Irritable bowel syndrome pathophysiology: Difference between revisions
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**[[Single nucleotide polymorphism|SNPs]] in [[Tumour necrosis factor|tumour necrosis factor alpha]] ([[Tumor necrosis factor-alpha|TNFα)]] and genes coding for superfamily member 15 (''TNFSF15'') have proven associations with [[Irritable bowel syndrome|IBS]].<ref name="pmid12477767" /><ref name="pmid22684480">{{cite journal |vauthors=Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG, Neal KR, Whorwell PJ, Hall IP, Spiller RC |title=Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα |journal=Gut |volume=62 |issue=7 |pages=985–94 |year=2013 |pmid=22684480 |doi=10.1136/gutjnl-2011-301213 |url=}}</ref><ref name="pmid21636646">{{cite journal |vauthors=Zucchelli M, Camilleri M, Andreasson AN, Bresso F, Dlugosz A, Halfvarson J, Törkvist L, Schmidt PT, Karling P, Ohlsson B, Duerr RH, Simren M, Lindberg G, Agreus L, Carlson P, Zinsmeister AR, D'Amato M |title=Association of TNFSF15 polymorphism with irritable bowel syndrome |journal=Gut |volume=60 |issue=12 |pages=1671–1677 |year=2011 |pmid=21636646 |pmc=3922294 |doi=10.1136/gut.2011.241877 |url=}}</ref> | **[[Single nucleotide polymorphism|SNPs]] in [[Tumour necrosis factor|tumour necrosis factor alpha]] ([[Tumor necrosis factor-alpha|TNFα)]] and genes coding for superfamily member 15 (''TNFSF15'') have proven associations with [[Irritable bowel syndrome|IBS]].<ref name="pmid12477767" /><ref name="pmid22684480">{{cite journal |vauthors=Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG, Neal KR, Whorwell PJ, Hall IP, Spiller RC |title=Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα |journal=Gut |volume=62 |issue=7 |pages=985–94 |year=2013 |pmid=22684480 |doi=10.1136/gutjnl-2011-301213 |url=}}</ref><ref name="pmid21636646">{{cite journal |vauthors=Zucchelli M, Camilleri M, Andreasson AN, Bresso F, Dlugosz A, Halfvarson J, Törkvist L, Schmidt PT, Karling P, Ohlsson B, Duerr RH, Simren M, Lindberg G, Agreus L, Carlson P, Zinsmeister AR, D'Amato M |title=Association of TNFSF15 polymorphism with irritable bowel syndrome |journal=Gut |volume=60 |issue=12 |pages=1671–1677 |year=2011 |pmid=21636646 |pmc=3922294 |doi=10.1136/gut.2011.241877 |url=}}</ref> | ||
**[[Tumor necrosis factors|TNF]] [[polymorphisms]] are also associated with post [[Infection|infectious]] [[Irritable bowel syndrome|IBS]] such as ''rs4263839'' in ''TNFSF15'' and [[Irritable bowel syndrome|IBS]], particularly IBS associated with [[constipation]].<ref name="pmid21636646" /><ref name="pmid22684480" /> | **[[Tumor necrosis factors|TNF]] [[polymorphisms]] are also associated with post [[Infection|infectious]] [[Irritable bowel syndrome|IBS]] such as ''rs4263839'' in ''TNFSF15'' and [[Irritable bowel syndrome|IBS]], particularly IBS associated with [[constipation]].<ref name="pmid21636646" /><ref name="pmid22684480" /> | ||
==Medical conditions that accompany IBS== | |||
Several medical [[comorbidities]] appear with greater frequency in [[Irritable bowel syndrome|IBS]] patients. | |||
===Headache, Fibromyalgia, and Depression=== | |||
[[Irritable bowel syndrome|IBS]] patients may be identified with comorbidities such as [[headache]], [[fibromyalgia]] and [[depression]].<ref>{{cite journal |author=Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA |title=Migraine,[[fibromyalgia]], and depression among people with IBS: a prevalence study |journal=BMC gastroenterology |volume=6 |issue=|pages=26 |year=2006 |pmid=17007634 |doi=10.1186/1471-230X-6-26}}</ref><ref name="pmid16614951">{{cite journal |author=Kurland JE, Coyle WJ, Winkler A, Zable E |title=Prevalence of irritable bowel syndrome and depression in [[fibromyalgia]] |journal=Dig. Dis. Sci. |volume=51 |issue=3 |pages=454-60 |year=2006|pmid=16614951 |doi=10.1007/s10620-006-3154-7}}</ref><ref name="pmid16042909">{{cite journal |author=Frissora CL, Koch KL|title=Symptom overlap and comorbidity of irritable bowel syndrome with other conditions |journal=Current gastroenterology reports|volume=7 |issue=4 |pages=264-71 |year=2005 |pmid=16042909 |doi=}}</ref> | |||
