NEK2: Difference between revisions

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{{Infobox_gene}}
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'''Serine/threonine-protein kinase Nek2''' is an [[enzyme]] that in humans is encoded by the ''NEK2'' [[gene]].<ref name="pmid8274451">{{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth Differ | volume = 4 | issue = 10 | pages = 821–30 | date = Feb 1994 | pmid = 8274451 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4751| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_NEK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jav.
| PDB = {{PDB2|2jav}}
| Name = NIMA (never in mitosis gene a)-related kinase 2
| HGNCid = 7745
| Symbol = NEK2
| AltSymbols =; HsPK 21; HsPK21; NEK2A; NLK1
| OMIM = 604043
| ECnumber = 
| Homologene = 74441
| MGIid = 109359
| GeneAtlas_image1 = PBB_GE_NEK2_211080_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NEK2_204641_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0000794 |text = condensed nuclear chromosome}} {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0030496 |text = midbody}}
| Process = {{GNF_GO|id=GO:0000070 |text = mitotic sister chromatid segregation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4751
    | Hs_Ensembl = ENSG00000117650
    | Hs_RefseqProtein = NP_002488
    | Hs_RefseqmRNA = NM_002497
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 209902737
    | Hs_GenLoc_end = 209915583
    | Hs_Uniprot = P51955
    | Mm_EntrezGene = 18005
    | Mm_Ensembl = ENSMUSG00000026622
    | Mm_RefseqmRNA = NM_010892
    | Mm_RefseqProtein = NP_035022
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 193522148
    | Mm_GenLoc_end = 193533663
    | Mm_Uniprot = Q3TF15
  }}
}}
'''NIMA (never in mitosis gene a)-related kinase 2''', also known as '''NEK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4751| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
NEK2 has been shown to [[Protein-protein interaction|interact]] with [[MAPK1]]<ref name=pmid15358203>{{cite journal | vauthors = Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB | title = Nek2A specifies the centrosomal localization of Erk2 | journal = Biochem. Biophys. Res. Commun. | volume = 321 | issue = 2 | pages = 495–501 | date = Aug 2004 | pmid = 15358203 | doi = 10.1016/j.bbrc.2004.06.171 }}</ref> and [[NDC80]].<ref name=pmid12386167>{{cite journal | vauthors = Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH | title = Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49408–16 | date = Dec 2002 | pmid = 12386167 | doi = 10.1074/jbc.M207069200 }}</ref><ref name=pmid9295362>{{cite journal | vauthors = Chen Y, Sharp ZD, Lee WH | title = HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins | journal = J. Biol. Chem. | volume = 272 | issue = 38 | pages = 24081–7 | date = Sep 1997 | pmid = 9295362 | doi = 10.1074/jbc.272.38.24081 }}</ref>
{{PBB_Summary
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not [Uniprot].
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hayward DG, Fry AM | title = Nek2 kinase in chromosome instability and cancer. | journal = Cancer Lett. | volume = 237 | issue = 2 | pages = 155–66 | year = 2006 | pmid = 16084011 | doi = 10.1016/j.canlet.2005.06.017 }}
| citations =
* {{cite journal | vauthors = Schultz SJ, Fry AM, Sütterlin C, Ried T, Nigg EA | title = Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. | journal = Cell Growth Differ. | volume = 5 | issue = 6 | pages = 625–35 | year = 1994 | pmid = 7522034 | doi =  }}
*{{cite journal | author=Hayward DG, Fry AM |title=Nek2 kinase in chromosome instability and cancer. |journal=Cancer Lett. |volume=237 |issue= 2 |pages= 155-66 |year= 2006 |pmid= 16084011 |doi= 10.1016/j.canlet.2005.06.017 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Schultz SJ, Fry AM, Sütterlin C, ''et al.'' |title=Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=5 |issue= 6 |pages= 625-35 |year= 1994 |pmid= 7522034 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Fry AM, Meraldi P, Nigg EA | title = A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators | journal = EMBO J. | volume = 17 | issue = 2 | pages = 470–81 | year = 1998 | pmid = 9430639 | pmc = 1170398 | doi = 10.1093/emboj/17.2.470 }}
*{{cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi= }}
* {{cite journal | vauthors = Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA | title = C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 | journal = J. Cell Biol. | volume = 141 | issue = 7 | pages = 1563–74 | year = 1998 | pmid = 9647649 | pmc = 2133000 | doi = 10.1083/jcb.141.7.1563 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Fry AM, Arnaud L, Nigg EA | title = Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif | journal = J. Biol. Chem. | volume = 274 | issue = 23 | pages = 16304–10 | year = 1999 | pmid = 10347187 | doi = 10.1074/jbc.274.23.16304 }}
*{{cite journal | author=Fry AM, Meraldi P, Nigg EA |title=A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. |journal=EMBO J. |volume=17 |issue= 2 |pages= 470-81 |year= 1998 |pmid= 9430639 |doi= 10.1093/emboj/17.2.470 }}
* {{cite journal | vauthors = Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC | title = A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41 | journal = Genome Res. | volume = 10 | issue = 1 | pages = 81–94 | year = 2000 | pmid = 10645953 | pmc = 310500 | doi = 10.1101/gr.10.1.81 }}
*{{cite journal | author=Fry AM, Mayor T, Meraldi P, ''et al.'' |title=C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1563-74 |year= 1998 |pmid= 9647649 |doi= }}
* {{cite journal | vauthors = Helps NR, Luo X, Barker HM, Cohen PT | title = NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 | journal = Biochem. J. | volume = 349 | issue = Pt 2 | pages = 509–18 | year = 2001 | pmid = 10880350 | pmc = 1221174 | doi = 10.1042/0264-6021:3490509 }}
