SULT1A2: Difference between revisions

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Latest revision as of 02:08, 27 October 2017

Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.^[1]^[2]^[3]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.^[3]

References

↑ Her C, Raftogianis R, Weinshilboum RM (Sep 1996). "Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization". Genomics. 33 (3): 409–20. doi:10.1006/geno.1996.0216. PMID 8661000.
↑ Dooley TP, Huang Z (Dec 1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16". Biochem Biophys Res Commun. 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648.
↑ ^3.0 ^3.1 "Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2".

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. PMID 9034160.
Windmill KF, Christiansen A, Teusner JT, et al. (1998). "Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry". Chem. Biol. Interact. 109 (1–3): 341–6. doi:10.1016/S0009-2797(97)00144-0. PMID 9566757.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112-113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
Ozawa S, Nagata K, Shimada M, et al. (1995). "Primary structures and properties of two related forms of aryl sulfotransferases in human liver". Pharmacogenetics. 5 Spec No: S135–40. doi:10.1097/00008571-199512001-00015. PMID 7581483.
Yamazoe Y, Ozawa S, Nagata K, et al. (1995). "Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds". Environ. Health Perspect. 102 Suppl 6: 99–103. doi:10.1289/ehp.94102s699. PMC 1566861. PMID 7889867.
Yamazoe Y, Nagata K, Ozawa S, Kato R (1994). "Structural similarity and diversity of sulfotransferases". Chem. Biol. Interact. 92 (1–3): 107–17. doi:10.1016/0009-2797(94)90057-4. PMID 8033246.
Zhu X, Veronese ME, Iocco P, McManus ME (1996). "cDNA cloning and expression of a new form of human aryl sulfotransferase". Int. J. Biochem. Cell Biol. 28 (5): 565–71. doi:10.1016/1357-2725(95)00164-6. PMID 8697101.
Gaedigk A, Beatty BG, Grant DM (1997). "Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene". Genomics. 40 (2): 242–6. doi:10.1006/geno.1996.4575. PMID 9119390.
Harris RM, Waring RH, Kirk CJ, Hughes PJ (2000). "Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases". J. Biol. Chem. 275 (1): 159–66. doi:10.1074/jbc.275.1.159. PMID 10617600.
Engelke CE, Meinl W, Boeing H, Glatt H (2000). "Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2". Pharmacogenetics. 10 (2): 163–9. doi:10.1097/00008571-200003000-00008. PMID 10762004.
Carlini EJ, Raftogianis RB, Wood TC, et al. (2001). "Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects". Pharmacogenetics. 11 (1): 57–68. doi:10.1097/00008571-200102000-00007. PMID 11207031.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[pmid8661000-1] Her C, Raftogianis R, Weinshilboum RM (Sep 1996). "Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization". Genomics. 33 (3): 409–20. doi:10.1006/geno.1996.0216. PMID 8661000.