===Inflammatory Bowel Disease=== | |||
* [[Irritable bowel syndrome|IBS]] and [[Inflammatory bowel disease|IBD]] are interrelated diseases, as patients with [[Inflammatory bowel disease|IBD]] experience [[Irritable bowel syndrome|IBS]]-like symptoms when their [[Inflammatory bowel disease|IBD]] is in remission.<ref name="SIMREN_2002">{{cite journal |author=Simrén M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J, Björnsson ES|title=Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors |journal=Am. J. Gastroenterol. |volume=97 |issue=2 |pages=389-96 |year=2002 |pmid=11866278 |doi=}}</ref><ref name="MINDERHOUD_2004">{{cite journal |author=Minderhoud IM, Oldenburg B, Wismeijer JA, van Berge Henegouwen GP, Smout AJ|title=IBS-like symptoms in patients with inflammatory bowel disease in remission; relationships with quality of life and coping behavior |journal=Dig. Dis. Sci. |volume=49 |issue=3 |pages=469-74 |year=2004 |pmid=15139501 |doi=}}</ref><ref name="QUIGLEY_2005">{{cite journal |author=Quigley EM |title=Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases? |journal=Chinese journal of digestive diseases |volume=6 |issue=3 |pages=122-32 |year=2005 |pmid=16045602|doi=10.1111/j.1443-9573.2005.00202.x}}</ref> | |||
* [[Irritable bowel syndrome|IBS]] is believed to be a type of low-grade [[inflammatory bowel disease]] as serum markers associated with [[inflammation]] have also been found in patients with [[Irritable bowel syndrome|IBS]] .<ref name="BERCIK_2005">{{cite journal |author=Bercik P, Verdu EF, Collins SM |title=Is irritable bowel syndrome a low-grade inflammatory bowel disease? |journal=Gastroenterol. Clin. North Am. |volume=34 |issue=2 |pages=235-45, vi-vii |year=2005|pmid=15862932 |doi=10.1016/j.gtc.2005.02.007}}</ref> | |||
* [[Irritable bowel syndrome|IBS]] patients are16.3 times more likely to develop [[Inflammatory bowel disease|IBD]].<ref name="GARCIA_2000">{{cite journal |author=García Rodríguez LA, Ruigómez A, Wallander MA, Johansson S, Olbe L |title=Detection of colorectal tumor and inflammatory bowel disease during follow-up of patients with initial diagnosis of irritable bowel syndrome |journal=Scand. J. Gastroenterol. |volume=35 |issue=3 |pages=306-11 |year=2000 |pmid=10766326 |doi=}}</ref> | |||
===Abdominal Surgery=== | |||
* [[Irritable bowel syndrome|IBS]] patients are 87% more likely to undergo [[Abdomen|abdominal]] and [[Pelvis|pelvic]] [[surgery]], and three times more likely to undergo [[gallbladder]] [[surgery]].<ref name="pmid16416174">{{cite journal |author=Cole JA, Yeaw JM, Cutone JA, ''et al'' |title=The incidence of abdominal and pelvic surgery among patients with irritable bowel syndrome |journal=Dig. Dis. Sci. |volume=50 |issue=12 |pages=2268–75 |year=2005 |pmid=16416174|doi=10.1007/s10620-005-3047-1}}</ref> | |||
* [[Irritable bowel syndrome|IBS]] patients were twice as likely to undergo [[hysterectomy]].<ref name="pmid15188159">{{cite journal |author=Longstreth GF, Yao JF|title=Irritable bowel syndrome and surgery: a multivariable analysis |journal=Gastroenterology |volume=126 |issue=7 |pages=1665–73|year=2004 |pmid=15188159 |doi=}}</ref> | |||
===Endometriosis=== | |||
There is a statistically significant link between [[Migraine|migraine headaches]], [[Irritable bowel syndrome|IBS]], and [[endometriosis]].<ref name="pmid17635599">{{cite journal |author=Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F|title=Endometriosis is associated with prevalence of comorbid conditions in migraine |journal=Headache |volume=47 |issue=7|pages=1069-78 |year=2007 |pmid=17635599 |doi=10.1111/j.1526-4610.2007.00784.x}}</ref> | |||
==Medical conditions that accompany IBS== | ==Medical conditions that accompany IBS== | ||
