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{{Infobox_gene}}
{{PBB_Controls
'''Fms-related tyrosine kinase 3 ligand''' ('''FLT3LG''') is a [[protein]] which in humans is encoded by the ''FLT3LG'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2323| accessdate = }}</ref><ref name="pmid8145851">{{cite journal |vauthors=Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J | title = Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs | journal = Nature | volume = 368 | issue = 6472 | pages = 643–8 |date=April 1994 | pmid = 8145851 | doi = 10.1038/368643a0 | url =  }}</ref><ref name="pmid7824267">{{cite journal |vauthors=Lyman SD, James L, Escobar S, Downey H, de Vries P, Brasel K, Stocking K, Beckmann MP, Copeland NG, Cleveland LS | title = Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs | journal = Oncogene | volume = 10 | issue = 1 | pages = 149–57 |date=January 1995 | pmid = 7824267 | doi = | url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Flt3 ligand (FL) is a [[haematopoiesis|hematopoietic]] four helical bundle [[cytokine]]. It is structurally homologous to [[stem cell factor]] (SCF) and colony stimulating factor 1 ([[Macrophage colony-stimulating factor|CSF-1]]). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell [[progenitor cell|progenitors]]. For example, it is a major growth factor stimulating the growth of [[dendritic cells]].<ref>{{cite journal|last1=Harsuncky|first1=H|title=Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo|journal=J Exp Med|date=Jul 21 2003|doi=10.1084/jem.20030323|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194067/}}</ref>
{{GNF_Protein_box
| image = PBB_Protein_FLT3LG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ete.
| PDB = {{PDB2|1ete}}
| Name = Fms-related tyrosine kinase 3 ligand
| HGNCid = 3766
| Symbol = FLT3LG
| AltSymbols =;
| OMIM = 600007
| ECnumber = 
| Homologene = 48021
| MGIid = 95560
| GeneAtlas_image1 = PBB_GE_FLT3LG_210607_at_tn.png
| GeneAtlas_image2 = PBB_GE_FLT3LG_206980_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030098 |text = lymphocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2323
    | Hs_Ensembl = ENSG00000090554
    | Hs_RefseqProtein = NP_001450
    | Hs_RefseqmRNA = NM_001459
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 54669298
    | Hs_GenLoc_end = 54681299
    | Hs_Uniprot = P49771
    | Mm_EntrezGene = 14256
    | Mm_Ensembl = ENSMUSG00000074129
    | Mm_RefseqmRNA = NM_013520
    | Mm_RefseqProtein = NP_038548
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44999231
    | Mm_GenLoc_end = 45004474
    | Mm_Uniprot = Q61104
  }}
}}
'''Fms-related tyrosine kinase 3 ligand''', also known as '''FLT3LG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2323| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lyman SD, James L, Vanden Bos T, ''et al.'' |title=Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. |journal=Cell |volume=75 |issue= 6 |pages= 1157-67 |year= 1994 |pmid= 7505204 |doi=  }}
*{{cite journal  | author=Lyman SD |title=Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells |journal=Cell |volume=75 |issue= 6 |pages= 1157–67 |year= 1994 |pmid= 7505204 |doi=10.1016/0092-8674(93)90325-K |name-list-format=vanc| author2=James L | author3=Vanden Bos T  | display-authors=3  | last4=De Vries  | first4=Peter  | last5=Brasel  | first5=Ken  | last6=Gliniak  | first6=Brian  | last7=Hollingsworth  | first7=L.T.  | last8=Picha  | first8=Kathleen S.  | last9=McKenna  | first9=Hilary J. }}
*{{cite journal | author=Lyman SD, Stocking K, Davison B, ''et al.'' |title=Structural analysis of human and murine flt3 ligand genomic loci. |journal=Oncogene |volume=11 |issue= 6 |pages= 1165-72 |year= 1995 |pmid= 7566977 |doi=  }}
