CAPNS1: Difference between revisions

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Revision as of 19:49, 1 November 2017

Calpain small subunit 1, also known as CAPN4, is a protein that in humans is encoded by the CAPNS1 gene.^[1]^[2]^[3]

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Two transcript variants encoding the same protein have been identified for this gene.^[3]

Functions

Myotonic dystrophy

This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.^[3]

Biomarker

Elevated expression of Capn4 has been found to be associated with progression of various cancers such as hepatocellular and renal carcinoma. ^[4]

References

↑ Miyake S, Emori Y, Suzuki K (Jan 1987). "Gene organization of the small subunit of human calcium-activated neutral protease". Nucleic Acids Res. 14 (22): 8805–17. doi:10.1093/nar/14.22.8805. PMC 311912. PMID 3024120.
↑ Ohno S, Emori Y, Suzuki K (Sep 1986). "Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease". Nucleic Acids Res. 14 (13): 5559. PMC 311560. PMID 3016651.
↑ ^3.0 ^3.1 ^3.2 "Entrez Gene: CAPNS1 calpain, small subunit 1".
↑ Zhuang Q (Apr 2014). "Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma". J Int Med Res. 42: 282–91. doi:10.1177/0300060513505524. PMID 24514433.

External links

Human CAPNS1 genome location and CAPNS1 gene details page in the UCSC Genome Browser.

Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function". Biol. Chem. Hoppe-Seyler. 376 (9): 523–9. PMID 8561910.
Tidball JG, Spencer MJ (2000). "Calpains and muscular dystrophies". Int. J. Biochem. Cell Biol. 32 (1): 1–5. doi:10.1016/S1357-2725(99)00095-3. PMID 10661889.
Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355–62. doi:10.1016/S1471-4914(01)02049-4. PMID 11516996.
Reverter D, Sorimachi H, Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function". Trends Cardiovasc. Med. 11 (6): 222–9. doi:10.1016/S1050-1738(01)00112-8. PMID 11673052.
Banik NL, DeVries GH, Neuberger T, et al. (1991). "Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP". J. Neurosci. Res. 29 (3): 346–54. doi:10.1002/jnr.490290310. PMID 1656060.
Ohno S, Minoshima S, Kudoh J, et al. (1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenet. Cell Genet. 53 (4): 225–9. doi:10.1159/000132937. PMID 2209092.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Zhang W, Lane RD, Mellgren RL (1996). "The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells". J. Biol. Chem. 271 (31): 18825–30. doi:10.1074/jbc.271.31.18825. PMID 8702541.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Noguchi M, Sarin A, Aman MJ, et al. (1997). "Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11534–9. doi:10.1073/pnas.94.21.11534. PMC 23528. PMID 9326644.
Strobl S, Fernandez-Catalan C, Braun M, et al. (2000). "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 588–92. doi:10.1073/pnas.97.2.588. PMC 15374. PMID 10639123.
Masumoto H, Nakagawa K, Irie S, et al. (2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain". Acta Crystallogr. D. 56 (Pt 1): 73–5. doi:10.1107/S0907444999013748. PMID 10666632.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Reverter D, Strobl S, Fernandez-Catalan C, et al. (2002). "Structural basis for possible calcium-induced activation mechanisms of calpains". Biol. Chem. 382 (5): 753–66. doi:10.1515/BC.2001.091. PMID 11517928.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid3024120-1] Miyake S, Emori Y, Suzuki K (Jan 1987). "Gene organization of the small subunit of human calcium-activated neutral protease". Nucleic Acids Res. 14 (22): 8805–17. doi:10.1093/nar/14.22.8805. PMC 311912. PMID 3024120.

[pmid3016651-2] Ohno S, Emori Y, Suzuki K (Sep 1986). "Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease". Nucleic Acids Res. 14 (13): 5559. PMC 311560. PMID 3016651.

[entrez-3] 3.0 ^3.1 ^3.2 "Entrez Gene: CAPNS1 calpain, small subunit 1".

[pmid_=_24514433-4] Zhuang Q (Apr 2014). "Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma". J Int Med Res. 42: 282–91. doi:10.1177/0300060513505524. PMID 24514433.