Revision as of 19:14, 6 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
IBS is caused by the complex interaction of various factors such as intrinsic gastrointestinal factors, CNS dysregulation and psychosocial factors, genetic and environmental factors. Intrinsic gastrointestinal factors include motor abnormalities, visceral hypersensitivity, immune activation and mucosal inflammation, altered gut microbiota and abnormal serotonin pathways. Visceral hypersensitivity is a decreased threshold for the perception of visceral stimuli that affects spinal excitability brain stem and cortical modulation, activation of specific gastrointestinal mediators and recruitment of peripheral silent nociceptors. Immune activation and mucosal inflammation involves an interaction of lymphocytes, mast cells and proinflammatory cytokines. Environmental factors encompass dietary changes and infections. Psychosocial factors such as stress, anxiety and depression directly shape adult connectivity in the executive control network consisting of structures such as the insula, anterior cingulate cortex and the thalamus. Semipermanent/permanent changes in complex neural circuits lead to central pain amplification and contribute to abdominal pain in IBS patients. The dorsolateral prefrontal cortex activity (responsible for vigilance and alertness of the human brain) and the mid-cingulate cortex (engaged in attention pathways and responses) is reduced in IBS patients, which may lead to alterations in the subjective sensations of pain. Genetic factors also play a role in IBS. It has high twin concordance and familial aggregation. It is associated with Single nucleotide polymorphisms (SNPs) in genes involved in immune activation, neuropeptide hormone function, oxidative stress, nociception, permeability of the GI tract, host-microbiota interaction, inflammation, and TNF activity.
Pathophysiology
Pathogenesis
IBS is an interplay between four main factors:
| CNS dysregulation and psychosocial factors | |||||||||||||||||||||||||||||
| Intrinsic gastrointestinal factors: • Motor abnormalities • Visceral hypersensitivity • Immune activation and mucosal inflammation • Altered gut microbiota • Abnormal serotonin pathways | IRRITABLE BOWEL SYNDROME | Genetic factors: • Twin concordance • Familial aggregation • Single Nucleotide Polymorphisms(SNPs) • TNF polymorphism | |||||||||||||||||||||||||||
| Environmental factors | |||||||||||||||||||||||||||||
Environmental factors
- Diet
- Fermentable oligosaccharides, monosaccharides, disaccharides, and polyols (FODMAPs) are present in stone fruits, artificial sweeteners, lactose-containing foods, and legumes. Changes in diet such as increased amounts (FODMAPs) can alter gut microflora.[1]
- Fermentation and osmotic effects of FODMAPs produce abdominal discomfort and diarrhea in IBS.
- FODMAPs yield carbon dioxide, methane, and hydrogen that are responsible for bloating.
- Osmotically active carbohydrate by products lead to diarrhea by enhancing intestinal contractions and precipitating fluid secretion.[2][3][4][5][6][7][8][9]
- Infection
- Infectious gastroenteritis triggers micro inflammation, and up to one third of irritable bowel syndrome cases follow acute gastroenteritis.
- Micro inflammation of the gut causes activation of the lymphocytes, mast cells and pro inflammatory cytokines that stimulate the enteric nervous system and lead to abnormal visceral and motor responses within the gastrointestinal tract.
- Immune activation due to GI infection also increases enteroendocrine cells, calprotectin-positive macrophages, intraepithelial lymphocytes, and lamina propria T cells which contribute directly to abdominal pain perception. [10][11][12][13][14][15][16][17][18]
Intrinsic gastrointestinal factors
- Motor abnormalities:
- IBS is referred to as ‘spastic colon’ due to changes in colonic motor function.
