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{{Infobox_gene}}
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'''Olfactory receptor 1E1''' is a [[protein]] that in humans is encoded by the ''OR1E1'' [[gene]].<ref name="pmid8004088">{{cite journal | vauthors = Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H| title = Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire | journal = Hum Mol Genet | volume = 3 | issue = 2 | pages = 229–35 |date=Jul 1994 | pmid = 8004088 | pmc =  | doi =10.1093/hmg/3.2.229 |display-authors=etal}}</ref><ref name="pmid1370859">{{cite journal | vauthors = Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J| title = Expression of members of the putative olfactory receptor gene family in mammalian germ cells | journal = Nature | volume = 355 | issue = 6359 | pages = 453–5 |date=Mar 1992 | pmid = 1370859 | pmc = | doi = 10.1038/355453a0 |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 1, subfamily E, member 1
| HGNCid = 8189
| Symbol = OR1E1
| AltSymbols =; OR17-2; HGM071; OR13-66; OR17-32; OR1E5; OR1E6; OR1E8P; OR1E9P; OST547
| OMIM =
| ECnumber =
| Homologene = 73918
| MGIid = 109315
  | GeneAtlas_image1 = PBB_GE_OR1E1_208587_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR1E1_214515_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8387
    | Hs_Ensembl = ENSG00000180016
    | Hs_RefseqProtein = NP_003544
    | Hs_RefseqmRNA = NM_003553
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3247510
    | Hs_GenLoc_end = 3248454
    | Hs_Uniprot = P30953
    | Mm_EntrezGene = 258925
    | Mm_Ensembl = ENSMUSG00000062128
    | Mm_RefseqmRNA = NM_146923
    | Mm_RefseqProtein = NP_667134
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 73169950
    | Mm_GenLoc_end = 73170894
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 1, subfamily E, member 1''', also known as '''OR1E1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8387| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal   |vauthors=Rouquier S, Taviaux S, Trask BJ, etal |title=Distribution of olfactory receptor genes in the human genome |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243–50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal  | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi=  }}
*{{cite journal   |vauthors=Glusman G, Sosinsky A, Ben-Asher E, etal |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster |journal=Genomics |volume=63 |issue= 2 |pages= 227–45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal  | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal  | vauthors=Rouquier S, Blancher A, Giorgi D |title=The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2870–4 |year= 2000 |pmid= 10706615 |doi= 10.1073/pnas.040580197 | pmc=16022 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 }}
*{{cite journal  | author=Rouquier S, Blancher A, Giorgi D |title=The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2870-4 |year= 2000 |pmid= 10706615 |doi= 10.1073/pnas.040580197 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]
 
 
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Latest revision as of 02:32, 27 October 2017

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SpeciesHumanMouse
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Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
  2. ↑ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
  3. ↑ 3.0 3.1 "Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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