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@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Calpain small subunit 1''', also known as '''CAPN4''', is a [[protein]] that in humans is encoded by the ''CAPNS1'' [[gene]].<ref name="pmid3024120">{{cite journal | vauthors = Miyake S, Emori Y, Suzuki K | title = Gene organization of the small subunit of human calcium-activated neutral protease | journal = Nucleic Acids Res | volume = 14 | issue = 22 | pages = 8805–17 |date=Jan 1987 | pmid = 3024120 | pmc = 311912 | doi =10.1093/nar/14.22.8805  }}</ref><ref name="pmid3016651">{{cite journal | vauthors = Ohno S, Emori Y, Suzuki K | title = Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease | journal = Nucleic Acids Res | volume = 14 | issue = 13 | pages = 5559 |date=Sep 1986 | pmid = 3016651 | pmc = 311560 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=826| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CAPNS1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aj5.
- | PDB = {{PDB2|1aj5}}, {{PDB2|1alv}}, {{PDB2|1alw}}, {{PDB2|1df0}}, {{PDB2|1dvi}}, {{PDB2|1kfu}}, {{PDB2|1kfx}}, {{PDB2|1np8}}, {{PDB2|1nx0}}, {{PDB2|1nx1}}, {{PDB2|1nx2}}, {{PDB2|1nx3}}, {{PDB2|1u5i}}
- | Name = Calpain, small subunit 1
- | HGNCid = 1481
- | Symbol = CAPNS1
- | AltSymbols =; CANP; 30K; CALPAIN4; CANPS; CAPN4; CDPS
- | OMIM = 114170
- | ECnumber =
- | Homologene = 1327
- | MGIid = 88266
- | Function = {{GNF_GO|id=GO:0004198 |text = calpain activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 826
-    | Hs_Ensembl = ENSG00000126247
-    | Hs_RefseqProtein = NP_001003962
-    | Hs_RefseqmRNA = NM_001003962
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 41322757
-    | Hs_GenLoc_end = 41333095
-    | Hs_Uniprot = P04632
-    | Mm_EntrezGene = 12336
-    | Mm_Ensembl = ENSMUSG00000001794
-    | Mm_RefseqmRNA = XM_001000249
-    | Mm_RefseqProtein = XP_001000249
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 29895703
-    | Mm_GenLoc_end = 29903808
-    | Mm_Uniprot = O88456
-  }}
-}}
-'''Calpain, small subunit 1''', also known as '''CAPNS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=826| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=826| accessdate = }}</ref>
+| summary_text = Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez" />
 }}
+==Functions==
+===Myotonic dystrophy===
+This gene encodes a small subunit common to both calpain I and II and is associated with [[myotonic dystrophy]].<ref name="entrez" />
+===Biomarker===
+Elevated expression of Capn4 has been found to be associated with progression of various cancers such as hepatocellular and [[renal carcinoma]].
+<ref name=" pmid = 24514433 ">{{cite journal | author = Zhuang Q | title = Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma. | journal = J Int Med Res. | volume = 42 | issue = |date=Apr 2014 | pmid = 24514433 | url = http://imr.sagepub.com/content/42/2/282.long  | pages = 282–91 | doi=10.1177/0300060513505524}}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CAPNS1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Suzuki K, Sorimachi H, Yoshizawa T, ''et al.'' |title=Calpain: novel family members, activation, and physiologic function. |journal=Biol. Chem. Hoppe-Seyler |volume=376 |issue= 9 |pages= 523-9 |year= 1996 |pmid= 8561910 |doi=  }}
+*{{cite journal  | author=Suzuki K |title=Calpain: novel family members, activation, and physiologic function |journal=Biol. Chem. Hoppe-Seyler |volume=376 |issue= 9 |pages= 523–9 |year= 1996 |pmid= 8561910 |doi=  |name-list-format=vanc| author2=Sorimachi H  | author3=Yoshizawa T  | display-authors=3  | last4=Kinbara  | first4=K  | last5=Ishiura  | first5=S  }}
-*{{cite journal  | author=Tidball JG, Spencer MJ |title=Calpains and muscular dystrophies. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 1 |pages= 1-5 |year= 2000 |pmid= 10661889 |doi=  }}
+*{{cite journal  | vauthors=Tidball JG, Spencer MJ |title=Calpains and muscular dystrophies |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 1 |pages= 1–5 |year= 2000 |pmid= 10661889 |doi=10.1016/S1357-2725(99)00095-3  }}
-*{{cite journal  | author=Huang Y, Wang KK |title=The calpain family and human disease. |journal=Trends in molecular medicine |volume=7 |issue= 8 |pages= 355-62 |year= 2001 |pmid= 11516996 |doi=  }}
+*{{cite journal  | vauthors=Huang Y, Wang KK |title=The calpain family and human disease |journal=Trends in Molecular Medicine |volume=7 |issue= 8 |pages= 355–62 |year= 2001 |pmid= 11516996 |doi=10.1016/S1471-4914(01)02049-4  }}
-*{{cite journal  | author=Reverter D, Sorimachi H, Bode W |title=The structure of calcium-free human m-calpain: implications for calcium activation and function. |journal=Trends Cardiovasc. Med. |volume=11 |issue= 6 |pages= 222-9 |year= 2001 |pmid= 11673052 |doi=  }}