- Manometry recordings from the transverse, descending and sigmoid colon have shown that IBS leads to changed patterns of colonic and small intestinal motor function, such as increased frequency and irregularity of luminal contractions.
- Motor changes lead to symptoms of diarrhea and constipation.[19][20][21]
- Diarrhea-prone IBS patients have increased responses to ingestion, CRH (corticotropin releasing hormone), CCK (cholecystokinin), which increase the peak amplitude of high-amplitude propagating contractions (HAPCs) and lead to abdominal discomfort with accelerated transit through the colon. [22][23][24][25][26]
- Constipation-prone IBS patients show fewer high-amplitude propagating contractions (HAPCs) as compared to diarrhea prone IBS patients, delayed transit through the colon and decreased motility.
- Changes in the motor function of the colon are responsible for producing the gastrointestinal symptoms of IBS such as altered bowel habits and abdominal pain.[25]
- Visceral hypersensitivity:
- IBS is associated with a decreased threshold for perception of visceral stimuli (i.e. visceral hypersensitivity)[25][27][28]
- Rectal distension produces painful and non-painful sensations at lower volumes in IBS patients as compared to healthy controls, suggesting the presence of afferent pathway disturbances in visceral innervation[29][30][31][32].
- Visceral hypersensitivity contributes to IBS by involving the following:
- Spinal hyperexcitability
- Secondary to activation of neurotransmitters such as:
- N-methyl D aspartate (NMDA) receptor
- nitric oxide
- Activation of specific gastrointestinal mediators that lead to afferent nerve fiber sensitization:
- Central (brainstem and cortical) modulation with increased activation of anterior cingulate cortex, thalamus and insula.
- These structures are involved in processing of pain.
- Cortical and brain stem modulation translate into long term hypersensitivity due to neuroplasticity.
- Semi permanent changes(seen on functional magnetic resonance imaging and positron emission tomography) in the neural response to visceral stimulation contribute to visceral hypersensitivity.[27][33]
- Recruitment of peripheral silent nociceptors cause increased end organ sensitivity due to
- hormonal activation ( increased serotonin affects gastrointestinal motility and visceral pain perception)
- immune activation(recruitment of inflammatory mediators)[27]
- Spinal hyperexcitability
| Spinal hyperexcitability | Activation of • N-methyl D aspartate (NMDA) receptor • nitric oxide | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Central (brainstem and cortical) modulation | Increased activation of: • Anterior cingulate cortex • Thalamus • insula | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Visceral hypersensitivity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Activation of specific gastrointestinal mediators | Kinins and serotonin activation lead to afferent nerve fiber sensitization | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Recruitment of peripheral silent nociceptors | Increased end organ sensitivity due to hormonal or immune activation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
- Immune activation and mucosal inflammation
Mast cells IMMUNE ACTIVATION AND MUCOSAL INFLAMMATION Lymphocytes Proinflammatory cytokines - IBS in patients with history of inflammatory bowel disease, celiac disease or microscopic colitis points towards the fact that immune activation and local GI mucosal inflammation play an important role in its pathogenesis.[34][35][36][37][38][39][36]
- IBS patients have higher mucosal counts of lymphocytes (T cells, B cells), mast cells and immune mediators such as prostanoids, proteases, cytokines and histamines.[36][40][41][42][43]
- Lymphocytes:
- Activation of humoral immunity in IBS is specific for the gastrointestinal tract. Increased number of lymphocytes have been found in the small intestine and colon of IBS patients.[35][37][44][45]
- IBS patients with diarrhea have enhanced mucosal humoral activity, associated with activation and proliferation of B cells and immunoglobulin production, identified by microarray profiling.[45]
- IBS patients with severe disease have an increase in lymphocyte infiltration in the myentric plexus.[37]
- Mediators released by lymphocytes include histamine, proteases and nitric oxide. The stimulation of the enteric nervous system by these mediators leads to abnormal visceral and motor responses within the gastrointestinal tract.[35]
- Stool in patients with diarrhea prominent IBS demonstrates high levels of serine protease activity, which is produced by lymphocytes.[46][47]
- In response to high levels of serine protease, there is increased visceral pain and colonic cellular permeability. [46]
- Serine protease inhibitors prevent effects mediated by high levels of serine protease in IBS patients.[47][46]
- Mast cells:
- IBS leads to an increased number of mast cells in IBS patients in the jejunum, terminal ileum and colon.[39]
- Higher numbers of activated mast cells are found in proximity to colonic nerve fibres in the mucosa of the gastrointestinal tract of IBS patients. [39][38]
- Proinflammatory cytokines:
- Cytokines are protein mediators of the immune response. Increased levels of cytokines have been found in IBS patients.[43][42]
- Higher amounts of tumor necrosis factor are produced by the peripheral blood mononuclear cells of IBS patients.[48][36]
- Other cytokines such as interleukin 1β, interleukin 6, interleukin10, and TNFα are raised in IBS patients.
