OR6A2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Olfactory receptor 6A2''' is a [[protein]] that in humans is encoded by the ''OR6A2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8590| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 6, subfamily A, member 2
| HGNCid = 15301
| Symbol = OR6A2
| AltSymbols =; I7; MGC126538; MGC126540; OR11-55; OR6A1; OR6A2P
| OMIM = 608495
| ECnumber = 
| Homologene = 2743
| MGIid = 97432
| GeneAtlas_image1 = PBB_GE_OR6A2_221465_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8590
    | Hs_Ensembl = ENSG00000184933
    | Hs_RefseqProtein = NP_003687
    | Hs_RefseqmRNA = NM_003696
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 6772532
    | Hs_GenLoc_end = 6773515
    | Hs_Uniprot = O95222
    | Mm_EntrezGene = 18317
    | Mm_Ensembl = ENSMUSG00000070417
    | Mm_RefseqmRNA = NM_010983
    | Mm_RefseqProtein = NP_035113
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 106794524
    | Mm_GenLoc_end = 106795507
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 6, subfamily A, member 2''', also known as '''OR6A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8590| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Olfactory receptor]]s interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of [[G-protein-coupled receptor]]s (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the [[genome]]. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8590| accessdate = }}</ref>
 
}}
Variation in the OR6A2 gene has been identified as a likely cause of some people's strong dislike of [[coriander]] (also known as cilantro)<ref name=Eriksson_2012>{{cite journal | author = Eriksson N | title = A genetic variant near olfactory receptor genes influences cilantro preference | journal = Flavour |date= 29 November 2012 | doi = 10.1186/2044-7248-1-22 |name-list-format=vanc| author2=Wu S  | author3=Chuong BD  | display-authors=3  | author4=Kiefer AK  | author5=Tuing JY  | author6=Mountain JL  | author7=Hinds DA | author8=Francke U. }}</ref>, often associating it with a combination of [[soap]] and [[Vomiting|vomit]], while for others it is closer to the foul smelling odor emitted by [[Pentatomidae|stinkbugs]]. This is due to the presence of [[aldehyde]] chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and [[cinnamon]].<ref name=Callaway_2012>{{cite journal | author = Callaway E | title = Soapy taste of coriander linked to genetic variants | journal = Nature |date=September 2012 | doi = 10.1038/nature.2012.11398 }}</ref>


==See also==
==See also==
Line 58: Line 14:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Buettner JA |title=Organization and evolution of olfactory receptor genes on human chromosome 11 |journal=Genomics |volume=53 |issue= 1 |pages= 56–68 |year= 1998 |pmid= 9787077 |doi= 10.1006/geno.1998.5422 |name-list-format=vanc| author2=Glusman G  | author3=Ben-Arie N  | display-authors=3  | last4=Ramos  | first4=Purita  | last5=Lancet  | first5=Doron  | last6=Evans  | first6=Glen A. }}
| citations =
*{{cite journal  | author=Lane RP |title=Genomic analysis of orthologous mouse and human olfactory receptor loci |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7390–5 |year= 2001 |pmid= 11416212 |doi= 10.1073/pnas.131215398 | pmc=34679  |name-list-format=vanc| author2=Cutforth T  | author3=Young J  | display-authors=3  | last4=Athanasiou  | first4=M  | last5=Friedman  | first5=C  | last6=Rowen  | first6=L  | last7=Evans  | first7=G  | last8=Axel  | first8=R  | last9=Hood  | first9=L }}
*{{cite journal  | author=Buettner JA, Glusman G, Ben-Arie N, ''et al.'' |title=Organization and evolution of olfactory receptor genes on human chromosome 11. |journal=Genomics |volume=53 |issue= 1 |pages= 56-68 |year= 1998 |pmid= 9787077 |doi= 10.1006/geno.1998.5422 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Lane RP, Cutforth T, Young J, ''et al.'' |title=Genomic analysis of orthologous mouse and human olfactory receptor loci. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7390-5 |year= 2001 |pmid= 11416212 |doi= 10.1073/pnas.131215398 }}
*{{cite journal  |vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
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{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:Olfactory receptors]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 00:31, 7 September 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.[1]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

Clinical significance

Variation in the OR6A2 gene has been identified as a likely cause of some people's strong dislike of coriander (also known as cilantro)[2], often associating it with a combination of soap and vomit, while for others it is closer to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and cinnamon.[3]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
  2. ↑ Eriksson N, Wu S, Chuong BD, et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. doi:10.1186/2044-7248-1-22.
  3. ↑ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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