Irritable bowel syndrome causes: Difference between revisions
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==Overview== | ==Overview== | ||
The most common cause of IBS is emotional disturbances, stress, adverse early life events, history of Inflammatory bowel disease, acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes. | The most common cause of IBS is emotional disturbances, stress, adverse early life events, history of [[Inflammatory bowel disease]], acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes. | ||
==Causes== | ==Causes== | ||
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* Emotional disturbance or stress | * Emotional disturbance or stress | ||
* Adverse early life events | * Adverse early life events | ||
* Anxiety, depression | * Anxiety, [[depression]] | ||
* History of acute GI infections e.g. Salmonella infection, Giardiasis | * History of acute GI infections e.g. Salmonella infection, [[Giardiasis]] | ||
* Antibiotic use causing alteration of gut microflora | * Antibiotic use causing alteration of gut microflora | ||
* History of gastrointestinal disorders like IBD | * History of gastrointestinal disorders like [[Inflammatory bowel disease|IBD]] | ||
* Immune causes: history of [[Inflammatory bowel disease|IBD]], [[Celiac disease]], [[microscopic colitis]] | * Immune causes: history of [[Inflammatory bowel disease|IBD]], [[Celiac disease]], [[microscopic colitis]] | ||
Revision as of 20:44, 25 October 2017
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Irritable bowel syndrome Microchapters |
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Differentiating Irritable bowel syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The most common cause of IBS is emotional disturbances, stress, adverse early life events, history of Inflammatory bowel disease, acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes.
Causes
Common Causes
IBS may be caused by:
- Emotional disturbance or stress
- Adverse early life events
- Anxiety, depression
- History of acute GI infections e.g. Salmonella infection, Giardiasis
- Antibiotic use causing alteration of gut microflora
- History of gastrointestinal disorders like IBD
- Immune causes: history of IBD, Celiac disease, microscopic colitis
Less Common Causes
Less common causes of disease name include:
- Genetics
- Hormonal changes
Genetic Causes
- IBS is caused by a mutation of type V (alpha subunit) of SCN5A-encoded voltage gated sodium channel gene. Other genes such as tumour necrosis factor alpha (TNFα) and genes coding for superfamily member 15 (TNFSF15) are also involved.
- SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation and epithelial barriers.
- Genes involved in the regulation of hepatic bile acid synthesis such as a functional Klothoβ gene variant are mutated in IBS patients.
- Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to neuropeptide hormone function and oxidative stress.