- Increased concentration of cytokines is directly proportional to the severity and frequency of pain.[36][49][48]
- The TNF antagonist infliximab counteracts pain in IBS patients, proving TNF involvement in mechanical hypersensitivity of the colonic afferent nerve endings . [49]
- Altered gut microbiota
- Fecal microflora in IBS patients differ from healthy individuals. Some IBS patients have colonic spirochaetosis, with a unique pathology of increased lymphoid follicles and eosinophils on histology.[40][50] [51][52][53][54][14][55]
- Acute GI infection alters gut microflora switches on a T-helper-2 immune-cell response with increased numbers of CD8 and CD4RA-positive intraepithelial lymphocytes, causing increased susceptibility to the development of IBS. [56][57][58]
- Altered gut microbiota causes increased colonic hypersensitivity. [59]
- Abnormal serotonin pathways
- Serotonin(5-HT) is an important neurotransmitter produced by the enterochromaffin cells in the colon, in response to chemical stimuli (short chain fatty acids produced by gastrointestinal microflora ) and mechanical stimuli ( food) and is increased in IBS patients.[60][61][62][63][64][65][66]
- Serotonin affects gastrointestinal motility and visceral pain perception. Spontaneous release of 5-HT correlates with abdominal pain severity.[67]
- There is an established relationship between IBS and polymorphisms in the gene for serotonin transport causing alteration in intestinal peristalsis due to change in the serotonin reuptake efficacy.[68][69][70][71]
- Increased serotonin production contributes to postprandial symptoms in IBS patients, hence providing the rationale for the therapeutic efficacy of 5-HT 3 receptor antagonists and 5-HT 4 receptor agonists on symptoms in IBS patients.[72][73]
Psychosocial factors and CNS dysregulation
- Symptom exacerbation occurs in IBS patients with emotional disturbances,stress, anxiety or depression. Traumatic experiences before 18 years of age directly shape adult connectivity in the executive control network consisting of structures such as the insula, anterior cingulate cortex and the thalamus.
- Semipermanent/permanent changes in complex neural circuits lead to central pain amplification and contribute to abdominal pain in IBS patients.[74][75]
- The dorsolateral prefrontal cortex activity (responsible for vigilance and alertness of the human brain) and the mid-cingulate cortex (engaged in attention pathways and responses) is reduced in IBS patients, seen on advanced brain imaging techniques as irregularities in the mid- cingulate cortex and prefrontal cortex on diffusion tensor imaging. [76]
- prefrontal cortex modulation may lead to increased perception of visceral pain.
- Modulation of the mid-cingulate cortex is associated with alterations in the subjective sensations of pain.[77][78]
- Patients with IBS have aberrant processing of central information, with decreased feedback on the emotional arousal network that controls the autonomic activity of the gastrointestinal tract and changes gut motility.[79][80]
- IBS is a brain gut disorder as rectal distension in patients causes increased engagement of regions of the brain associated with attentional and behavioral responses.[77][81][82]
- Psychological stress also impacts the release of gut proinflammatory cytokines, contributing to pain in IBS patients.[34]
Genetic factors
- IBS has high twin concordance and familial aggregation:[83][84][85][86][87][88]
- IBS has higher concordance in monozygotic as compared to dizygotic twins.[83][84][85][89]
- Individuals with a biologic relative with IBS have two times a higher risk of developing IBS. [90]
- Single nucleotide polymorphisms (SNPs) in genes:
- IBS has SNPs in genes playing an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation and epithelial barriers.
