Small nuclear ribonucleoprotein polypeptide A: Difference between revisions

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Revision as of 00:03, 12 September 2017

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.^[1]^[2]

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.^[3]

References

↑ Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A, et al. (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenet Cell Genet. 54 (1–2): 15–9. doi:10.1159/000132946. PMID 1701111.
↑ "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".
↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Hoffman DW, Query CC, Golden BL, et al. (1991). "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (6): 2495–9. doi:10.1073/pnas.88.6.2495. PMC 51259. PMID 1826055.
Nelissen RL, Sillekens PT, Beijer RP, et al. (1991). "Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein". Gene. 102 (2): 189–96. doi:10.1016/0378-1119(91)90077-O. PMID 1831431.
Jessen TH, Oubridge C, Teo CH, et al. (1991). "Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA". EMBO J. 10 (11): 3447–56. PMC 453073. PMID 1833186.
Nagai K, Oubridge C, Jessen TH, et al. (1991). "Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.". Nature. 348 (6301): 515–20. doi:10.1038/348515a0. PMID 2147232.
Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ (1988). "cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins". EMBO J. 6 (12): 3841–8. PMC 553857. PMID 2962859.
Oubridge C, Ito N, Evans PR, et al. (1994). "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin". Nature. 372 (6505): 432–8. doi:10.1038/372432a0. PMID 7984237.
Howe PW, Nagai K, Neuhaus D, Varani G (1994). "NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein". EMBO J. 13 (16): 3873–81. PMC 395300. PMID 8070414.
Allain FH, Gubser CC, Howe PW, et al. (1996). "Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation". Nature. 380 (6575): 646–50. doi:10.1038/380646a0. PMID 8602269.
Avis JM, Allain FH, Howe PW, et al. (1996). "Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding". J. Mol. Biol. 257 (2): 398–411. doi:10.1006/jmbi.1996.0171. PMID 8609632.
Lu J, Hall KB (1997). "Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy". Biochemistry. 36 (34): 10393–405. doi:10.1021/bi9709811. PMID 9265619.
Allain FH, Howe PW, Neuhaus D, Varani G (1997). "Structural basis of the RNA-binding specificity of human U1A protein". EMBO J. 16 (18): 5764–72. doi:10.1093/emboj/16.18.5764. PMC 1170207. PMID 9312034.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Ferré-D'Amaré AR, Zhou K, Doudna JA (1998). "Crystal structure of a hepatitis delta virus ribozyme". Nature. 395 (6702): 567–74. doi:10.1038/26912. PMID 9783582.
Lutz CS, Cooke C, O'Connor JP, et al. (1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
Hetzer M, Mattaj IW (2000). "An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins". J. Cell Biol. 148 (2): 293–303. doi:10.1083/jcb.148.2.293. PMC 2174293. PMID 10648562.
Klein Gunnewiek JM, Hussein RI, van Aarssen Y, et al. (2000). "Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation". Mol. Cell. Biol. 20 (6): 2209–17. doi:10.1128/MCB.20.6.2209-2217.2000. PMC 110837. PMID 10688667.
Varani L, Gunderson SI, Mattaj IW, et al. (2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nat. Struct. Biol. 7 (4): 329–35. doi:10.1038/74101. PMID 10742179.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi:10.1016/S1074-7613(01)00158-3. PMID 11420046.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid1701111-1] Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A, et al. (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenet Cell Genet. 54 (1–2): 15–9. doi:10.1159/000132946. PMID 1701111.

[entrez-2] "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".

