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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1''' is a [[protein]] that in humans is encoded by the ''GNB1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2782| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GNB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a0r.
| PDB = {{PDB2|1a0r}}, {{PDB2|1b9x}}, {{PDB2|1b9y}}, {{PDB2|1gg2}}, {{PDB2|1got}}, {{PDB2|1gp2}}, {{PDB2|1omw}}, {{PDB2|1tbg}}, {{PDB2|1xhm}}, {{PDB2|2bcj}}, {{PDB2|2trc}}
| Name = Guanine nucleotide binding protein (G protein), beta polypeptide 1
| HGNCid = 4396
| Symbol = GNB1
| AltSymbols =;
| OMIM = 139380
| ECnumber = 
| Homologene = 55532
| MGIid = 95781
| GeneAtlas_image1 = PBB_GE_GNB1_200745_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNB1_200744_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNB1_200746_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2782
    | Hs_Ensembl = ENSG00000078369
    | Hs_RefseqProtein = NP_002065
    | Hs_RefseqmRNA = NM_002074
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 1706589
    | Hs_GenLoc_end = 1812355
    | Hs_Uniprot = P62873
    | Mm_EntrezGene = 14688
    | Mm_Ensembl = ENSMUSG00000029064
    | Mm_RefseqmRNA = NM_008142
    | Mm_RefseqProtein = NP_032168
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 154335170
    | Mm_GenLoc_end = 154401618
    | Mm_Uniprot = Q3TQ70
  }}
}}
'''Guanine nucleotide binding protein (G protein), beta polypeptide 1''', also known as '''GNB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2782| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.<ref name="entrez">{{cite web | title = Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2782| accessdate = }}</ref>
}}


==References==
== Interactive pathway map ==
{{reflist|2}}
{{NicotineDopaminergicActivity_WP1602|highlight=GNB1}}
==Further reading==
 
