FGF7: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
m Bot: HTTP→HTTPS (v470)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Keratinocyte growth factor''' is a [[protein]] that in humans is encoded by the ''FGF7'' [[gene]].<ref name="pmid7749227">{{cite journal | vauthors = Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I | title = Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively | journal = Mammalian Genome | volume = 6 | issue = 3 | pages = 196–7 | date = Mar 1995 | pmid = 7749227 | pmc =  | doi = 10.1007/BF00293012 }}</ref><ref name="pmid1409637">{{cite journal | vauthors = Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA | title = Emergence of the keratinocyte growth factor multigene family during the great ape radiation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 19 | pages = 9287–91 | date = Oct 1992 | pmid = 1409637 | pmc = 50111 | doi = 10.1073/pnas.89.19.9287 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FGF7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qqk.
| PDB = {{PDB2|1qqk}}
| Name = Fibroblast growth factor 7 (keratinocyte growth factor)
| HGNCid = 3685
| Symbol = FGF7
| AltSymbols =; HBGF-7; KGF
| OMIM = 148180
| ECnumber = 
| Homologene = 7316
| MGIid = 95521
| GeneAtlas_image1 = PBB_GE_FGF7_205782_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2252
    | Hs_Ensembl = ENSG00000140285
    | Hs_RefseqProtein = NP_002000
    | Hs_RefseqmRNA = NM_002009
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 47502751
    | Hs_GenLoc_end = 47566815
    | Hs_Uniprot = P21781
    | Mm_EntrezGene = 14178
    | Mm_Ensembl = ENSMUSG00000027208
    | Mm_RefseqmRNA = NM_008008
    | Mm_RefseqProtein = NP_032034
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 125726225
    | Mm_GenLoc_end = 125781969
    | Mm_Uniprot = Q544I6
  }}
}}
'''Fibroblast growth factor 7 (keratinocyte growth factor)''', also known as '''FGF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FGF7 has been shown to [[Protein-protein interaction|interact]] with [[Perlecan]].<ref name=pmid10702276>{{cite journal | vauthors = Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV | title = The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 10 | pages = 7095–100 | date = Mar 2000 | pmid = 10702276 | doi = 10.1074/jbc.275.10.7095 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S | title = Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair | journal = The Journal of Investigative Dermatology. Symposium Proceedings | volume = 5 | issue = 1 | pages = 34–9 | date = Dec 2000 | pmid = 11147673 | doi = 10.1046/j.1087-0024.2000.00009.x }}
| citations =
* {{cite journal | vauthors = Ware LB, Matthay MA | title = Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 282 | issue = 5 | pages = L924–40 | date = May 2002 | pmid = 11943656 | doi = 10.1152/ajplung.00439.2001 }}
*{{cite journal | author=Beer HD, Gassmann MG, Munz B, ''et al.'' |title=Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. |journal=J. Investig. Dermatol. Symp. Proc. |volume=5 |issue= 1 |pages= 34-9 |year= 2001 |pmid= 11147673 |doi= 10.1046/j.1087-0024.2000.00009.x }}
* {{cite journal | vauthors = Finch PW, Rubin JS | title = Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair | journal = Advances in Cancer Research | volume = 91 | issue =  | pages = 69–136 | year = 2004 | pmid = 15327889 | doi = 10.1016/S0065-230X(04)91003-2 | isbn = 978-0-12-006691-9 | series = Advances in Cancer Research }}
*{{cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924-40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001 }}
* {{cite journal | vauthors = Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA | title = Expression cloning of a human dual-specificity phosphatase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 24 | pages = 12170–4 | date = Dec 1992 | pmid = 1281549 | pmc = 50720 | doi = 10.1073/pnas.89.24.12170 }}
*{{cite journal | author=Finch PW, Rubin JS |title=Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. |journal=Adv. Cancer Res. |volume=91 |issue=  |pages= 69-136 |year= 2004 |pmid= 15327889 |doi= 10.1016/S0065-230X(04)91003-2 }}
