Primary biliary cirrhosis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no established system for the classification of Primary biliary cirrhosis. However, it can be classified into four stages depending on the histology of the disease.

Classification

• There is no established system for the classification of primary biliary cirrhosis. However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification:

Stage 1

Stage 1 is characterized by portal inflammation.

Stage 2

Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss.

Stage 3

There is presence of fibrous septa linking adjacent portal tracts.

Stage 4

Stage 4 is characterized by cirrhosis.