidism history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
The diagnosis of pseudohypoparathyroidism Type 1a patients includes clinical features of Albright's hereditary osteodystrophy,parathyroid hormone resistance evidenced byhypocalcemia,hyperphosphatemia,elevated serum concentration of parathyroid hormone,diminished urinary cAMP response after administration of the biosynthetic N-terminal fragment of parathyroid hormone.
Diagnostic Criteria
The diagnosis of pseudohypoparathyroidism Type 1a patients includes:
- Clinical features of Albright's hereditary osteodystrophy
- Parathyroid hormone resistance evidenced by
- Hypocalcemia
- Hyperphosphatemia
- Elevated serum concentration of parathyroid hormone
- Diminished urinary cAMP response after administration of the biosynthetic N-terminal fragment of parathyroid hormone.
History and Symptoms
- A positive family history of pseudohypoparathyroidism is suggestive of the autosomal dominant inheritance.
- The most common symptoms of pseudohypoparathyroidism type 1a include short stature,mental retardation associated with Albright hereditary Osteodystrophy phenotype.
- Common symptoms due to associated hypocalcemia include
- Paresthesias (peri-oral, extremities)
- Muscle twitching
- Carpopedal spasm
- Seizures
- Prolonged QT interval
- Hypotension
- Arrhythmia