*{{cite journal  | author=Lyman SD |title=Structural analysis of human and murine flt3 ligand genomic loci |journal=Oncogene |volume=11 |issue= 6 |pages= 1165–72 |year= 1995 |pmid= 7566977 |doi=  |name-list-format=vanc| author2=Stocking K | author3=Davison B  | display-authors=3  | last4=Fletcher  | first4=F  | last5=Johnson  | first5=L  | last6=Escobar  | first6=S  }}
*{{cite journal  | author=Lyman SD, James L, Escobar S, ''et al.'' |title=Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. |journal=Oncogene |volume=10 |issue= 1 |pages= 149-57 |year= 1995 |pmid= 7824267 |doi=  }}
*{{cite journal  | author=Lyman SD |title=Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs |journal=Oncogene |volume=10 |issue= 1 |pages= 149–57 |year= 1995 |pmid= 7824267 |doi=  |name-list-format=vanc| author2=James L  | author3=Escobar S  | display-authors=3  | last4=Downey  | first4=H  | last5=De Vries  | first5=P  | last6=Brasel  | first6=K  | last7=Stocking | first7=K  | last8=Beckmann  | first8=MP  | last9=Copeland  | first9=NG  }}
*{{cite journal | author=Hannum C, Culpepper J, Campbell D, ''et al.'' |title=Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. |journal=Nature |volume=368 |issue= 6472 |pages= 643-8 |year= 1994 |pmid= 8145851 |doi= 10.1038/368643a0 }}
*{{cite journal  | author=Hannum C |title=Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs |journal=Nature |volume=368 |issue= 6472 |pages= 643–8 |year= 1994 |pmid= 8145851 |doi= 10.1038/368643a0 |name-list-format=vanc| author2=Culpepper J  | author3=Campbell D  | display-authors=3  | last4=McClanahan  | first4=T.  | last5=Zurawski  | first5=S.  | last6=Kastelein  | first6=R. | last7=Bazan | first7=J. F.  | last8=Hudak  | first8=S. | last9=Wagner  | first9=J. }}
*{{cite journal  | author=Lyman SD, James L, Johnson L, ''et al.'' |title=Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. |journal=Blood |volume=83 |issue= 10 |pages= 2795-801 |year= 1994 |pmid= 8180375 |doi= }}
*{{cite journal  | author=Lyman SD |title=Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells |journal=Blood |volume=83 |issue= 10 |pages= 2795–801 |year= 1994 |pmid= 8180375 |doi=  |name-list-format=vanc| author2=James L | author3=Johnson L  | display-authors=3  | last4=Brasel  | first4=K  | last5=De Vries  | first5=P  | last6=Escobar  | first6=SS  | last7=Downey  | first7=H | last8=Splett  | first8=RR  | last9=Beckmann  | first9=MP  }}
*{{cite journal | author=Slanicka Krieger M, Nissen C, Manz CY, ''et al.'' |title=The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow. |journal=Exp. Hematol. |volume=26 |issue= 5 |pages= 365-73 |year= 1998 |pmid= 9590652 |doi=  }}
*{{cite journal  | author=Slanicka Krieger M |title=The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow |journal=Exp. Hematol. |volume=26 |issue= 5 |pages= 365–73 |year= 1998 |pmid= 9590652 |doi=  |name-list-format=vanc| author2=Nissen C  | author3=Manz CY  | display-authors=3  | last4=Toksoz  | first4=D  | last5=Lyman  | first5=SD  | last6=Wodnar-Filipowicz  | first6=A  }}
*{{cite journal  | author=Graddis TJ, Brasel K, Friend D, ''et al.'' |title=Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17626-33 |year= 1998 |pmid= 9651358 |doi= }}
*{{cite journal  | author=Graddis TJ |title=Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17626–33 |year= 1998 |pmid= 9651358 |doi=10.1074/jbc.273.28.17626 |name-list-format=vanc| author2=Brasel K  | author3=Friend D  | display-authors=3 | last4=Srinivasan  | first4=S  | last5=Wee  | first5=S  | last6=Lyman  | first6=SD  | last7=March  | first7=CJ  | last8=McGrew  | first8=JT }}
*{{cite journal | author=Solanilla A, Grosset C, Lemercier C, ''et al.'' |title=Expression of Flt3-ligand by the endothelial cell. |journal=Leukemia |volume=14 |issue= 1 |pages= 153-62 |year= 2000 |pmid= 10637491 |doi=  }}