* {{cite journal | vauthors = Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS | title = Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity | journal = Annals of the New York Academy of Sciences | volume = 638 | issue = | pages = 62–77 | year = 1992 | pmid = 1664700 | doi = 10.1111/j.1749-6632.1991.tb49018.x }}
*{{cite journal | author=Ishibashi T, Bottaro DP, Chan A, ''et al.'' |title=Expression cloning of a human dual-specificity phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 24 |pages= 12170-4 |year= 1993 |pmid= 1281549 |doi= }}
* {{cite journal | vauthors = Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA | title = Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth | journal = Science | volume = 245 | issue = 4919 | pages = 752–5 | date = Aug 1989 | pmid = 2475908 | doi = 10.1126/science.2475908 }}
*{{cite journal | author=Kelley MJ, Pech M, Seuanez HN, ''et al.'' |title=Emergence of the keratinocyte growth factor multigene family during the great ape radiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9287-91 |year= 1992 |pmid= 1409637 |doi= }}
* {{cite journal | vauthors = Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA | title = Purification and characterization of a newly identified growth factor specific for epithelial cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 3 | pages = 802–6 | date = Feb 1989 | pmid = 2915979 | pmc = 286565 | doi = 10.1073/pnas.86.3.802 }}
*{{cite journal | author=Aaronson SA, Bottaro DP, Miki T, ''et al.'' |title=Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. |journal=Ann. N. Y. Acad. Sci. |volume=638 |issue= |pages= 62-77 |year= 1992 |pmid= 1664700 |doi= }}
* {{cite journal | vauthors = Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR | title = Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor | journal = The Journal of Biological Chemistry | volume = 268 | issue = 8 | pages = 5388–94 | date = Mar 1993 | pmid = 7680645 | doi =  }}
*{{cite journal | author=Finch PW, Rubin JS, Miki T, ''et al.'' |title=Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. |journal=Science |volume=245 |issue= 4919 |pages= 752-5 |year= 1989 |pmid= 2475908 |doi= }}
* {{cite journal | vauthors = Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL | title = Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy | journal = Molecular and Cellular Biology | volume = 13 | issue = 8 | pages = 4513–22 | date = Aug 1993 | pmid = 7687739 | pmc = 360063 | doi =  }}
*{{cite journal | author=Rubin JS, Osada H, Finch PW, ''et al.'' |title=Purification and characterization of a newly identified growth factor specific for epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 3 |pages= 802-6 |year= 1989 |pmid= 2915979 |doi=  }}
* {{cite journal | vauthors = Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT | title = The function of KGF in morphogenesis of epithelium and reepithelialization of wounds | journal = Science | volume = 266 | issue = 5186 | pages = 819–22 | date = Nov 1994 | pmid = 7973639 | doi = 10.1126/science.7973639 }}
*{{cite journal | author=Ron D, Reich R, Chedid M, ''et al.'' |title=Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5388-94 |year= 1993 |pmid= 7680645 |doi=  }}
* {{cite journal | vauthors = Wilson SE, Walker JW, Chwang EL, He YG | title = Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea | journal = Investigative Ophthalmology & Visual Science | volume = 34 | issue = 8 | pages = 2544–61 | date = Jul 1993 | pmid = 8392040 | doi =  }}
*{{cite journal | author=Yan G, Fukabori Y, McBride G, ''et al.'' |title=Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4513-22 |year= 1993 |pmid= 7687739 |doi= }}
* {{cite journal | vauthors = Guo L, Degenstein L, Fuchs E | title = Keratinocyte growth factor is required for hair development but not for wound healing | journal = Genes & Development | volume = 10 | issue = 2 | pages = 165–75 | date = Jan 1996 | pmid = 8566750 | doi = 10.1101/gad.10.2.165 }}
*{{cite journal | author=Mattei MG, deLapeyrière O, Bresnick J, ''et al.'' |title=Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. |journal=Mamm. Genome |volume=6 |issue= 3 |pages= 196-7 |year= 1995 |pmid= 7749227 |doi=  }}
