Autoimmune hepatitis Diagnostic of choice: Difference between revisions
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(Created page with "__NOTOC__ {{Autoimmune hepatitis}} {{CMG}}; {{AE}}:{{MKK}} ==Overview== == Diagnostic Study of Choice == === Gold standard/Study of choice: === *Liver biopsy is the gold stand...") |
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**There is an abundance of plasma cells and eosinophils are usually present | **There is an abundance of plasma cells and eosinophils are usually present | ||
**Portal lesion spares the biliary tree | **Portal lesion spares the biliary tree | ||
*A plasma cell infiltrate lead to plasma cell hepatitis | *A plasma cell infiltrate lead to plasma cell hepatitis, lobular, or panacinar hepatitis | ||
*Bridging necrosis | *Bridging necrosis | ||
*Fibrosis | *Fibrosis | ||
Revision as of 02:18, 20 December 2017
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Autoimmune hepatitis Diagnostic of choice On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Diagnostic Study of Choice
Gold standard/Study of choice:
- Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis
- Liver biopsy is performed by following methods:
- Percutaneous liver biopsy with or without ultrasound guidance
- Transjugular liver biopsy
Histology findings usually found on biopsy:
- Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark
- There is lymphoplasmacytic periportal infiltrate which invade the limiting plate
- There is an abundance of plasma cells and eosinophils are usually present
- Portal lesion spares the biliary tree
- A plasma cell infiltrate lead to plasma cell hepatitis, lobular, or panacinar hepatitis
- Bridging necrosis
- Fibrosis
Fibrosis is present in most patients with autoimmune hepatitis. Without effective therapy, fibrosis starts to connect the portal and central areas, which ultimately leads to cirrhosis.