*{{cite journal  | author=Solanilla A |title=Expression of Flt3-ligand by the endothelial cell |journal=Leukemia |volume=14 |issue= 1 |pages= 153–62 |year= 2000 |pmid= 10637491 |doi=10.1038/sj.leu.2401635 |name-list-format=vanc| author2=Grosset C | author3=Lemercier C  | display-authors=3  | last4=Dupouy  | first4=M  | last5=Mahon  | first5=F X  | last6=Schweitzer  | first6=K  | last7=Reiffers  | first7=J  | last8=Weksler  | first8=B  | last9=Ripoche  | first9=J  }}
*{{cite journal | author=Savvides SN, Boone T, Andrew Karplus P |title=Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. |journal=Nat. Struct. Biol. |volume=7 |issue= 6 |pages= 486-91 |year= 2000 |pmid= 10881197 |doi= 10.1038/75896 }}
*{{cite journal  |author1=Savvides SN |author2=Boone T |author3=Karplus P.A. |title=Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots |journal=Nat. Struct. Biol. |volume=7 |issue= 6 |pages= 486–91 |year= 2000 |pmid= 10881197 |doi= 10.1038/75896 }}
*{{cite journal  | author=Chklovskaia E, Nissen C, Landmann L, ''et al.'' |title=Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A. |journal=Blood |volume=97 |issue= 4 |pages= 1027-34 |year= 2001 |pmid= 11159533 |doi=  }}
*{{cite journal  | author=Chklovskaia E |title=Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A |journal=Blood |volume=97 |issue= 4 |pages= 1027–34 |year= 2001 |pmid= 11159533 |doi=10.1182/blood.V97.4.1027 |name-list-format=vanc| author2=Nissen C  | author3=Landmann L  | display-authors=3  | last4=Rahner  | first4=C  | last5=Pfister  | first5=O  | last6=Wodnar-Filipowicz  | first6=A }}
*{{cite journal | author=Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE |title=Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model. |journal=Int. Immunopharmacol. |volume=1 |issue= 12 |pages= 2081-9 |year= 2002 |pmid= 11710537 |doi=  }}
*{{cite journal  |vauthors=Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE |title=Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model |journal=Int. Immunopharmacol. |volume=1 |issue= 12 |pages= 2081–9 |year= 2002 |pmid= 11710537 |doi=10.1016/S1567-5769(01)00122-9  }}
*{{cite journal  | author=Li H, Cai Y, Xu J |title=[Localization of a FLT3 ligand isoform in human tissues] |journal=Zhonghua Xue Ye Xue Za Zhi |volume=20 |issue= 6 |pages= 285-7 |year= 2002 |pmid= 11721383 |doi=  }}
*{{cite journal  |vauthors=Li H, Cai Y, Xu J |title=[Localization of a FLT3 ligand isoform in human tissues] |journal=Zhonghua Xue Ye Xue Za Zhi |volume=20 |issue= 6 |pages= 285–7 |year= 2002 |pmid= 11721383 |doi=  }}
*{{cite journal  | author=Feugier P, Jo DY, Shieh JH, ''et al.'' |title=Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand. |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 1 |pages= 127-38 |year= 2003 |pmid= 11847009 |doi= 10.1089/152581602753448595 }}
*{{cite journal  | author=Feugier P |title=Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 1 |pages= 127–38 |year= 2003 |pmid= 11847009 |doi= 10.1089/152581602753448595  |name-list-format=vanc| author2=Jo DY  | author3=Shieh JH  | display-authors=3  | last4=MacKenzie  | first4=Karen L.  | last5=Rafii  | first5=Shahin  | last6=Crystal  | first6=Ronald G.  | last7=Moore  | first7=Malcolm A.S. }}
*{{cite journal | author=O'Keeffe M, Hochrein H, Vremec D, ''et al.'' |title=Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. |journal=Blood |volume=99 |issue= 6 |pages= 2122-30 |year= 2002 |pmid= 11877288 |doi=  }}
*{{cite journal  | author=O'Keeffe M |title=Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice |journal=Blood |volume=99 |issue= 6 |pages= 2122–30 |year= 2002 |pmid= 11877288 |doi=10.1182/blood.V99.6.2122  |name-list-format=vanc| author2=Hochrein H  | author3=Vremec D  | display-authors=3  | last4=Pooley  | first4=J  | last5=Evans  | first5=R  | last6=Woulfe  | first6=S  | last7=Shortman  | first7=K  }}
