Incidentaloma risk factors: Difference between revisions
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Most [[Adrenocortical carcinoma|adrenocortical carcinomas]] are sporadic, but some occur as a component of hereditary [[cancer]] [[syndromes]].<ref name="pmid14685087">{{cite journal| author=Sidhu S, Sywak M, Robinson B, Delbridge L| title=Adrenocortical cancer: recent clinical and molecular advances. | journal=Curr Opin Oncol | year= 2004 | volume= 16 | issue= 1 | pages= 13-8 | pmid=14685087 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14685087 }}</ref><ref name="pmid2300390">{{cite journal| author=Lynch HT, Radford B, Lynch JF| title=SBLA syndrome revisited. | journal=Oncology | year= 1990 | volume= 47 | issue= 1 | pages= 75-9 | pmid=2300390 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2300390 }}</ref> | Most [[Adrenocortical carcinoma|adrenocortical carcinomas]] are sporadic, but some occur as a component of hereditary [[cancer]] [[syndromes]].<ref name="pmid14685087">{{cite journal| author=Sidhu S, Sywak M, Robinson B, Delbridge L| title=Adrenocortical cancer: recent clinical and molecular advances. | journal=Curr Opin Oncol | year= 2004 | volume= 16 | issue= 1 | pages= 13-8 | pmid=14685087 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14685087 }}</ref><ref name="pmid2300390">{{cite journal| author=Lynch HT, Radford B, Lynch JF| title=SBLA syndrome revisited. | journal=Oncology | year= 1990 | volume= 47 | issue= 1 | pages= 75-9 | pmid=2300390 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2300390 }}</ref> | ||
* [[Heredity|Hereditary]] [[cancer]] [[syndromes]]: | * [[Heredity|Hereditary]] [[cancer]] [[syndromes]]: | ||
** [[Li-Fraumeni syndrome]] (associated with inactivating mutations of the ''[[TP53 (gene)|TP53]]'' [[tumor suppressor gene]] on chromosome 17p): | ** [[Li-Fraumeni syndrome]] (associated with inactivating [[Mutation|mutations]] of the ''[[TP53 (gene)|TP53]]'' [[tumor suppressor gene]] on chromosome 17p): | ||
***[[Breast cancer]] | ***[[Breast cancer]] | ||
*** Soft tissue and [[bone sarcoma]] | *** Soft tissue and [[bone sarcoma]] | ||
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***[[Wilms' tumor]][[Neuroblastoma| Neuroblastoma]] | ***[[Wilms' tumor]][[Neuroblastoma| Neuroblastoma]] | ||
***[[Hepatoblastoma]] | ***[[Hepatoblastoma]] | ||
**[[Multiple endocrine neoplasia type 1]] ([[MEN1]]) (associated with inactivating mutations of the [[MEN1|''MEN1'' gene]] on chromosome 11q): | **[[Multiple endocrine neoplasia type 1]] ([[MEN1]]) (associated with inactivating mutations of the [[MEN1|''MEN1'' gene]] on [[chromosome]] 11q): | ||
***[[Parathyroid adenoma|Parathyroid adenoma]] | ***[[Parathyroid adenoma|Parathyroid adenoma]] | ||
*** [[Pituitary adenoma|Pituitary adenoma]] | *** [[Pituitary adenoma|Pituitary adenoma]] | ||
Latest revision as of 16:43, 7 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Multiple endocrine neoplasia type 1(MEN1).
Risk Factors
Most adrenocortical carcinomas are sporadic, but some occur as a component of hereditary cancer syndromes.[1][2]
- Hereditary cancer syndromes:
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
- Breast cancer
- Soft tissue and bone sarcoma
- Brain tumors
- Beckwith-Wiedemann syndrome (associated with abnormalities in 11p15):
- Multiple endocrine neoplasia type 1 (MEN1) (associated with inactivating mutations of the MEN1 gene on chromosome 11q):
- Li-Fraumeni syndrome (associated with inactivating mutations of the TP53 tumor suppressor gene on chromosome 17p):
References
- ↑ Sidhu S, Sywak M, Robinson B, Delbridge L (2004). "Adrenocortical cancer: recent clinical and molecular advances". Curr Opin Oncol. 16 (1): 13–8. PMID 14685087.
- ↑ Lynch HT, Radford B, Lynch JF (1990). "SBLA syndrome revisited". Oncology. 47 (1): 75–9. PMID 2300390.