*{{cite journal | author=Fry AM, Arnaud L, Nigg EA |title=Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16304-10 |year= 1999 |pmid= 10347187 |doi= }}
* {{cite journal | vauthors = Hames RS, Fry AM | title = Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis | journal = Biochem. J. | volume = 361 | issue = Pt 1 | pages = 77–85 | year = 2002 | pmid = 11742531 | pmc = 1222281 | doi = 10.1042/0264-6021:3610077 }}
*{{cite journal | author=Schutte BC, Bjork BC, Coppage KB, ''et al.'' |title=A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. |journal=Genome Res. |volume=10 |issue= 1 |pages= 81-94 |year= 2000 |pmid= 10645953 |doi= }}
* {{cite journal | vauthors = Ha Kim Y, Yeol Choi J, Jeong Y, Wolgemuth DJ, Rhee K | title = Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle | journal = Biochem. Biophys. Res. Commun. | volume = 290 | issue = 2 | pages = 730–6 | year = 2002 | pmid = 11785960 | doi = 10.1006/bbrc.2001.6212 }}
*{{cite journal | author=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509-18 |year= 2001 |pmid= 10880350 |doi= }}
* {{cite journal | vauthors = Eto M, Elliott E, Prickett TD, Brautigan DL | title = Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation | journal = J. Biol. Chem. | volume = 277 | issue = 46 | pages = 44013–20 | year = 2003 | pmid = 12221103 | doi = 10.1074/jbc.M208035200 }}
*{{cite journal | author=Hames RS, Fry AM |title=Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis. |journal=Biochem. J. |volume=361 |issue= Pt 1 |pages= 77-85 |year= 2002 |pmid= 11742531 |doi= }}
* {{cite journal | vauthors = Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH | title = Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49408–16 | year = 2003 | pmid = 12386167 | doi = 10.1074/jbc.M207069200 }}
*{{cite journal | author=Ha Kim Y, Yeol Choi J, Jeong Y, ''et al.'' |title=Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 2 |pages= 730-6 |year= 2002 |pmid= 11785960 |doi= 10.1006/bbrc.2001.6212 }}
* {{cite journal | vauthors = Faragher AJ, Fry AM | title = Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles | journal = Mol. Biol. Cell | volume = 14 | issue = 7 | pages = 2876–89 | year = 2004 | pmid = 12857871 | pmc = 165683 | doi = 10.1091/mbc.E03-02-0108 }}
*{{cite journal | author=Eto M, Elliott E, Prickett TD, Brautigan DL |title=Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44013-20 |year= 2003 |pmid= 12221103 |doi= 10.1074/jbc.M208035200 }}
* {{cite journal | vauthors = Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X | title = NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling | journal = J. Biol. Chem. | volume = 279 | issue = 19 | pages = 20049–57 | year = 2004 | pmid = 14978040 | doi = 10.1074/jbc.M314205200 }}
*{{cite journal | author=Chen Y, Riley DJ, Zheng L, ''et al.'' |title=Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49408-16 |year= 2003 |pmid= 12386167 |doi= 10.1074/jbc.M207069200 }}
* {{cite journal | vauthors = Noguchi K, Fukazawa H, Murakami Y, Uehara Y | title = Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells | journal = J. Biol. Chem. | volume = 279 | issue = 31 | pages = 32716–27 | year = 2004 | pmid = 15161910 | doi = 10.1074/jbc.M404104200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM | title = Lineage-specific gene duplication and loss in human and great ape evolution | journal = PLoS Biol. | volume = 2 | issue = 7 | pages = E207 | year = 2006 | pmid = 15252450 | pmc = 449870 | doi = 10.1371/journal.pbio.0020207 }}
*{{cite journal | author=Faragher AJ, Fry AM |title=Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2876-89 |year= 2004 |pmid= 12857871 |doi= 10.1091/mbc.E03-02-0108 }}
* {{cite journal | vauthors = Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB | title = Nek2A specifies the centrosomal localization of Erk2 | journal = Biochem. Biophys. Res. Commun. | volume = 321 | issue = 2 | pages = 495–501 | year = 2004 | pmid = 15358203 | doi = 10.1016/j.bbrc.2004.06.171 }}
*{{cite journal | author=Lou Y, Yao J, Zereshki A, ''et al.'' |title=NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20049-57 |year= 2004 |pmid= 14978040 |doi= 10.1074/jbc.M314205200 }}
*{{cite journal | author=Noguchi K, Fukazawa H, Murakami Y, Uehara Y |title=Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32716-27 |year= 2004 |pmid= 15161910 |doi= 10.1074/jbc.M404104200 }}
*{{cite journal  | author=Fortna A, Kim Y, MacLaren E, ''et al.'' |title=Lineage-specific gene duplication and loss in human and great ape evolution. |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 }}
*{{cite journal  | author=Lou Y, Xie W, Zhang DF, ''et al.'' |title=Nek2A specifies the centrosomal localization of Erk2. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 495-501 |year= 2004 |pmid= 15358203 |doi= 10.1016/j.bbrc.2004.06.171 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Revision as of 12:49, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.[1][2]

Interactions

NEK2 has been shown to interact with MAPK1[3] and NDC80.[4][5] Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not [Uniprot].

References

  1. ↑ Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  2. ↑ "Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2".
  3. ↑ Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB (Aug 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. 321 (2): 495–501. doi:10.1016/j.bbrc.2004.06.171. PMID 15358203.
  4. ↑ Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". J. Biol. Chem. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167.
  5. ↑ Chen Y, Sharp ZD, Lee WH (Sep 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. PMID 9295362.

Further reading


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