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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2''' is an [[enzyme]] that in humans is encoded by the ''PLCB2'' [[gene]].<ref name="pmid1644792">{{cite journal | vauthors = Park D, Jhon DY, Kriz R, Knopf J, Rhee SG | title = Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2 | journal = J. Biol. Chem. | volume = 267 | issue = 23 | pages = 16048–55  | date = Sep 1992 | pmid = 1644792 | pmc =  | doi =  }}</ref><ref name="pmid9925923">{{cite journal | vauthors = Park SH, Ryu SH, Suh PG, Kim H | title = Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 83 | issue = 1-2 | pages = 48–9 | date = Mar 1999 | pmid = 9925923 | pmc = | doi = 10.1159/000015166 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCB2 phospholipase C, beta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5330| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PLCB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fju.
| PDB = {{PDB2|2fju}}
| Name = Phospholipase C, beta 2
| HGNCid = 9055
| Symbol = PLCB2
| AltSymbols =; FLJ38135
| OMIM = 604114
| ECnumber = 
| Homologene = 20957
| MGIid = 107465
| GeneAtlas_image1 = PBB_GE_PLCB2_204046_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5330
    | Hs_Ensembl = ENSG00000137841
    | Hs_RefseqProtein = NP_004564
    | Hs_RefseqmRNA = NM_004573
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 38367402
    | Hs_GenLoc_end = 38387330
    | Hs_Uniprot = Q00722
    | Mm_EntrezGene = 18796
    | Mm_Ensembl = ENSMUSG00000040061
    | Mm_RefseqmRNA = NM_177568
    | Mm_RefseqProtein = NP_808236
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 118398958
    | Mm_GenLoc_end = 118419879
    | Mm_Uniprot = 
  }}
}}
'''Phospholipase C, beta 2''', also known as '''PLCB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCB2 phospholipase C, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5330| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The gene codes for the enzyme [[phospholipase C]] β2. The enzyme catalyzes the formation of [[inositol 1,4,5-trisphosphate]] and [[diacylglycerol]] from [[phosphatidylinositol 4,5-bisphosphate]]. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two [[G-protein]] alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLCB2 has been shown to [[Protein-protein interaction|interact]] with [[MAP2K3]]<ref name=pmid12054652>{{cite journal | vauthors = Barr AJ, Marjoram R, Xu J, Snyderman R | title = Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3 | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 1 | pages = 647–52  | date = Apr 2002 | pmid = 12054652 | doi = 10.1016/S0006-291X(02)00259-0 }}</ref> and [[TRPM7]].<ref name=pmid11941371>{{cite journal | vauthors = Runnels LW, Yue L, Clapham DE | title = The TRPM7 channel is inactivated by PIP(2) hydrolysis | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 329–36  | date = May 2002 | pmid = 11941371 | doi = 10.1038/ncb781 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = J. Clin. Invest. | volume = 86 | issue = 6 | pages = 2117–24 | year = 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
| citations =
* {{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = Eur. J. Immunol. | volume = 25 | issue = 9 | pages = 2695–700 | year = 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 }}
*{{cite journal | author=Park D, Jhon DY, Kriz R, ''et al.'' |title=Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. |journal=J. Biol. Chem. |volume=267 |issue= 23 |pages= 16048-55 |year= 1992 |pmid= 1644792 |doi= }}
* {{cite journal | vauthors = Buhl AM, Osawa S, Johnson GL | title = Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor | journal = J. Biol. Chem. | volume = 270 | issue = 34 | pages = 19828–32 | year = 1995 | pmid = 7649993 | doi = 10.1074/jbc.270.34.19828 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi= }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi= }}
* {{cite journal | vauthors = Darè E, Kifor O, Brown EM, Weber G | title = Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor | journal = J. Mol. Endocrinol. | volume = 21 | issue = 1 | pages = 7–17 | year = 1998 | pmid = 9723859 | doi = 10.1677/jme.0.0210007 }}
*{{cite journal | author=Buhl AM, Osawa S, Johnson GL |title=Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 19828-32 |year= 1995 |pmid= 7649993 |doi= }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3-4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi= }}
* {{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = J. Neurochem. | volume = 73 | issue = 4 | pages = 1363–74 | year = 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Darè E, Kifor O, Brown EM, Weber G |title=Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor. |journal=J. Mol. Endocrinol. |volume=21 |issue= 1 |pages= 7-17 |year= 1998 |pmid= 9723859 |doi= }}
* {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = J. Immunol. | volume = 164 | issue = 12 | pages = 6538–42 | year = 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi= }}
* {{cite journal | vauthors = Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX | title = Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37559–64 | year = 2000 | pmid = 10980202 | doi = 10.1074/jbc.M006635200 }}
*{{cite journal | author=Park SH, Ryu SH, Suh PG, Kim H |title=Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 48-9 |year= 1999 |pmid= 9925923 |doi= }}
* {{cite journal | vauthors = Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC | title = Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) | journal = Biochim. Biophys. Acta | volume = 1517 | issue = 1 | pages = 63–72 | year = 2000 | pmid = 11118617 | doi = 10.1016/S0167-4781(00)00260-8 }}
*{{cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi= }}
* {{cite journal | vauthors = Singer AU, Waldo GL, Harden TK, Sondek J | title = A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q | journal = Nat. Struct. Biol. | volume = 9 | issue = 1 | pages = 32–6 | year = 2002 | pmid = 11753430 | doi = 10.1038/nsb731 }}
*{{cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi= }}
* {{cite journal | vauthors = Runnels LW, Yue L, Clapham DE | title = The TRPM7 channel is inactivated by PIP(2) hydrolysis | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 329–36 | year = 2002 | pmid = 11941371 | doi = 10.1038/ncb781 }}
*{{cite journal | author=Tang Y, Tang J, Chen Z, ''et al.'' |title=Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37559-64 |year= 2001 |pmid= 10980202 |doi= 10.1074/jbc.M006635200 }}
* {{cite journal | vauthors = Scarlata S | title = Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts | journal = Biochemistry | volume = 41 | issue = 22 | pages = 7092–9 | year = 2002 | pmid = 12033943 | doi = 10.1021/bi025625j }}
*{{cite journal | author=Caricasole A, Sala C, Roncarati R, ''et al.'' |title=Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). |journal=Biochim. Biophys. Acta |volume=1517 |issue= 1 |pages= 63-72 |year= 2001 |pmid= 11118617 |doi= }}
* {{cite journal | vauthors = Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G, Capitani S | title = Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors | journal = J. Leukoc. Biol. | volume = 71 | issue = 6 | pages = 957–65 | year = 2002 | pmid = 12050180 | doi = }}
*{{cite journal | author=Singer AU, Waldo GL, Harden TK, Sondek J |title=A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. |journal=Nat. Struct. Biol. |volume=9 |issue= 1 |pages= 32-6 |year= 2002 |pmid= 11753430 |doi= 10.1038/nsb731 }}
* {{cite journal | vauthors = Barr AJ, Marjoram R, Xu J, Snyderman R | title = Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3 | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 1 | pages = 647–52 | year = 2002 | pmid = 12054652 | doi = 10.1016/S0006-291X(02)00259-0 }}
*{{cite journal | author=Runnels LW, Yue L, Clapham DE |title=The TRPM7 channel is inactivated by PIP(2) hydrolysis. |journal=Nat. Cell Biol. |volume=4 |issue= 5 |pages= 329-36 |year= 2002 |pmid= 11941371 |doi= 10.1038/ncb781 }}
* {{cite journal | vauthors = Buck E, Schatz P, Scarlata S, Iyengar R | title = Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2 | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49707–15 | year = 2002 | pmid = 12388553 | doi = 10.1074/jbc.M205553200 }}
*{{cite journal | author=Scarlata S |title=Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts. |journal=Biochemistry |volume=41 |issue= 22 |pages= 7092-9 |year= 2002 |pmid= 12033943 |doi= }}
* {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | year = 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 }}
*{{cite journal | author=Bertagnolo V, Marchisio M, Pierpaoli S, ''et al.'' |title=Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors. |journal=J. Leukoc. Biol. |volume=71 |issue= 6 |pages= 957-65 |year= 2002 |pmid= 12050180 |doi= }}
*{{cite journal | author=Barr AJ, Marjoram R, Xu J, Snyderman R |title=Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 647-52 |year= 2002 |pmid= 12054652 |doi= 10.1016/S0006-291X(02)00259-0 }}
*{{cite journal  | author=Buck E, Schatz P, Scarlata S, Iyengar R |title=Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49707-15 |year= 2003 |pmid= 12388553 |doi= 10.1074/jbc.M205553200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi=  }}
}}
{{refend}}
{{refend}}


