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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''BCL2/adenovirus E1B 19 kDa protein-interacting protein 2''' is a [[protein]] that in humans is encoded by the ''BNIP2'' [[gene]].<ref name="pmid7954800">{{cite journal | vauthors = Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G | title = Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins | journal = Cell | volume = 79 | issue = 2 | pages = 341–51 |date=November 1994 | pmid = 7954800 | pmc =  | doi =10.1016/0092-8674(94)90202-X  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=663| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2/adenovirus E1B 19kDa interacting protein 2
| HGNCid = 1083
| Symbol = BNIP2
| AltSymbols =; BNIP-2; NIP2
| OMIM = 603292
| ECnumber = 
| Homologene = 3194
| MGIid = 109327
| GeneAtlas_image1 = PBB_GE_BNIP2_209308_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0043231 |text = intracellular membrane-bound organelle}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 663
    | Hs_Ensembl = ENSG00000140299
    | Hs_RefseqProtein = NP_004321
    | Hs_RefseqmRNA = NM_004330
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 57742356
    | Hs_GenLoc_end = 57768810
    | Hs_Uniprot = Q12982
    | Mm_EntrezGene = 12175
    | Mm_Ensembl = ENSMUSG00000011958
    | Mm_RefseqmRNA = NM_001008238
    | Mm_RefseqProtein = NP_001008239
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 69788665
    | Mm_GenLoc_end = 69807481
    | Mm_Uniprot = Q8K4H0
  }}
}}
'''BCL2/adenovirus E1B 19kDa interacting protein 2''', also known as '''BNIP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=663| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[Bcl-2 family|BCL2]]/adenovirus E1B 19 kd-interacting protein (BNIP) family.  Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of [[BCL-2]], also an [[apoptotic]] protector.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family.  Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.<ref name="entrez">{{cite web | title = Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=663| accessdate = }}</ref>
BNIP2 has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[ARHGAP1]],<ref name = pmid10954711/><ref name = pmid10551883/>
* [[Bcl-2]],<ref name = "pmid7954800"/><ref name = pmid12901880>{{cite journal | date = August 2003 | vauthors = Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J | title = BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 308 | issue = 2 | pages = 379–85  | pmid = 12901880 | doi = 10.1016/s0006-291x(03)01387-1}}</ref> and
* [[CDC42]].<ref name = pmid10954711>{{cite journal | date = December 2000 | vauthors = Low BC, Seow KT, Guy GR | title = The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37742–51  | pmid = 10954711 | doi = 10.1074/jbc.M004897200}}</ref><ref name = pmid10551883>{{cite journal | date = November 1999 | vauthors = Low BC, Lim YP, Lim J, Wong ES, Guy GR | title = Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42 | journal = J. Biol. Chem. | volume = 274 | issue = 46 | pages = 33123–30  | pmid = 10551883 | doi = 10.1074/jbc.274.46.33123}}</ref><ref name = pmid10799524>{{cite journal | date = May 2000 | vauthors = Low BC, Seow KT, Guy GR | title = Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2 | journal = J. Biol. Chem. | volume = 275 | issue = 19 | pages = 14415–22  | pmid = 10799524 | doi = 10.1074/jbc.275.19.14415}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BNIP2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Belcredito S, Vegeto E, Brusadelli A |title=Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2 |journal=Brain Res. Brain Res. Rev. |volume=37 |issue= 1–3 |pages= 335–42 |year= 2002 |pmid= 11744098 |doi=10.1016/S0165-0173(01)00138-2 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Ohi N, Tokunaga A, Tsunoda H |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 |display-authors=etal}}
*{{cite journal  | author=Belcredito S, Vegeto E, Brusadelli A, ''et al.'' |title=Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2. |journal=Brain Res. Brain Res. Rev. |volume=37 |issue= 1-3 |pages= 335-42 |year= 2002 |pmid= 11744098 |doi= }}
*{{cite journal  | vauthors=Zhou YT, Soh UJ, Shang X |title=The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7483–92 |year= 2002 |pmid= 11741952 |doi= 10.1074/jbc.M109459200 |display-authors=etal}}
*{{cite journal  | author=Boyd JM, Malstrom S, Subramanian T, ''et al.'' |title=Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. |journal=Cell |volume=79 |issue= 2 |pages= 341-51 |year= 1994 |pmid= 7954800 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Ohi N, Tokunaga A, Tsunoda H, ''et al.'' |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314-25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 }}
*{{cite journal  | vauthors=Shang X, Zhou YT, Low BC |title=Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1 |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45903–14 |year= 2003 |pmid= 12944407 |doi= 10.1074/jbc.M304514200 }}
*{{cite journal  | author=Low BC, Lim YP, Lim J, ''et al.'' |title=Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 33123-30 |year= 2000 |pmid= 10551883 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Low BC, Seow KT, Guy GR |title=Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14415-22 |year= 2000 |pmid= 10799524 |doi=  }}
*{{cite journal  | vauthors=Zhou YT, Guy GR, Low BC |title=BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 263–74 |year= 2005 |pmid= 15652341 |doi= 10.1016/j.yexcr.2004.08.044 }}
*{{cite journal  | author=Low BC, Seow KT, Guy GR |title=The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37742-51 |year= 2001 |pmid= 10954711 |doi= 10.1074/jbc.M004897200 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Zhou YT, Soh UJ, Shang X, ''et al.'' |title=The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7483-92 |year= 2002 |pmid= 11741952 |doi= 10.1074/jbc.M109459200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Qin W, Hu J, Guo M, ''et al.'' |title=BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 379-85 |year= 2003 |pmid= 12901880 |doi=  }}
*{{cite journal  | author=Shang X, Zhou YT, Low BC |title=Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45903-14 |year= 2003 |pmid= 12944407 |doi= 10.1074/jbc.M304514200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhou YT, Guy GR, Low BC |title=BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 263-74 |year= 2005 |pmid= 15652341 |doi= 10.1016/j.yexcr.2004.08.044 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:38, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.[1][2]

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector.[2]

Interactions

BNIP2 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800.
  2. ↑ 2.0 2.1 "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2".
  3. ↑ 3.0 3.1 Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. doi:10.1074/jbc.M004897200. PMID 10954711.
  4. ↑ 4.0 4.1 Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. doi:10.1074/jbc.274.46.33123. PMID 10551883.
  5. ↑ Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
  6. ↑ Low BC, Seow KT, Guy GR (May 2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19): 14415–22. doi:10.1074/jbc.275.19.14415. PMID 10799524.

External links

Further reading


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