== Interactions ==
 
GNB1 has been shown to [[Protein-protein interaction|interact]] with [[GNG4]].<ref name=pmid7665596>{{cite journal | vauthors = Ray K, Kunsch C, Bonner LM, Robishaw JD | title = Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21765–71  | date = September 1995 | pmid = 7665596 | doi = 10.1074/jbc.270.37.21765 }}</ref><ref name=pmid8636150>{{cite journal | vauthors = Yan K, Kalyanaraman V, Gautam N | title = Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7141–6  | date = March 1996 | pmid = 8636150 | doi = 10.1074/jbc.271.12.7141 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 | year = 1999 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}
| citations =
* {{cite journal | vauthors = Levine MA, Modi WS, O'Brien SJ | title = Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man | journal = Genomics | volume = 8 | issue = 2 | pages = 380–6 | year = 1990 | pmid = 1979057 | doi = 10.1016/0888-7543(90)90296-7 }}
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544-52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
* {{cite journal | vauthors = Codina J, Stengel D, Woo SL, Birnbaumer L | title = Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical | journal = FEBS Lett. | volume = 207 | issue = 2 | pages = 187–92 | year = 1986 | pmid = 3095147 | doi = 10.1016/0014-5793(86)81486-7 }}
*{{cite journal | author=Levine MA, Modi WS, O'Brien SJ |title=Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man. |journal=Genomics |volume=8 |issue= 2 |pages= 380-6 |year= 1991 |pmid= 1979057 |doi= }}
* {{cite journal | vauthors = Buhl AM, Osawa S, Johnson GL | title = Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor | journal = J. Biol. Chem. | volume = 270 | issue = 34 | pages = 19828–32 | year = 1995 | pmid = 7649993 | doi = 10.1074/jbc.270.34.19828 }}
*{{cite journal | author=Codina J, Stengel D, Woo SL, Birnbaumer L |title=Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. |journal=FEBS Lett. |volume=207 |issue= 2 |pages= 187-92 |year= 1986 |pmid= 3095147 |doi= }}
* {{cite journal | vauthors = Ray K, Kunsch C, Bonner LM, Robishaw JD | title = Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21765–71 | year = 1995 | pmid = 7665596 | doi = 10.1074/jbc.270.37.21765 }}
*{{cite journal | author=Buhl AM, Osawa S, Johnson GL |title=Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 19828-32 |year= 1995 |pmid= 7649993 |doi= }}
* {{cite journal | vauthors = Kozasa T, Gilman AG | title = Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z | journal = J. Biol. Chem. | volume = 270 | issue = 4 | pages = 1734–41 | year = 1995 | pmid = 7829508 | doi = 10.1074/jbc.270.4.1734 }}
*{{cite journal | author=Ray K, Kunsch C, Bonner LM, Robishaw JD |title=Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21765-71 |year= 1995 |pmid= 7665596 |doi= }}
* {{cite journal | vauthors = Tsukada S, Simon MI, Witte ON, Katz A | title = Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 23 | pages = 11256–60 | year = 1994 | pmid = 7972043 | pmc = 45206 | doi = 10.1073/pnas.91.23.11256 }}
*{{cite journal | author=Kozasa T, Gilman AG |title=Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1734-41 |year= 1995 |pmid= 7829508 |doi= }}
* {{cite journal | vauthors = Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG | title = G protein beta gamma subunits. Simplified purification and properties of novel isoforms | journal = J. Biol. Chem. | volume = 269 | issue = 6 | pages = 4388–95 | year = 1994 | pmid = 8308009 | doi =  }}
*{{cite journal | author=Tsukada S, Simon MI, Witte ON, Katz A |title=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 11256-60 |year= 1994 |pmid= 7972043 |doi= }}
* {{cite journal | vauthors = Wall MA, Coleman DE, Lee E, Iñiguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR | title = The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2 | journal = Cell | volume = 83 | issue = 6 | pages = 1047–58 | year = 1995 | pmid = 8521505 | doi = 10.1016/0092-8674(95)90220-1 }}
*{{cite journal | author=Ueda N, Iñiguez-Lluhi JA, Lee E, ''et al.'' |title=G protein beta gamma subunits. Simplified purification and properties of novel isoforms. |journal=J. Biol. Chem. |volume=269 |issue= 6 |pages= 4388-95 |year= 1994 |pmid= 8308009 |doi=  }}
* {{cite journal | vauthors = Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB | title = Crystal structure of a G-protein beta gamma dimer at 2.1A resolution | journal = Nature | volume = 379 | issue = 6563 | pages = 369–74 | year = 1996 | pmid = 8552196 | doi = 10.1038/379369a0 }}
*{{cite journal | author=Wall MA, Coleman DE, Lee E, ''et al.'' |title=The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. |journal=Cell |volume=83 |issue= 6 |pages= 1047-58 |year= 1996 |pmid= 8521505 |doi= }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Sondek J, Bohm A, Lambright DG, ''et al.'' |title=Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. |journal=Nature |volume=379 |issue= 6563 |pages= 369-74 |year= 1996 |pmid= 8552196 |doi= 10.1038/379369a0 }}
* {{cite journal | vauthors = Mattingly RR, Macara IG | title = Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits | journal = Nature | volume = 382 | issue = 6588 | pages = 268–72 | year = 1996 | pmid = 8717044 | doi = 10.1038/382268a0 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = De Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP | title = Direct binding of G-protein betagamma complex to voltage-dependent calcium channels | journal = Nature | volume = 385 | issue = 6615 | pages = 446–50 | year = 1997 | pmid = 9009193 | doi = 10.1038/385446a0 }}
*{{cite journal | author=Mattingly RR, Macara IG |title=Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. |journal=Nature |volume=382 |issue= 6588 |pages= 268-72 |year= 1996 |pmid= 8717044 |doi= 10.1038/382268a0 }}
* {{cite journal | vauthors = Huang CL, Jan YN, Jan LY | title = Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels | journal = FEBS Lett. | volume = 405 | issue = 3 | pages = 291–8 | year = 1997 | pmid = 9108307 | doi = 10.1016/S0014-5793(97)00197-X }}
*{{cite journal | author=De Waard M, Liu H, Walker D, ''et al.'' |title=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels. |journal=Nature |volume=385 |issue= 6615 |pages= 446-50 |year= 1997 |pmid= 9009193 |doi= 10.1038/385446a0 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291-8 |year= 1997 |pmid= 9108307 |doi= }}
* {{cite journal | vauthors = Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L | title = Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8866–71 | year = 1997 | pmid = 9238069 | pmc = 23172 | doi = 10.1073/pnas.94.16.8866 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Nishida K, Kaziro Y, Satoh T | title = Association of the proto-oncogene product dbl with G protein betagamma subunits | journal = FEBS Lett. | volume = 459 | issue = 2 | pages = 186–90 | year = 1999 | pmid = 10518015 | doi = 10.1016/S0014-5793(99)01244-2 }}
*{{cite journal | author=Qin N, Platano D, Olcese R, ''et al.'' |title=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8866-71 |year= 1997 |pmid= 9238069 |doi= }}
* {{cite journal | vauthors = Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF | title = Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium | journal = Nat. Neurosci. | volume = 2 | issue = 12 | pages = 1055–62 | year = 1999 | pmid = 10570481 | doi = 10.1038/15981 }}
*{{cite journal | author=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186-90 |year= 1999 |pmid= 10518015 |doi= }}
* {{cite journal | vauthors = Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL | title = Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2 | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10443–52 | year = 2000 | pmid = 10744734 | doi = 10.1074/jbc.275.14.10443 }}
*{{cite journal | author=Huang L, Shanker YG, Dubauskaite J, ''et al.'' |title=Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. |journal=Nat. Neurosci. |volume=2 |issue= 12 |pages= 1055-62 |year= 2000 |pmid= 10570481 |doi= 10.1038/15981 }}
*{{cite journal | author=Carman CV, Barak LS, Chen C, ''et al.'' |title=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10443-52 |year= 2000 |pmid= 10744734 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-1-stub}}
{{WikiDoc Sources}}
 
{{PDB Gallery|geneid=2782}}
{{Intracellular signaling peptides and proteins}}

Revision as of 08:51, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[1]

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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<imagemap> Image:NicotineDopaminergic_WP1602.png
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<imagemap> Image:NicotineDopaminergic_WP1602.png
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Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNB1 has been shown to interact with GNG4.[2][3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1".
  2. ↑ Ray K, Kunsch C, Bonner LM, Robishaw JD (September 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
  3. ↑ Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GNB1&oldid=1410988"