Toxic megacolon: Difference between revisions
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==[[Toxic megacolon overview|Overview]]== | ==[[Toxic megacolon overview|Overview]]== | ||
Toxic megacolon results from severe [[inflammation]] extending into the smooth-muscle layer and paralyses the colonic [[smooth muscle]] leading to [[dilatation]]. The extent of [[dilatation]] associated with the depth of [[inflammation]] and [[Ulceration|ulceratio]]<nowiki/>n. [[Nitric oxide]], an inhibitor of smooth-muscle tone, has an important role in the [[pathogenesis]] of toxic megacolon. [[Nitric oxide]] is produced by [[neutrophils]] and smooth-muscle cells in the inflamed [[colon]]. | |||
==[[Toxic megacolon historical perspective|Historical Perspective]]== | ==[[Toxic megacolon historical perspective|Historical Perspective]]== | ||
Revision as of 16:03, 29 November 2017
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Toxic Megacolon Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Toxic megacolon On the Web |
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American Roentgen Ray Society Images of Toxic megacolon |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Synonyms and keywords: Megacolon toxicum; Toxic colitis
Overview
Toxic megacolon results from severe inflammation extending into the smooth-muscle layer and paralyses the colonic smooth muscle leading to dilatation. The extent of dilatation associated with the depth of inflammation and ulceration. Nitric oxide, an inhibitor of smooth-muscle tone, has an important role in the pathogenesis of toxic megacolon. Nitric oxide is produced by neutrophils and smooth-muscle cells in the inflamed colon.
Historical Perspective
Pathophysiology
Causes
Differentiating Toxic Megacolon from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Abdominal X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies