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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sorting nexin-17''' is a [[protein]] that in humans is encoded by the ''SNX17'' [[gene]].<ref name="pmid12169628">{{cite journal | vauthors = Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J | title = The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor | journal = EMBO J. | volume = 21 | issue = 16 | pages = 4259–67  | date = Aug 2002 | pmid = 12169628 | pmc = 126172 | doi = 10.1093/emboj/cdf435 }}</ref><ref name="pmid15769472">{{cite journal | vauthors = Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R | title = Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking | journal = J. Mol. Biol. | volume = 347 | issue = 4 | pages = 813–25  | date = Mar 2005 | pmid = 15769472 | pmc =  | doi = 10.1016/j.jmb.2005.02.004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNX17 sorting nexin 17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9784| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sorting nexin 17
| HGNCid = 14979
| Symbol = SNX17
| AltSymbols =; KIAA0064
| OMIM = 605963
| ECnumber = 
| Homologene = 8838
| MGIid = 2387801
| GeneAtlas_image1 = PBB_GE_SNX17_200991_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016197 |text = endosome transport}} {{GNF_GO|id=GO:0030100 |text = regulation of endocytosis}} {{GNF_GO|id=GO:0045192 |text = low-density lipoprotein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9784
    | Hs_Ensembl = ENSG00000115234
    | Hs_RefseqProtein = NP_055563
    | Hs_RefseqmRNA = NM_014748
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 27446893
    | Hs_GenLoc_end = 27453499
    | Hs_Uniprot = Q15036
    | Mm_EntrezGene = 266781
    | Mm_Ensembl = ENSMUSG00000029146
    | Mm_RefseqmRNA = NM_153680
    | Mm_RefseqProtein = NP_710147
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 31469876
    | Mm_GenLoc_end = 31475480
    | Mm_Uniprot = Q8BVL3
  }}
}}
'''Sorting nexin 17''', also known as '''SNX17''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNX17 sorting nexin 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9784| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.<ref name="entrez">{{cite web | title = Entrez Gene: SNX17 sorting nexin 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9784| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SNX17 has been shown to [[Protein-protein interaction|interact]] with [[Low density lipoprotein receptor-related protein 8]]<ref name=pmid12169628 />
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 1 | issue = 5 | pages = 223–9 | year = 1994 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Hoja MR, Wahlestedt C, Höög C | title = A visual intracellular classification strategy for uncharacterized human proteins | journal = Exp. Cell Res. | volume = 259 | issue = 1 | pages = 239–46 | year = 2000 | pmid = 10942595 | doi = 10.1006/excr.2000.4948 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Florian V, Schlüter T, Bohnensack R | title = A new member of the sorting nexin family interacts with the C-terminus of P-selectin | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 4 | pages = 1045–50 | year = 2001 | pmid = 11237770 | doi = 10.1006/bbrc.2001.4467 }}
*{{cite journal | author=Hoja MR, Wahlestedt C, Höög C |title=A visual intracellular classification strategy for uncharacterized human proteins. |journal=Exp. Cell Res. |volume=259 |issue= 1 |pages= 239-46 |year= 2000 |pmid= 10942595 |doi= 10.1006/excr.2000.4948 }}
* {{cite journal | vauthors = Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA | title = A large family of endosome-localized proteins related to sorting nexin 1 | journal = Biochem. J. | volume = 358 | issue = Pt 1 | pages = 7–16 | year = 2001 | pmid = 11485546 | pmc = 1222026 | doi = 10.1042/0264-6021:3580007 }}
*{{cite journal | author=Florian V, Schlüter T, Bohnensack R |title=A new member of the sorting nexin family interacts with the C-terminus of P-selectin. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 4 |pages= 1045-50 |year= 2001 |pmid= 11237770 |doi= 10.1006/bbrc.2001.4467 }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Teasdale RD, Loci D, Houghton F, ''et al.'' |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7-16 |year= 2001 |pmid= 11485546 |doi=  }}
* {{cite journal | vauthors = Burden JJ, Sun XM, García AB, Soutar AK | title = Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17 | journal = J. Biol. Chem. | volume = 279 | issue = 16 | pages = 16237–45 | year = 2004 | pmid = 14739284 | doi = 10.1074/jbc.M313689200 }}
*{{cite journal  | author=Stockinger W, Sailler B, Strasser V, ''et al.'' |title=The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. |journal=EMBO J. |volume=21 |issue= 16 |pages= 4259-67 |year= 2002 |pmid= 12169628 |doi=  }}
* {{cite journal | vauthors = Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF | title = Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin | journal = Mol. Biol. Cell | volume = 15 | issue = 7 | pages = 3095–105 | year = 2004 | pmid = 15121882 | pmc = 452567 | doi = 10.1091/mbc.E04-02-0143 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G | title = Sorting nexin 17 facilitates LRP recycling in the early endosome | journal = EMBO J. | volume = 24 | issue = 16 | pages = 2851–61 | year = 2005 | pmid = 16052210 | pmc = 1187941 | doi = 10.1038/sj.emboj.7600756 }}
*{{cite journal | author=Burden JJ, Sun XM, García AB, Soutar AK |title=Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16237-45 |year= 2004 |pmid= 14739284 |doi= 10.1074/jbc.M313689200 }}
* {{cite journal | vauthors = Czubayko M, Knauth P, Schlüter T, Florian V, Bohnensack R | title = Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1 | journal = Biochem. Biophys. Res. Commun. | volume = 345 | issue = 3 | pages = 1264–72 | year = 2006 | pmid = 16712798 | doi = 10.1016/j.bbrc.2006.04.129 }}
*{{cite journal | author=Williams R, Schlüter T, Roberts MS, ''et al.'' |title=Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. |journal=Mol. Biol. Cell |volume=15 |issue= 7 |pages= 3095-105 |year= 2005 |pmid= 15121882 |doi= 10.1091/mbc.E04-02-0143 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Knauth P, Schlüter T, Czubayko M, ''et al.'' |title=Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking. |journal=J. Mol. Biol. |volume=347 |issue= 4 |pages= 813-25 |year= 2005 |pmid= 15769472 |doi= 10.1016/j.jmb.2005.02.004 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=van Kerkhof P, Lee J, McCormick L, ''et al.'' |title=Sorting nexin 17 facilitates LRP recycling in the early endosome. |journal=EMBO J. |volume=24 |issue= 16 |pages= 2851-61 |year= 2006 |pmid= 16052210 |doi= 10.1038/sj.emboj.7600756 }}
*{{cite journal | author=Czubayko M, Knauth P, Schlüter T, ''et al.'' |title=Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 3 |pages= 1264-72 |year= 2006 |pmid= 16712798 |doi= 10.1016/j.bbrc.2006.04.129 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Sorting nexins}}
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 06:47, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.[1][2][3]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.[3]

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8[1]

References

  1. ↑ 1.0 1.1 Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172. PMID 12169628.
  2. ↑ Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472.
  3. ↑ 3.0 3.1 "Entrez Gene: SNX17 sorting nexin 17".

Further reading


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