[pmid11101529-3] Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

[1]

[2]

[3]

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+{{Infobox_gene}}
-{{PBB_Controls
+'''U1 small nuclear ribonucleoprotein A''' is a [[protein]] that in humans is encoded by the ''SNRPA'' [[gene]].<ref name="pmid1701111">{{cite journal  |vauthors=Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A, etal | title = Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region | journal = Cytogenet Cell Genet | volume = 54 | issue = 1-2 | pages = 15–9 |date=January 1991 | pmid = 1701111 | pmc =  | doi =10.1159/000132946  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6626| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_SNRPA_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aud.
- | PDB = {{PDB2|1aud}}, {{PDB2|1cx0}}, {{PDB2|1drz}}, {{PDB2|1dz5}}, {{PDB2|1fht}}, {{PDB2|1m5k}}, {{PDB2|1m5o}}, {{PDB2|1m5p}}, {{PDB2|1m5v}}, {{PDB2|1nu4}}, {{PDB2|1oia}}, {{PDB2|1sj3}}, {{PDB2|1sj4}}, {{PDB2|1sjf}}, {{PDB2|1u6b}}, {{PDB2|1urn}}, {{PDB2|1vbx}}, {{PDB2|1vby}}, {{PDB2|1vbz}}, {{PDB2|1vc0}}, {{PDB2|1vc5}}, {{PDB2|1vc6}}, {{PDB2|1vc7}}, {{PDB2|1zzn}}, {{PDB2|2nz4}}, {{PDB2|2oih}}, {{PDB2|2oj3}}, {{PDB2|2u1a}}
- | Name = Small nuclear ribonucleoprotein polypeptide A
- | HGNCid = 11151
- | Symbol = SNRPA
- | AltSymbols =; U1A
- | OMIM = 182285
- | ECnumber =
- | Homologene = 3380
- | MGIid = 1855690
-  | GeneAtlas_image1 = PBB_GE_SNRPA_201770_at_tn.png
-  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005685 |text = snRNP U1}}
- | Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6626
-    | Hs_Ensembl = ENSG00000077312
-    | Hs_RefseqProtein = NP_004587
-    | Hs_RefseqmRNA = NM_004596
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 45948619
-    | Hs_GenLoc_end = 45963130
-    | Hs_Uniprot = P09012
-    | Mm_EntrezGene = 53607
-    | Mm_Ensembl = ENSMUSG00000061479
-    | Mm_RefseqmRNA = NM_001046637
-    | Mm_RefseqProtein = NP_001040102
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 26895767
-    | Mm_GenLoc_end = 26905005
-    | Mm_Uniprot = Q62189
-  }}
-}}
-'''Small nuclear ribonucleoprotein polypeptide A''', also known as '''SNRPA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6626| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 53: / Line 7: @@
 | summary_text =
 }}
+==Interactions==
+Small nuclear ribonucleoprotein polypeptide A has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]].<ref name=pmid11101529>{{cite journal |last=Ajuh |first=P |authorlink= |author2=Kuster B |author3=Panov K |author4=Zomerdijk J C |author5=Mann M |author6=Lamond A I  |date=December 2000  |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Schonk D, van Dijk P, Riegmann P, ''et al.'' |title=Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1-2 |pages= 15-9 |year= 1991 |pmid= 1701111 |doi=  }}
+*{{cite journal   |vauthors=Hoffman DW, Query CC, Golden BL, etal |title=RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 6 |pages= 2495–9 |year= 1991 |pmid= 1826055 |doi=10.1073/pnas.88.6.2495  | pmc=51259  }}
-*{{cite journal  | author=Hoffman DW, Query CC, Golden BL, ''et al.'' |title=RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 6 |pages= 2495-9 |year= 1991 |pmid= 1826055 |doi=  }}
+*{{cite journal   |vauthors=Nelissen RL, Sillekens PT, Beijer RP, etal |title=Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. |journal=Gene |volume=102 |issue= 2 |pages= 189–96 |year= 1991 |pmid= 1831431 |doi=10.1016/0378-1119(91)90077-O  }}
-*{{cite journal  | author=Nelissen RL, Sillekens PT, Beijer RP, ''et al.'' |title=Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. |journal=Gene |volume=102 |issue= 2 |pages= 189-96 |year= 1991 |pmid= 1831431 |doi=  }}
+*{{cite journal   |vauthors=Jessen TH, Oubridge C, Teo CH, etal |title=Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. |journal=EMBO J. |volume=10 |issue= 11 |pages= 3447–56 |year= 1991 |pmid= 1833186 |doi=  | pmc=453073  }}