- SNPs cause inflammation and increased permeability of the GI tract, leading to abdominal discomfort and increased motility.[91][92]
- Mutation of type V (alpha subunit) of SCN5A-encoded voltage gated sodium channel causes IBS.[93][94]
- Genome wide DNA methylation profiling is impaired in IBS and this involves genes linked to neuropeptide hormone function and oxidative stress.[95]
- IBS causes mutation in the neuropeptide S receptor gene (NPSR1) involved in nociception, inflammation and anxiety with abdominal pain.[96]
- Genes involved in the regulation of hepatic bile acid synthesis such as a functional Klothoβ gene are mutated in IBS.[97][98]
- TNF polymorphisms:
- SNPs in tumour necrosis factor alpha (TNFα) and genes coding for superfamily member 15 (TNFSF15) have proven associations with IBS.[92][99][100]
- TNF polymorphisms are also associated with post infectious IBS such as rs4263839 in TNFSF15 and IBS, particularly IBS associated with constipation.[100][99]
Medical conditions that accompany IBS
Several medical comorbidities appear with greater frequency in IBS patients.
Headache, Fibromyalgia, and Depression
IBS patients may be identified with comorbidities such as headache, fibromyalgia and depression.[101][102][103]
Inflammatory Bowel Disease
- IBS and IBD are interrelated diseases, as patients with IBD experience IBS-like symptoms when their IBD is in remission.[104][105][106]
- IBS is believed to be a type of low-grade inflammatory bowel disease as serum markers associated with inflammation have also been found in patients with IBS .[107]
- IBS patients are16.3 times more likely to develop IBD.[108]
Abdominal Surgery
- IBS patients are 87% more likely to undergo abdominal and pelvic surgery, and three times more likely to undergo gallbladder surgery.[109]
- IBS patients were twice as likely to undergo hysterectomy.[110]
Endometriosis
There is a statistically significant link between migraine headaches, IBS, and endometriosis.[111]
Medical conditions that accompany IBS
Several medical comorbidities appear with greater frequency in IBS patients.
Headache, Fibromyalgia, and Depression
IBS patients may be identified with comorbidities such as headache, fibromyalgia and depression.[112][102][103]
Inflammatory Bowel Disease
- IBS and IBD are interrelated diseases, as patients with IBD experience IBS-like symptoms when their IBD is in remission.[104][105][106]
- IBS is believed to be a type of low-grade inflammatory bowel disease as serum markers associated with inflammation have also been found in patients with IBS .[107]
- IBS patients are16.3 times more likely to develop IBD.[108]
Abdominal Surgery
- IBS patients are 87% more likely to undergo abdominal and pelvic surgery, and three times more likely to undergo gallbladder surgery.[109]
- IBS patients were twice as likely to undergo hysterectomy.[110]
Endometriosis
There is a statistically significant link between migraine headaches, IBS, and endometriosis.[111]
Gross Pathology
Microscopic Pathology
Microscopic changes that may be found in IBS patients are as follows:[113][17][60][114][115][116][117][118][119][37][120][39]
LOCATION LAYER OF INTESTINE INVOLVED MAST CELLS T LYMPHOCYTES ENTEROCHROMAFFIN CELLS Rectum Mucosa +++/- +/- +/- Terminal ileum Mucosa - ++ - Cecum Mucosa ++ - - Colon Muscularis externa +/- - - Jejunum Myentric plexus ++ - - References
- ↑ Muir JG, Gibson PR (2013). "The Low FODMAP Diet for Treatment of Irritable Bowel Syndrome and Other Gastrointestinal Disorders". Gastroenterol Hepatol (N Y). 9 (7): 450–2. PMC 3736783. PMID 23935555.
- ↑ Böhn L, Störsrud S, Törnblom H, Bengtsson U, Simrén M (2013). "Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life". Am. J. Gastroenterol. 108 (5): 634–41. doi:10.1038/ajg.2013.105. PMID 23644955.
- ↑ Young E, Stoneham MD, Petruckevitch A, Barton J, Rona R (1994). "A population study of food intolerance". Lancet. 343 (8906): 1127–30. PMID 7910231.