*{{cite journal  | author=Retzlaff S, Padró T, Koch P, ''et al.'' |title=Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma. |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 525-7 |year= 2002 |pmid= 11956621 |doi=  }}
*{{cite journal  | author=Retzlaff S |title=Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 525–7 |year= 2002 |pmid= 11956621 |doi=  10.3892/or.9.3.525|name-list-format=vanc| author2=Padró T  | author3=Koch P  | display-authors=3  | last4=Oelmann  | first4=E  | last5=Lügering  | first5=N  | last6=Mesters  | first6=RM  | last7=Berdel  | first7=WE  }}
*{{cite journal | author=Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V, ''et al.'' |title=Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells. |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 2 |pages= 389-400 |year= 2003 |pmid= 11983110 |doi= 10.1089/152581602753658574 }}
*{{cite journal  | author=Sigurjónsson OE |title=Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 2 |pages= 389–400 |year= 2003 |pmid= 11983110 |doi= 10.1089/152581602753658574  |name-list-format=vanc| author2=Gudmundsson KO  | author3=Haraldsdóttir V  | display-authors=3  | last4=Rafnar  | first4=Thorunn  | last5=Gudmundsson  | first5=Sveinn }}
*{{cite journal  | author=Vávrová J, Vokurková D, Mareková M, ''et al.'' |title=Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. |journal=Folia Biol. (Praha) |volume=48 |issue= 2 |pages= 51-7 |year= 2002 |pmid= 12002675 |doi= }}
*{{cite journal  | author=Vávrová J |title=Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells |journal=Folia Biol. (Praha) |volume=48 |issue= 2 |pages= 51–7 |year= 2002 |pmid= 12002675 |doi=  |name-list-format=vanc| author2=Vokurková D  | author3=Mareková M  | display-authors=3  | last4=Bláha  | first4=M  | last5=Jebavý  | first5=L  | last6=Filip  | first6=S  }}
*{{cite journal  | author=Testa U, Torelli GF, Riccioni R, ''et al.'' |title=Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors. |journal=Blood |volume=99 |issue= 12 |pages= 4634-7 |year= 2002 |pmid= 12036900 |doi=  }}
*{{cite journal  | author=Testa U |title=Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors |journal=Blood |volume=99 |issue= 12 |pages= 4634–7 |year= 2002 |pmid= 12036900 |doi=10.1182/blood.V99.12.4634  |name-list-format=vanc| author2=Torelli GF  | author3=Riccioni R  | display-authors=3  | last4=Muta  | first4=AO  | last5=Militi  | first5=S  | last6=Annino  | first6=L  | last7=Mariani  | first7=G  | last8=Guarini  | first8=A  | last9=Chiaretti  | first9=S  }}
*{{cite journal  | author=Mosca PJ, Hobeika AC, Colling K, ''et al.'' |title=Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. |journal=J. Leukoc. Biol. |volume=72 |issue= 3 |pages= 546-53 |year= 2002 |pmid= 12223523 |doi=  }}
*{{cite journal  | author=Mosca PJ |title=Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand |journal=J. Leukoc. Biol. |volume=72 |issue= 3 |pages= 546–53 |year= 2002 |pmid= 12223523 |doi=  |name-list-format=vanc| author2=Hobeika AC  | author3=Colling K  | display-authors=3  | last4=Clay  | first4=TM  | last5=Thomas  | first5=EK  | last6=Caron  | first6=D  | last7=Lyerly  | first7=HK  | last8=Morse  | first8=MA  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2323}}


{{protein-stub}}
{{Regulome
{{WikiDoc Sources}}
| activates = [[MAP kinase]], [[FLT3]], [[STAT5A]]
| inhibits = [[tyrosine kinase]], PSA
| activated_by =
| inhibited_by =
}}
 
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Revision as of 11:09, 24 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.[1][2][3]

Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major growth factor stimulating the growth of dendritic cells.[4]

References

  1. ↑ "Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand".
