CCNDBP1: Difference between revisions

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{{Infobox_gene}}
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'''Cyclin-D1-binding protein 1''' is a [[protein]] that in humans is encoded by the ''CCNDBP1'' [[gene]].<ref name="pmid10801854">{{cite journal | vauthors = Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M | title = GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity | journal = J Biol Chem | volume = 275 | issue = 27 | pages = 20942–8 |date=Aug 2000 | pmid = 10801854 | pmc = | doi = 10.1074/jbc.M002598200 }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cyclin D-type binding-protein 1
| HGNCid = 1587
| Symbol = CCNDBP1
| AltSymbols =; DIP1; GCIP
| OMIM = 607089
| ECnumber = 
| Homologene = 7826
| MGIid = 109595
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23582
    | Hs_Ensembl = ENSG00000166946
    | Hs_RefseqProtein = NP_036274
    | Hs_RefseqmRNA = NM_012142
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 41264793
    | Hs_GenLoc_end = 41274680
    | Hs_Uniprot = 
    | Mm_EntrezGene = 17151
    | Mm_Ensembl = ENSMUSG00000023572
    | Mm_RefseqmRNA = NM_010761
    | Mm_RefseqProtein = NP_034891
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 120699913
    | Mm_GenLoc_end = 120708332
    | Mm_Uniprot = 
  }}
}}
'''Cyclin D-type binding-protein 1''', also known as '''CCNDBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23582| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene was identified by the interaction of its gene product with Grap2, a [[leukocyte]]-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific [[gene expression]]. Two alternatively spliced variants, which encode distinct isoforms, have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23582| accessdate = }}</ref>
| summary_text = This gene was identified by the interaction of its gene product with Grap2, a [[leukocyte]]-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific [[gene expression]]. Two alternatively spliced variants, which encode distinct isoforms, have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23582| accessdate = }}</ref>
}}
}}
==Interactions==
CCNDBP1 has been shown to [[Protein-protein interaction|interact]] with [[GRAP2]]<ref name=autogenerated1>{{cite journal |last=Xia |first=C |author2=Bao Z|author3=Tabassam F|author4=Ma W|author5=Qiu M|author6=Hua S|author7=Liu M |date=Jul 2000 |title=GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity |journal=J. Biol. Chem. |volume=275 |issue=27 |pages=20942–8 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10801854 |doi = 10.1074/jbc.M002598200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Cyclin D1]].<ref name=pmid10801854/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ma W, Xia X, Stafford LJ, ''et al.'' |title=Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. |journal=Oncogene |volume=25 |issue= 30 |pages= 4207-16 |year= 2006 |pmid= 16501603 |doi= 10.1038/sj.onc.1209450 }}
*{{cite journal  | vauthors=Ma W, Xia X, Stafford LJ |title=Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. |journal=Oncogene |volume=25 |issue= 30 |pages= 4207–16 |year= 2006 |pmid= 16501603 |doi= 10.1038/sj.onc.1209450 |display-authors=etal}}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Chang MS, Chen CY, Yeh HI, ''et al.'' |title=Cloning, expression, and genomic organization of mouse mp29 gene. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 2 |pages= 241-6 |year= 2003 |pmid= 12437976 |doi=  }}
*{{cite journal  | vauthors=Chang MS, Chen CY, Yeh HI |title=Cloning, expression, and genomic organization of mouse mp29 gene |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 2 |pages= 241–6 |year= 2003 |pmid= 12437976 |doi=10.1016/S0006-291X(02)02605-0 |display-authors=etal}}
*{{cite journal  | author=Dgany O, Avidan N, Delaunay J, ''et al.'' |title=Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1467-74 |year= 2003 |pmid= 12434312 |doi=  }}
*{{cite journal  | vauthors=Dgany O, Avidan N, Delaunay J |title=Congenital Dyserythropoietic Anemia Type I Is Caused by Mutations in Codanin-1 |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1467–74 |year= 2003 |pmid= 12434312 |doi=10.1086/344781  | pmc=378595 |display-authors=etal}}
*{{cite journal  | author=Terai S, Aoki H, Ashida K, Thorgeirsson SS |title=Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression. |journal=Hepatology |volume=32 |issue= 2 |pages= 357-66 |year= 2000 |pmid= 10915743 |doi= 10.1053/jhep.2000.9092 }}
*{{cite journal  | vauthors=Terai S, Aoki H, Ashida K, Thorgeirsson SS |title=Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression |journal=Hepatology |volume=32 |issue= 2 |pages= 357–66 |year= 2000 |pmid= 10915743 |doi= 10.1053/jhep.2000.9092 }}
*{{cite journal  | author=Yamada S, Iida T, Tabata T, ''et al.'' |title=Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat. |journal=Hepatology |volume=32 |issue= 2 |pages= 278-88 |year= 2000 |pmid= 10915734 |doi= 10.1053/jhep.2000.9604 }}
*{{cite journal  | vauthors=Yamada S, Iida T, Tabata T |title=Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat |journal=Hepatology |volume=32 |issue= 2 |pages= 278–88 |year= 2000 |pmid= 10915734 |doi= 10.1053/jhep.2000.9604 |display-authors=etal}}
*{{cite journal  | author=Yao Y, Doki Y, Jiang W, ''et al.'' |title=Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins. |journal=Exp. Cell Res. |volume=257 |issue= 1 |pages= 22-32 |year= 2000 |pmid= 10854051 |doi= 10.1006/excr.2000.4884 }}
*{{cite journal  | vauthors=Yao Y, Doki Y, Jiang W |title=Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins |journal=Exp. Cell Res. |volume=257 |issue= 1 |pages= 22–32 |year= 2000 |pmid= 10854051 |doi= 10.1006/excr.2000.4884 |display-authors=etal}}
*{{cite journal  | author=Xia C, Bao Z, Tabassam F, ''et al.'' |title=GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20942-8 |year= 2000 |pmid= 10801854 |doi= 10.1074/jbc.M002598200 }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CCNDBP1}}
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Revision as of 09:18, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.[1][2]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.[2]

Interactions

CCNDBP1 has been shown to interact with GRAP2[3] and Cyclin D1.[1]

References

  1. ↑ 1.0 1.1 Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
  2. ↑ 2.0 2.1 "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1".
  3. ↑ Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. UNITED STATES. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN 0021-9258. PMID 10801854.

Further reading

External links


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