-*{{cite journal  | author=Jessen TH, Oubridge C, Teo CH, ''et al.'' |title=Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. |journal=EMBO J. |volume=10 |issue= 11 |pages= 3447-56 |year= 1991 |pmid= 1833186 |doi=  }}
+*{{cite journal   |vauthors=Nagai K, Oubridge C, Jessen TH, etal |title=Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. |journal=Nature |volume=348 |issue= 6301 |pages= 515–20 |year= 1991 |pmid= 2147232 |doi= 10.1038/348515a0 }}
-*{{cite journal  | author=Nagai K, Oubridge C, Jessen TH, ''et al.'' |title=Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. |journal=Nature |volume=348 |issue= 6301 |pages= 515-20 |year= 1991 |pmid= 2147232 |doi= 10.1038/348515a0 }}
+*{{cite journal  |vauthors=Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ |title=cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. |journal=EMBO J. |volume=6 |issue= 12 |pages= 3841–8 |year= 1988 |pmid= 2962859 |doi=  | pmc=553857  }}
-*{{cite journal  | author=Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ |title=cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. |journal=EMBO J. |volume=6 |issue= 12 |pages= 3841-8 |year= 1988 |pmid= 2962859 |doi=  }}
+*{{cite journal   |vauthors=Oubridge C, Ito N, Evans PR, etal |title=Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. |journal=Nature |volume=372 |issue= 6505 |pages= 432–8 |year= 1994 |pmid= 7984237 |doi= 10.1038/372432a0 }}
-*{{cite journal  | author=Oubridge C, Ito N, Evans PR, ''et al.'' |title=Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. |journal=Nature |volume=372 |issue= 6505 |pages= 432-8 |year= 1994 |pmid= 7984237 |doi= 10.1038/372432a0 }}
+*{{cite journal  |vauthors=Howe PW, Nagai K, Neuhaus D, Varani G |title=NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3873–81 |year= 1994 |pmid= 8070414 |doi=  | pmc=395300  }}
-*{{cite journal  | author=Howe PW, Nagai K, Neuhaus D, Varani G |title=NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3873-81 |year= 1994 |pmid= 8070414 |doi=  }}
+*{{cite journal   |vauthors=Allain FH, Gubser CC, Howe PW, etal |title=Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. |journal=Nature |volume=380 |issue= 6575 |pages= 646–50 |year= 1996 |pmid= 8602269 |doi= 10.1038/380646a0 }}
-*{{cite journal  | author=Allain FH, Gubser CC, Howe PW, ''et al.'' |title=Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. |journal=Nature |volume=380 |issue= 6575 |pages= 646-50 |year= 1996 |pmid= 8602269 |doi= 10.1038/380646a0 }}
+*{{cite journal   |vauthors=Avis JM, Allain FH, Howe PW, etal |title=Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. |journal=J. Mol. Biol. |volume=257 |issue= 2 |pages= 398–411 |year= 1996 |pmid= 8609632 |doi= 10.1006/jmbi.1996.0171 }}
-*{{cite journal  | author=Avis JM, Allain FH, Howe PW, ''et al.'' |title=Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. |journal=J. Mol. Biol. |volume=257 |issue= 2 |pages= 398-411 |year= 1996 |pmid= 8609632 |doi= 10.1006/jmbi.1996.0171 }}
+*{{cite journal  |vauthors=Lu J, Hall KB |title=Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. |journal=Biochemistry |volume=36 |issue= 34 |pages= 10393–405 |year= 1997 |pmid= 9265619 |doi= 10.1021/bi9709811 }}
-*{{cite journal  | author=Lu J, Hall KB |title=Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. |journal=Biochemistry |volume=36 |issue= 34 |pages= 10393-405 |year= 1997 |pmid= 9265619 |doi= 10.1021/bi9709811 }}
+*{{cite journal  |vauthors=Allain FH, Howe PW, Neuhaus D, Varani G |title=Structural basis of the RNA-binding specificity of human U1A protein. |journal=EMBO J. |volume=16 |issue= 18 |pages= 5764–72 |year= 1997 |pmid= 9312034 |doi= 10.1093/emboj/16.18.5764  | pmc=1170207 }}