  2. ↑ Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J (April 1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature. 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
  3. ↑ Lyman SD, James L, Escobar S, Downey H, de Vries P, Brasel K, Stocking K, Beckmann MP, Copeland NG, Cleveland LS (January 1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene. 10 (1): 149–57. PMID 7824267.
  4. ↑ Harsuncky, H (Jul 21 2003). "Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo". J Exp Med. doi:10.1084/jem.20030323. Check date values in: |date= (help)

Further reading

  • Lyman SD, James L, Vanden Bos T, et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells". Cell. 75 (6): 1157–67. doi:10.1016/0092-8674(93)90325-K. PMID 7505204.
  • Lyman SD, Stocking K, Davison B, et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci". Oncogene. 11 (6): 1165–72. PMID 7566977.
  • Lyman SD, James L, Escobar S, et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene. 10 (1): 149–57. PMID 7824267.
  • Hannum C, Culpepper J, Campbell D, et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature. 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
  • Lyman SD, James L, Johnson L, et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". Blood. 83 (10): 2795–801. PMID 8180375.
  • Slanicka Krieger M, Nissen C, Manz CY, et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow". Exp. Hematol. 26 (5): 365–73. PMID 9590652.
  • Graddis TJ, Brasel K, Friend D, et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen". J. Biol. Chem. 273 (28): 17626–33. doi:10.1074/jbc.273.28.17626. PMID 9651358.
  • Solanilla A, Grosset C, Lemercier C, et al. (2000). "Expression of Flt3-ligand by the endothelial cell". Leukemia. 14 (1): 153–62. doi:10.1038/sj.leu.2401635. PMID 10637491.
  • Savvides SN; Boone T; Karplus P.A. (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197.
  • Chklovskaia E, Nissen C, Landmann L, et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood. 97 (4): 1027–34. doi:10.1182/blood.V97.4.1027. PMID 11159533.
  • Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE (2002). "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model". Int. Immunopharmacol. 1 (12): 2081–9. doi:10.1016/S1567-5769(01)00122-9. PMID 11710537.
  • Li H, Cai Y, Xu J (2002). "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi. 20 (6): 285–7. PMID 11721383.
  • Feugier P, Jo DY, Shieh JH, et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009.
  • O'Keeffe M, Hochrein H, Vremec D, et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice". Blood. 99 (6): 2122–30. doi:10.1182/blood.V99.6.2122. PMID 11877288.
  • Retzlaff S, Padró T, Koch P, et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma". Oncol. Rep. 9 (3): 525–7. doi:10.3892/or.9.3.525. PMID 11956621.
  • Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V, et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110.
  • Vávrová J, Vokurková D, Mareková M, et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells". Folia Biol. (Praha). 48 (2): 51–7. PMID 12002675.
  • Testa U, Torelli GF, Riccioni R, et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood. 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.
  • Mosca PJ, Hobeika AC, Colling K, et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand". J. Leukoc. Biol. 72 (3): 546–53. PMID 12223523.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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