TANK (gene): Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''TRAF family member-associated NF-kappa-B activator''' is a [[protein]] that in humans is encoded by the ''TANK'' [[gene]].<ref name="pmid8710854">{{cite journal | vauthors = Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV | title = I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8241–6 | date = August 1996 | pmid = 8710854 | pmc = 38654 | doi = 10.1073/pnas.93.16.8241 }}</ref><ref name="pmid8855313">{{cite journal | vauthors = Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G | title = Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 20 | pages = 11085–90 | date = October 1996 | pmid = 8855313 | pmc = 38288 | doi = 10.1073/pnas.93.20.11085 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TRAF family member-associated NFKB activator
| HGNCid = 11562
| Symbol = TANK
| AltSymbols =; TRAF2; I-TRAF
| OMIM = 603893
| ECnumber = 
| Homologene = 3081
| MGIid = 107676
| GeneAtlas_image1 = PBB_GE_TANK_209451_at_tn.png
| GeneAtlas_image2 = PBB_GE_TANK_207616_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TANK_210458_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10010
    | Hs_Ensembl = ENSG00000136560
    | Hs_RefseqProtein = NP_004171
    | Hs_RefseqmRNA = NM_004180
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 161701712
    | Hs_GenLoc_end = 161800928
    | Hs_Uniprot = Q92844
    | Mm_EntrezGene = 21353
    | Mm_Ensembl = ENSMUSG00000064289
    | Mm_RefseqmRNA = NM_011529
    | Mm_RefseqProtein = NP_035659
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 61379422
    | Mm_GenLoc_end = 61454950
    | Mm_Uniprot = Q3TNB4
  }}
}}
'''TRAF family member-associated NFKB activator''', also known as '''TANK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TANK (gene) has been shown to [[Protein-protein interaction|interact]] with [[TANK-binding kinase 1]],<ref name=pmid14743216>{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}</ref><ref name=pmid10581243>{{cite journal | vauthors = Pomerantz JL, Baltimore D | title = NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase | journal = The EMBO Journal | volume = 18 | issue = 23 | pages = 6694–704 | date = December 1999 | pmid = 10581243 | pmc = 1171732 | doi = 10.1093/emboj/18.23.6694 }}</ref> [[IKBKE]],<ref name=pmid10759890>{{cite journal | vauthors = Nomura F, Kawai T, Nakanishi K, Akira S | title = NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation | journal = Genes to Cells | volume = 5 | issue = 3 | pages = 191–202 | date = March 2000 | pmid = 10759890 | doi = 10.1046/j.1365-2443.2000.00315.x }}</ref> [[TRAF2]],<ref name=pmid8710854 /><ref name=pmid14743216/><ref name=pmid10581243/><ref name=pmid10759890/> [[IKBKG]]<ref name=pmid12133833>{{cite journal | vauthors = Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U | title = Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37029–36 | date = October 2002 | pmid = 12133833 | doi = 10.1074/jbc.M205069200 }}</ref> and [[TRAF3]].<ref name=pmid8710854/><ref name=pmid14743216/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chin AI, Shu J, Shan Shi C, Yao Z, Kehrl JH, Cheng G | title = TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6665–72 | date = October 1999 | pmid = 10490605 | pmc = 84649 | doi =  }}
| citations =
* {{cite journal | vauthors = Pomerantz JL, Baltimore D | title = NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase | journal = The EMBO Journal | volume = 18 | issue = 23 | pages = 6694–704 | date = December 1999 | pmid = 10581243 | pmc = 1171732 | doi = 10.1093/emboj/18.23.6694 }}
*{{cite journal  | author=Rothe M, Xiong J, Shu HB, ''et al.'' |title=I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8241-6 |year= 1996 |pmid= 8710854 |doi=  }}
* {{cite journal | vauthors = Nomura F, Kawai T, Nakanishi K, Akira S | title = NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation | journal = Genes to Cells | volume = 5 | issue = 3 | pages = 191–202 | date = March 2000 | pmid = 10759890 | doi = 10.1046/j.1365-2443.2000.00315.x }}
*{{cite journal | author=Kaye KM, Devergne O, Harada JN, ''et al.'' |title=Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 11085-90 |year= 1996 |pmid= 8855313 |doi=  }}
* {{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = June 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}
*{{cite journal  | author=Chin AI, Shu J, Shan Shi C, ''et al.'' |title=TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6665-72 |year= 2000 |pmid= 10490605 |doi=  }}
* {{cite journal | vauthors = Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR | title = Downstream regulator TANK binds to the CD40 recognition site on TRAF3 | journal = Structure | volume = 10 | issue = 3 | pages = 403–11 | date = March 2002 | pmid = 12005438 | doi = 10.1016/S0969-2126(02)00733-5 }}
*{{cite journal | author=Pomerantz JL, Baltimore D |title=NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. |journal=EMBO J. |volume=18 |issue= 23 |pages= 6694-704 |year= 2000 |pmid= 10581243 |doi= 10.1093/emboj/18.23.6694 }}
