Toxic megacolon laboratory findings: Difference between revisions
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*Laboratory findings consistent with the diagnosis of toxic megacolon include:<ref name="pmid24163654">{{cite journal |vauthors=Antonopoulos P, Almyroudi M, Kolonia V, Kouris S, Troumpoukis N, Economou N |title=Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis |journal=Case Rep Gastroenterol |volume=7 |issue=3 |pages=409–13 |year=2013 |pmid=24163654 |pmc=3806696 |doi=10.1159/000355345 |url=}}</ref><ref name="pmid12067">{{cite journal |vauthors=Caprilli R, Vernia P, Colaneri O, Torsoli A |title=Blood pH: a test for assessment of severity in proctocolitis |journal=Gut |volume=17 |issue=10 |pages=763–9 |year=1976 |pmid=12067 |pmc=1411181 |doi= |url=}}</ref> | *Laboratory findings consistent with the diagnosis of toxic megacolon include:<ref name="pmid24163654">{{cite journal |vauthors=Antonopoulos P, Almyroudi M, Kolonia V, Kouris S, Troumpoukis N, Economou N |title=Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis |journal=Case Rep Gastroenterol |volume=7 |issue=3 |pages=409–13 |year=2013 |pmid=24163654 |pmc=3806696 |doi=10.1159/000355345 |url=}}</ref><ref name="pmid12067">{{cite journal |vauthors=Caprilli R, Vernia P, Colaneri O, Torsoli A |title=Blood pH: a test for assessment of severity in proctocolitis |journal=Gut |volume=17 |issue=10 |pages=763–9 |year=1976 |pmid=12067 |pmc=1411181 |doi= |url=}}</ref> | ||
**[[Anemia]] | **[[Anemia]] | ||
**[[Leukocytosis]] | **[[Leukocytosis]] especially in patients with C. difficile infection | ||
**Hypoalbuminemia | **Hypoalbuminemia | ||
**Metabolic alkalosis associated with a poor prognosis | **Metabolic alkalosis associated with a poor prognosis | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of toxic megacolon include anemia and leukocytosis. Some patients with toxic megacolon may have elevated concentration of ESR and CRP, which is usually suggestive of inlammation.[1]
Laboratory Findings
- Laboratory findings consistent with the diagnosis of toxic megacolon include:[2][3]
- Anemia
- Leukocytosis especially in patients with C. difficile infection
- Hypoalbuminemia
- Metabolic alkalosis associated with a poor prognosis
- Metabolic acidosis secondary to ischemic colitis
- Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.[4][5][6][7]
- Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.[8][9][10]
References
- ↑ Autenrieth DM, Baumgart DC (2012). "Toxic megacolon". Inflamm. Bowel Dis. 18 (3): 584–91. doi:10.1002/ibd.21847. PMID 22009735.
- ↑ Antonopoulos P, Almyroudi M, Kolonia V, Kouris S, Troumpoukis N, Economou N (2013). "Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis". Case Rep Gastroenterol. 7 (3): 409–13. doi:10.1159/000355345. PMC 3806696. PMID 24163654.
- ↑ Caprilli R, Vernia P, Colaneri O, Torsoli A (1976). "Blood pH: a test for assessment of severity in proctocolitis". Gut. 17 (10): 763–9. PMC 1411181. PMID 12067.
- ↑ Brown, S. R.; Haboubi, N.; Hampton, J.; George, B.; Travis, S. P. L. (2008). "The Management of Acute Severe Colitis: ACPGBI Position Statement". Colorectal Disease. 10: 8–29. doi:10.1111/j.1463-1318.2008.01682.x. ISSN 1462-8910.
- ↑ Strong SA (2010). "Management of acute colitis and toxic megacolon". Clin Colon Rectal Surg. 23 (4): 274–84. doi:10.1055/s-0030-1268254. PMC 3134807. PMID 22131898.
- ↑ Orabona, Rossana; Valcamonico, Adriana; Salemme, Marianna; Manenti, Stefania; Tiberio, Guido AM; Frusca, Tiziana (2015). "Fulminant ulcerative colitis in a healthy pregnant woman". World Journal of Gastroenterology. 21 (19): 6060–6064. doi:10.3748/wjg.v21.i19.6060. ISSN 1007-9327.
- ↑ Chao HC, Chiu CH, Kong MS, Chang LY, Huang YC, Lin TY, Lou CC (2000). "Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon". Pediatr. Infect. Dis. J. 19 (12): 1158–62. PMID 11144376.
- ↑ Panos MZ, Wood MJ, Asquith P (1993). "Toxic megacolon: the knee-elbow position relieves bowel distension". Gut. 34 (12): 1726–7. PMC 1374472. PMID 8282262.
- ↑ Sheth SG, LaMont JT (1998). "Toxic megacolon". Lancet. 351 (9101): 509–13. doi:10.1016/S0140-6736(97)10475-5. PMID 9482465.
- ↑ {cite book | last = Koyfman | first = Alex | title = Emergency medicine images for practice : an overview of X-ray, ultrasound, CT, and MRI images | publisher = Wolters Kluwer | location = Philadelphia | year = 2016 | isbn = 9781451192209 }}