-*{{cite journal  | author=Allain FH, Howe PW, Neuhaus D, Varani G |title=Structural basis of the RNA-binding specificity of human U1A protein. |journal=EMBO J. |volume=16 |issue= 18 |pages= 5764-72 |year= 1997 |pmid= 9312034 |doi= 10.1093/emboj/16.18.5764 }}
+*{{cite journal   |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
-*{{cite journal  | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
+*{{cite journal  |vauthors=Ferré-D'Amaré AR, Zhou K, Doudna JA |title=Crystal structure of a hepatitis delta virus ribozyme. |journal=Nature |volume=395 |issue= 6702 |pages= 567–74 |year= 1998 |pmid= 9783582 |doi= 10.1038/26912 }}
-*{{cite journal  | author=Ferré-D'Amaré AR, Zhou K, Doudna JA |title=Crystal structure of a hepatitis delta virus ribozyme. |journal=Nature |volume=395 |issue= 6702 |pages= 567-74 |year= 1998 |pmid= 9783582 |doi= 10.1038/26912 }}
+*{{cite journal   |vauthors=Lutz CS, Cooke C, O'Connor JP, etal |title=The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. |journal=RNA |volume=4 |issue= 12 |pages= 1493–9 |year= 1998 |pmid= 9848648 |doi=10.1017/S1355838298981183  | pmc=1369720  }}
-*{{cite journal  | author=Lutz CS, Cooke C, O'Connor JP, ''et al.'' |title=The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. |journal=RNA |volume=4 |issue= 12 |pages= 1493-9 |year= 1998 |pmid= 9848648 |doi=  }}
+*{{cite journal  |vauthors=Hetzer M, Mattaj IW |title=An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. |journal=J. Cell Biol. |volume=148 |issue= 2 |pages= 293–303 |year= 2000 |pmid= 10648562 |doi=10.1083/jcb.148.2.293  | pmc=2174293  }}
-*{{cite journal  | author=Hetzer M, Mattaj IW |title=An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. |journal=J. Cell Biol. |volume=148 |issue= 2 |pages= 293-303 |year= 2000 |pmid= 10648562 |doi=  }}
+*{{cite journal   |vauthors=Klein Gunnewiek JM, Hussein RI, van Aarssen Y, etal |title=Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2209–17 |year= 2000 |pmid= 10688667 |doi=10.1128/MCB.20.6.2209-2217.2000  | pmc=110837  }}
-*{{cite journal  | author=Klein Gunnewiek JM, Hussein RI, van Aarssen Y, ''et al.'' |title=Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2209-17 |year= 2000 |pmid= 10688667 |doi=  }}
+*{{cite journal   |vauthors=Varani L, Gunderson SI, Mattaj IW, etal |title=The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. |journal=Nat. Struct. Biol. |volume=7 |issue= 4 |pages= 329–35 |year= 2000 |pmid= 10742179 |doi= 10.1038/74101 }}
-*{{cite journal  | author=Varani L, Gunderson SI, Mattaj IW, ''et al.'' |title=The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. |journal=Nat. Struct. Biol. |volume=7 |issue= 4 |pages= 329-35 |year= 2000 |pmid= 10742179 |doi= 10.1038/74101 }}
+*{{cite journal   |vauthors=Ajuh P, Kuster B, Panov K, etal |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569–81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569  | pmc=305846 }}
-*{{cite journal  | author=Ajuh P, Kuster B, Panov K, ''et al.'' |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569-81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 }}
+*{{cite journal  |vauthors=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. |journal=Immunity |volume=14 |issue= 6 |pages= 763–77 |year= 2001 |pmid= 11420046 |doi=10.1016/S1074-7613(01)00158-3  }}
-*{{cite journal  | author=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. |journal=Immunity |volume=14 |issue= 6 |pages= 763-77 |year= 2001 |pmid= 11420046 |doi=  }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=6626}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Ribonucleoproteins}}
 {{gene-19-stub}}
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v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

Small nuclear ribonucleoprotein polypeptide A: Difference between revisions

Revision as of 00:03, 12 September 2017

Interactions

References

Further reading

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