* {{cite journal | vauthors = Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U | title = Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37029–36 | date = October 2002 | pmid = 12133833 | doi = 10.1074/jbc.M205069200 }}
*{{cite journal | author=Nomura F, Kawai T, Nakanishi K, Akira S |title=NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. |journal=Genes Cells |volume=5 |issue= 3 |pages= 191-202 |year= 2000 |pmid= 10759890 |doi= }}
* {{cite journal | vauthors = Ishida R, Ezura Y, Emi M, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H | title = Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women | journal = Bone | volume = 33 | issue = 2 | pages = 237–41 | date = August 2003 | pmid = 14499357 | doi = 10.1016/S8756-3282(03)00226-6 }}
*{{cite journal | author=Zapata JM, Pawlowski K, Haas E, ''et al.'' |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242-52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200 }}
* {{cite journal | vauthors = Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR | title = Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50523–9 | date = December 2003 | pmid = 14517219 | doi = 10.1074/jbc.M309381200 }}
*{{cite journal | author=Li C, Ni CZ, Havert ML, ''et al.'' |title=Downstream regulator TANK binds to the CD40 recognition site on TRAF3. |journal=Structure |volume=10 |issue= 3 |pages= 403-11 |year= 2002 |pmid= 12005438 |doi= }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Chariot A, Leonardi A, Muller J, ''et al.'' |title=Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37029-36 |year= 2002 |pmid= 12133833 |doi= 10.1074/jbc.M205069200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bonif M, Meuwis MA, Close P, Benoit V, Heyninck K, Chapelle JP, Bours V, Merville MP, Piette J, Beyaert R, Chariot A | title = TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation | journal = The Biochemical Journal | volume = 394 | issue = Pt 3 | pages = 593–603 | date = March 2006 | pmid = 16336209 | pmc = 1383709 | doi = 10.1042/BJ20051659 }}
*{{cite journal  | author=Ishida R, Ezura Y, Emi M, ''et al.'' |title=Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women. |journal=Bone |volume=33 |issue= 2 |pages= 237-41 |year= 2004 |pmid= 14499357 |doi= }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Li C, Norris PS, Ni CZ, ''et al.'' |title=Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50523-9 |year= 2004 |pmid= 14517219 |doi= 10.1074/jbc.M309381200 }}
* {{cite journal | vauthors = Guo B, Cheng G | title = Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK | journal = The Journal of Biological Chemistry | volume = 282 | issue = 16 | pages = 11817–26 | date = April 2007 | pmid = 17327220 | doi = 10.1074/jbc.M700017200 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
* {{cite journal | vauthors = Ryzhakov G, Randow F | title = SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK | journal = The EMBO Journal | volume = 26 | issue = 13 | pages = 3180–90 | date = July 2007 | pmid = 17568778 | pmc = 1914091 | doi = 10.1038/sj.emboj.7601743 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A | title = Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF | journal = The Journal of Biological Chemistry | volume = 282 | issue = 43 | pages = 31131–46 | date = October 2007 | pmid = 17823124 | doi = 10.1074/jbc.M701690200 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Bonif M, Meuwis MA, Close P, ''et al.'' |title=TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 593-603 |year= 2006 |pmid= 16336209 |doi= 10.1042/BJ20051659 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Guo B, Cheng G |title=Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 11817-26 |year= 2007 |pmid= 17327220 |doi= 10.1074/jbc.M700017200 }}
*{{cite journal | author=Ryzhakov G, Randow F |title=SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. |journal=EMBO J. |volume=26 |issue= 13 |pages= 3180-90 |year= 2007 |pmid= 17568778 |doi= 10.1038/sj.emboj.7601743 }}
*{{cite journal | author=Gatot JS, Gioia R, Chau TL, ''et al.'' |title=Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. |journal=J. Biol. Chem. |volume=282 |issue= 43 |pages= 31131-46 |year= 2007 |pmid= 17823124 |doi= 10.1074/jbc.M701690200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|TANK}}
* {{UCSC gene details|TANK}}
 
{{gene-2-stub}}

Latest revision as of 11:33, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.[1][2][3]

Function

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1,[4][5] IKBKE,[6] TRAF2,[1][4][5][6] IKBKG[7] and TRAF3.[1][4]

References

  1. ↑ 1.0 1.1 1.2 Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
  2. ↑ Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (October 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 11085–90. doi:10.1073/pnas.93.20.11085. PMC 38288. PMID 8855313.
  3. ↑ 3.0 3.1 "Entrez Gene: TANK TRAF family member-associated NFKB activator".
  4. ↑ 4.0 4.1 4.2 Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  5. ↑ 5.0 5.1 Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
  6. ↑ 6.0 6.1 Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890.
  7. ↑ Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=TANK_(gene)&oldid=1412328"