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[[Category:EC 3.1.4]]

Latest revision as of 01:54, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.[1][2][3]

Function

The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB2 has been shown to interact with MAP2K3[4] and TRPM7.[5]

References

  1. ↑ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J. Biol. Chem. 267 (23): 16048–55. PMID 1644792.
  2. ↑ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 48–9. doi:10.1159/000015166. PMID 9925923.
  3. ↑ "Entrez Gene: PLCB2 phospholipase C, beta 2".
  4. ↑ Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652.
  5. ↑ Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371.

Further reading

  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
  • Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. Chem. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993.
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
  • Darè E, Kifor O, Brown EM, Weber G (1998). "Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor". J. Mol. Endocrinol. 21 (1): 7–17. doi:10.1677/jme.0.0210007. PMID 9723859.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
  • Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000). "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF". J. Biol. Chem. 275 (48): 37559–64. doi:10.1074/jbc.M006635200. PMID 10980202.
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617.
  • Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q". Nat. Struct. Biol. 9 (1): 32–6. doi:10.1038/nsb731. PMID 11753430.
  • Runnels LW, Yue L, Clapham DE (2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371.
  • Scarlata S (2002). "Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts". Biochemistry. 41 (22): 7092–9. doi:10.1021/bi025625j. PMID 12033943.
  • Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G, Capitani S (2002). "Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors". J. Leukoc. Biol. 71 (6): 957–65. PMID 12050180.
  • Barr AJ, Marjoram R, Xu J, Snyderman R (2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652.
  • Buck E, Schatz P, Scarlata S, Iyengar R (2002). "Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2". J. Biol. Chem. 277 (51): 49707–15. doi:10.1074/jbc.M205553200. PMID 12388553.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
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