* {{cite journal | vauthors = Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M | title = Receptor specificity of the fibroblast growth factor family | journal = The Journal of Biological Chemistry | volume = 271 | issue = 25 | pages = 15292–7 | date = Jun 1996 | pmid = 8663044 | doi = 10.1074/jbc.271.25.15292 }}
*{{cite journal | author=Werner S, Smola H, Liao X, ''et al.'' |title=The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. |journal=Science |volume=266 |issue= 5186 |pages= 819-22 |year= 1994 |pmid= 7973639 |doi= }}
* {{cite journal | vauthors = Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK | title = Keratinocyte growth factor and its receptor are involved in regulating early lung branching | journal = Development | volume = 122 | issue = 10 | pages = 3107–15 | date = Oct 1996 | pmid = 8898224 | doi =  }}
*{{cite journal | author=Wilson SE, Walker JW, Chwang EL, He YG |title=Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. |journal=Invest. Ophthalmol. Vis. Sci. |volume=34 |issue= 8 |pages= 2544-61 |year= 1993 |pmid= 8392040 |doi= }}
* {{cite journal | vauthors = Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC | title = Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11461–5 | date = Oct 1997 | pmid = 9326632 | pmc = 23506 | doi = 10.1073/pnas.94.21.11461 }}
*{{cite journal | author=Guo L, Degenstein L, Fuchs E |title=Keratinocyte growth factor is required for hair development but not for wound healing. |journal=Genes Dev. |volume=10 |issue= 2 |pages= 165-75 |year= 1996 |pmid= 8566750 |doi=  }}
* {{cite journal | vauthors = Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS | title = Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries | journal = Journal of Cellular Physiology | volume = 173 | issue = 3 | pages = 380–6 | date = Dec 1997 | pmid = 9369951 | doi = 10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G }}
*{{cite journal | author=Ornitz DM, Xu J, Colvin JS, ''et al.'' |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292-7 |year= 1996 |pmid= 8663044 |doi= }}
* {{cite journal | vauthors = Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K | title = Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps | journal = The Annals of Otology, Rhinology, and Laryngology | volume = 107 | issue = 10 Pt 1 | pages = 885–90 | date = Oct 1998 | pmid = 9794620 | doi =  }}
*{{cite journal | author=Post M, Souza P, Liu J, ''et al.'' |title=Keratinocyte growth factor and its receptor are involved in regulating early lung branching. |journal=Development |volume=122 |issue= 10 |pages= 3107-15 |year= 1996 |pmid= 8898224 |doi= }}
* {{cite journal | vauthors = Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV | title = The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 10 | pages = 7095–100 | date = Mar 2000 | pmid = 10702276 | doi = 10.1074/jbc.275.10.7095 }}
*{{cite journal  | author=Zimonjic DB, Kelley MJ, Rubin JS, ''et al.'' |title=Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11461-5 |year= 1997 |pmid= 9326632 |doi=  }}
*{{cite journal | author=Winkles JA, Alberts GF, Chedid M, ''et al.'' |title=Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. |journal=J. Cell. Physiol. |volume=173 |issue= 3 |pages= 380-6 |year= 1997 |pmid= 9369951 |doi= 10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G }}
*{{cite journal  | author=Ishibashi T, Tanaka T, Nibu K, ''et al.'' |title=Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps. |journal=Ann. Otol. Rhinol. Laryngol. |volume=107 |issue= 10 Pt 1 |pages= 885-90 |year= 1998 |pmid= 9794620 |doi=  }}
*{{cite journal  | author=Mongiat M, Taylor K, Otto J, ''et al.'' |title=The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7095-100 |year= 2000 |pmid= 10702276 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=2252}}
{{WikiDoc Sources}}
{{Growth factors}}
{{Growth factor receptor modulators}}
 
 
{{gene-15-stub}}

Latest revision as of 01:40, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.[3]

Interactions

FGF7 has been shown to interact with Perlecan.[4]

References

  1. ↑ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227.
  2. ↑ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.
  3. ↑ 3.0 3.1 "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
  4. ↑ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=FGF7&oldid=1416878"