[pmid8912648-2] Dooley TP, Huang Z (Dec 1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16". Biochem Biophys Res Commun. 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
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+'''Sulfotransferase 1A2''' is an [[enzyme]] that in humans is encoded by the ''SULT1A2'' [[gene]].<ref name="pmid8661000">{{cite journal | vauthors = Her C, Raftogianis R, Weinshilboum RM | title = Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization | journal = Genomics | volume = 33 | issue = 3 | pages = 409–20 |date=Sep 1996 | pmid = 8661000 | pmc =  | doi = 10.1006/geno.1996.0216 }}</ref><ref name="pmid8912648">{{cite journal | vauthors = Dooley TP, Huang Z | title = Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16 | journal = Biochem Biophys Res Commun | volume = 228 | issue = 1 | pages = 134–40 |date=Dec 1996 | pmid = 8912648 | pmc =  | doi = 10.1006/bbrc.1996.1628 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6799| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_SULT1A2_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cjm.
- | PDB = {{PDB2|1cjm}}, {{PDB2|1ls6}}, {{PDB2|1z28}}, {{PDB2|1z29}}, {{PDB2|2a3r}}, {{PDB2|2d06}}
- | Name = Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
- | HGNCid = 11454
- | Symbol = SULT1A2
- | AltSymbols =; HAST4; MGC142287; MGC142289; P-PST; ST1A2; STP2; TSPST2
- | OMIM = 601292
- | ECnumber =
- | Homologene = 88641
- | MGIid =
-  | GeneAtlas_image1 = PBB_GE_SULT1A2_203615_x_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SULT1A2_207122_x_at_tn.png
- | GeneAtlas_image3 = PBB_GE_SULT1A2_209607_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0004062 |text = aryl sulfotransferase activity}} {{GNF_GO|id=GO:0008146 |text = sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006584 |text = catecholamine metabolic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0009309 |text = amine biosynthetic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6799
-    | Hs_Ensembl = ENSG00000197165
-    | Hs_RefseqProtein = NP_001045
-    | Hs_RefseqmRNA = NM_001054
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 28510850
-    | Hs_GenLoc_end = 28514752
-    | Hs_Uniprot = P50226
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2''', also known as '''SULT1A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6799| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6799| accessdate = }}</ref>
+| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi=  }}
+*{{cite journal   |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi=  }}
-*{{cite journal  | author=Windmill KF, Christiansen A, Teusner JT, ''et al.'' |title=Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry. |journal=Chem. Biol. Interact. |volume=109 |issue= 1-3 |pages= 341-6 |year= 1998 |pmid= 9566757 |doi=  }}
+*{{cite journal   |vauthors=Windmill KF, Christiansen A, Teusner JT, etal |title=Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry. |journal=Chem. Biol. Interact. |volume=109 |issue= 1–3 |pages= 341–6 |year= 1998 |pmid= 9566757 |doi=10.1016/S0009-2797(97)00144-0  }}
-*{{cite journal  | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341-8 |year= 2000 |pmid= 10720750 |doi=  }}
+*{{cite journal   |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3  }}
-*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi=  }}
+*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics |journal=Chem. Biol. Interact. |volume=129 |issue= 1–2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7  }}
-*{{cite journal  | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi=  }}
+*{{cite journal   |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects |journal=Mutat. Res. |volume=482 |issue= 1–2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=  10.1016/S0027-5107(01)00207-X}}
-*{{cite journal  | author=Ozawa S, Nagata K, Shimada M, ''et al.'' |title=Primary structures and properties of two related forms of aryl sulfotransferases in human liver. |journal=Pharmacogenetics |volume=5 Spec No |issue=  |pages= S135-40 |year= 1995 |pmid= 7581483 |doi=  }}
+*{{cite journal   |vauthors=Ozawa S, Nagata K, Shimada M, etal |title=Primary structures and properties of two related forms of aryl sulfotransferases in human liver |journal=Pharmacogenetics |volume=5 Spec No |issue=  |pages= S135–40 |year= 1995 |pmid= 7581483 |doi=10.1097/00008571-199512001-00015  }}
-*{{cite journal  | author=Yamazoe Y, Ozawa S, Nagata K, ''et al.'' |title=Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds. |journal=Environ. Health Perspect. |volume=102 Suppl 6 |issue=  |pages= 99-103 |year= 1995 |pmid= 7889867 |doi=  }}
+*{{cite journal   |vauthors=Yamazoe Y, Ozawa S, Nagata K, etal |title=Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds |journal=Environ. Health Perspect. |volume=102 Suppl 6 |issue=  |pages= 99–103 |year= 1995 |pmid= 7889867 |doi=  10.1289/ehp.94102s699| pmc=1566861  }}
-*{{cite journal  | author=Yamazoe Y, Nagata K, Ozawa S, Kato R |title=Structural similarity and diversity of sulfotransferases. |journal=Chem. Biol. Interact. |volume=92 |issue= 1-3 |pages= 107-17 |year= 1994 |pmid= 8033246 |doi=  }}
+*{{cite journal  | vauthors=Yamazoe Y, Nagata K, Ozawa S, Kato R |title=Structural similarity and diversity of sulfotransferases |journal=Chem. Biol. Interact. |volume=92 |issue= 1–3 |pages= 107–17 |year= 1994 |pmid= 8033246 |doi=10.1016/0009-2797(94)90057-4  }}
-*{{cite journal  | author=Her C, Raftogianis R, Weinshilboum RM |title=Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. |journal=Genomics |volume=33 |issue= 3 |pages= 409-20 |year= 1996 |pmid= 8661000 |doi= 10.1006/geno.1996.0216 }}
+*{{cite journal  | vauthors=Zhu X, Veronese ME, Iocco P, McManus ME |title=cDNA cloning and expression of a new form of human aryl sulfotransferase |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 5 |pages= 565–71 |year= 1996 |pmid= 8697101 |doi=10.1016/1357-2725(95)00164-6  }}
-*{{cite journal  | author=Zhu X, Veronese ME, Iocco P, McManus ME |title=cDNA cloning and expression of a new form of human aryl sulfotransferase. |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 5 |pages= 565-71 |year= 1996 |pmid= 8697101 |doi=  }}
+*{{cite journal  | vauthors=Gaedigk A, Beatty BG, Grant DM |title=Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene |journal=Genomics |volume=40 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9119390 |doi= 10.1006/geno.1996.4575 }}
-*{{cite journal  | author=Dooley TP, Huang Z |title=Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 1 |pages= 134-40 |year= 1996 |pmid= 8912648 |doi= 10.1006/bbrc.1996.1628 }}
+*{{cite journal  | vauthors=Harris RM, Waring RH, Kirk CJ, Hughes PJ |title=Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 159–66 |year= 2000 |pmid= 10617600 |doi=10.1074/jbc.275.1.159  }}
-*{{cite journal  | author=Gaedigk A, Beatty BG, Grant DM |title=Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. |journal=Genomics |volume=40 |issue= 2 |pages= 242-6 |year= 1997 |pmid= 9119390 |doi= 10.1006/geno.1996.4575 }}
+*{{cite journal  | vauthors=Engelke CE, Meinl W, Boeing H, Glatt H |title=Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2 |journal=Pharmacogenetics |volume=10 |issue= 2 |pages= 163–9 |year= 2000 |pmid= 10762004 |doi=10.1097/00008571-200003000-00008  }}
-*{{cite journal  | author=Harris RM, Waring RH, Kirk CJ, Hughes PJ |title=Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 159-66 |year= 2000 |pmid= 10617600 |doi=  }}
+*{{cite journal   |vauthors=Carlini EJ, Raftogianis RB, Wood TC, etal |title=Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects |journal=Pharmacogenetics |volume=11 |issue= 1 |pages= 57–68 |year= 2001 |pmid= 11207031 |doi=10.1097/00008571-200102000-00007  }}
-*{{cite journal  | author=Engelke CE, Meinl W, Boeing H, Glatt H |title=Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. |journal=Pharmacogenetics |volume=10 |issue= 2 |pages= 163-9 |year= 2000 |pmid= 10762004 |doi=  }}
-*{{cite journal  | author=Carlini EJ, Raftogianis RB, Wood TC, ''et al.'' |title=Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. |journal=Pharmacogenetics |volume=11 |issue= 1 |pages= 57-68 |year= 2001 |pmid= 11207031 |doi=  }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=6799}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
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-{{WikiDoc Sources}}

SULT1A2: Difference between revisions

Latest revision as of 02:08, 27 October 2017

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