- ↑ David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ (2014). "Diet rapidly and reproducibly alters the human gut microbiome". Nature. 505 (7484): 559–63. doi:10.1038/nature12820. PMC 3957428. PMID 24336217.
- ↑ Francis CY, Whorwell PJ (1994). "Bran and irritable bowel syndrome: time for reappraisal". Lancet. 344 (8914): 39–40. PMID 7912305.
- ↑ Elli L, Tomba C, Branchi F, Roncoroni L, Lombardo V, Bardella MT, Ferretti F, Conte D, Valiante F, Fini L, Forti E, Cannizzaro R, Maiero S, Londoni C, Lauri A, Fornaciari G, Lenoci N, Spagnuolo R, Basilisco G, Somalvico F, Borgatta B, Leandro G, Segato S, Barisani D, Morreale G, Buscarini E (2016). "Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten Challenge". Nutrients. 8 (2): 84. doi:10.3390/nu8020084. PMC 4772047. PMID 26867199.
- ↑ Coletta M, Gates FK, Marciani L, Shiwani H, Major G, Hoad CL, Chaddock G, Gowland PA, Spiller RC (2016). "Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans". Br. J. Nutr. 115 (1): 55–61. doi:10.1017/S0007114515004183. PMID 26522233.
- ↑ Yang J, Fox M, Cong Y, Chu H, Zheng X, Long Y, Fried M, Dai N (2014). "Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity". Aliment. Pharmacol. Ther. 39 (3): 302–11. doi:10.1111/apt.12582. PMID 24308871.
- ↑ Staudacher HM, Irving PM, Lomer MC, Whelan K (2014). "Mechanisms and efficacy of dietary FODMAP restriction in IBS". Nat Rev Gastroenterol Hepatol. 11 (4): 256–66. doi:10.1038/nrgastro.2013.259. PMID 24445613.
- ↑ Ohman L, Simrén M (2010). "Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions". Nat Rev Gastroenterol Hepatol. 7 (3): 163–73. doi:10.1038/nrgastro.2010.4. PMID 20101257.
- ↑ Simrén M, Barbara G, Flint HJ, Spiegel BM, Spiller RC, Vanner S, Verdu EF, Whorwell PJ, Zoetendal EG (2013). "Intestinal microbiota in functional bowel disorders: a Rome foundation report". Gut. 62 (1): 159–76. doi:10.1136/gutjnl-2012-302167. PMC 3551212. PMID 22730468.
- ↑ Ohman L, Simrén M (2013). "Intestinal microbiota and its role in irritable bowel syndrome (IBS)". Curr Gastroenterol Rep. 15 (5): 323. doi:10.1007/s11894-013-0323-7. PMID 23580243.
- ↑ Posserud I, Stotzer PO, Björnsson ES, Abrahamsson H, Simrén M (2007). "Small intestinal bacterial overgrowth in patients with irritable bowel syndrome". Gut. 56 (6): 802–8. doi:10.1136/gut.2006.108712. PMC 1954873. PMID 17148502.
- ↑ 14.0 14.1 Jeffery IB, O'Toole PW, Öhman L, Claesson MJ, Deane J, Quigley EM, Simrén M (2012). "An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota". Gut. 61 (7): 997–1006. doi:10.1136/gutjnl-2011-301501. PMID 22180058.
- ↑ Spiller R, Garsed K (2009). "Postinfectious irritable bowel syndrome". Gastroenterology. 136 (6): 1979–88. doi:10.1053/j.gastro.2009.02.074. PMID 19457422.
- ↑ Joo YE (2015). "Alteration of fecal microbiota in patients with postinfectious irritable bowel syndrome". J Neurogastroenterol Motil. 21 (1): 135–7. doi:10.5056/jnm14133. PMC 4288086. PMID 25611066.
- ↑ 17.0 17.1 Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ, Underwood JE, Read NW (1999). "The role of psychological and biological factors in postinfective gut dysfunction". Gut. 44 (3): 400–6. PMC 1727402. PMID 10026328.
- ↑ Nielsen HL, Engberg J, Ejlertsen T, Nielsen H (2014). "Psychometric scores and persistence of irritable bowel after Campylobacter concisus infection". Scand. J. Gastroenterol. 49 (5): 545–51. doi:10.3109/00365521.2014.886718. PMID 24646319.
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