+*{{cite journal  | vauthors=Reverter D, Sorimachi H, Bode W |title=The structure of calcium-free human m-calpain: implications for calcium activation and function |journal=Trends Cardiovasc. Med. |volume=11 |issue= 6 |pages= 222–9 |year= 2001 |pmid= 11673052 |doi=10.1016/S1050-1738(01)00112-8  }}
-*{{cite journal  | author=Banik NL, DeVries GH, Neuberger T, ''et al.'' |title=Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP. |journal=J. Neurosci. Res. |volume=29 |issue= 3 |pages= 346-54 |year= 1991 |pmid= 1656060 |doi= 10.1002/jnr.490290310 }}
+*{{cite journal  | author=Banik NL |title=Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP |journal=J. Neurosci. Res. |volume=29 |issue= 3 |pages= 346–54 |year= 1991 |pmid= 1656060 |doi= 10.1002/jnr.490290310  |name-list-format=vanc| author2=DeVries GH  | author3=Neuberger T  | display-authors=3  | last4=Russell  | first4=T.  | last5=Chakrabarti  | first5=A. K.  | last6=Hogan  | first6=E. L. }}
-*{{cite journal  | author=Ohno S, Minoshima S, Kudoh J, ''et al.'' |title=Four genes for the calpain family locate on four distinct human chromosomes. |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 225-9 |year= 1990 |pmid= 2209092 |doi=  }}
+*{{cite journal  | author=Ohno S |title=Four genes for the calpain family locate on four distinct human chromosomes |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 225–9 |year= 1990 |pmid= 2209092 |doi=10.1159/000132937  |name-list-format=vanc| author2=Minoshima S  | author3=Kudoh J  | display-authors=3  | last4=Fukuyama  | first4=R.  | last5=Shimizu  | first5=Y.  | last6=Ohmi-Imajohs  | first6=S.  | last7=Shimizu  | first7=N.  | last8=Suzuki  | first8=K.  }}
-*{{cite journal  | author=Ohno S, Emori Y, Suzuki K |title=Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease. |journal=Nucleic Acids Res. |volume=14 |issue= 13 |pages= 5559 |year= 1986 |pmid= 3016651 |doi=  }}
+*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
-*{{cite journal  | author=Miyake S, Emori Y, Suzuki K |title=Gene organization of the small subunit of human calcium-activated neutral protease. |journal=Nucleic Acids Res. |volume=14 |issue= 22 |pages= 8805-17 |year= 1987 |pmid= 3024120 |doi=  }}
+*{{cite journal  | vauthors=Zhang W, Lane RD, Mellgren RL |title=The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18825–30 |year= 1996 |pmid= 8702541 |doi=10.1074/jbc.271.31.18825  }}
-*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
+*{{cite journal  | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
-*{{cite journal  | author=Zhang W, Lane RD, Mellgren RL |title=The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18825-30 |year= 1996 |pmid= 8702541 |doi=  }}
+*{{cite journal  | author=Noguchi M |title=Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11534–9 |year= 1997 |pmid= 9326644 |doi=10.1073/pnas.94.21.11534  | pmc=23528  |name-list-format=vanc| author2=Sarin A  | author3=Aman MJ  | display-authors=3  | last4=Nakajima  | first4=H  | last5=Shores  | first5=EW  | last6=Henkart  | first6=PA  | last7=Leonard  | first7=WJ  }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
+*{{cite journal  | author=Strobl S |title=The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 2 |pages= 588–92 |year= 2000 |pmid= 10639123 |doi=10.1073/pnas.97.2.588  | pmc=15374  |name-list-format=vanc| author2=Fernandez-Catalan C  | author3=Braun M  | display-authors=3  | last4=Huber  | first4=R  | last5=Masumoto  | first5=H  | last6=Nakagawa  | first6=K  | last7=Irie  | first7=A  | last8=Sorimachi  | first8=H  | last9=Bourenkow  | first9=G  }}
-*{{cite journal  | author=Noguchi M, Sarin A, Aman MJ, ''et al.'' |title=Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11534-9 |year= 1997 |pmid= 9326644 |doi=  }}
+*{{cite journal  | author=Masumoto H |title=Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain |journal=Acta Crystallogr. D |volume=56 |issue= Pt 1 |pages= 73–5 |year= 2000 |pmid= 10666632 |doi=10.1107/S0907444999013748  |name-list-format=vanc| author2=Nakagawa K  | author3=Irie S  | display-authors=3  | last4=Sorimachi  | first4=Hiroyuki  | last5=Suzuki  | first5=Koichi  | last6=Bourenkov  | first6=Gleb P.  | last7=Bartunik  | first7=Hans  | last8=Fernandez-Catalan  | first8=Carlos  | last9=Bode  | first9=Wolfram  }}
-*{{cite journal  | author=Strobl S, Fernandez-Catalan C, Braun M, ''et al.'' |title=The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 2 |pages= 588-92 |year= 2000 |pmid= 10639123 |doi=  }}
+*{{cite journal  | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |name-list-format=vanc| author2=Correa RG  | author3=Verjovski-Almeida S  | display-authors=3  | last4=Briones  | first4=MR  | last5=Nagai  | first5=MA  | last6=Da Silva Jr  | first6=W  | last7=Zago  | first7=MA  | last8=Bordin  | first8=S  | last9=Costa  | first9=FF  }}
-*{{cite journal  | author=Masumoto H, Nakagawa K, Irie S, ''et al.'' |title=Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=56 |issue= Pt 1 |pages= 73-5 |year= 2000 |pmid= 10666632 |doi=  }}
+*{{cite journal  | author=Reverter D |title=Structural basis for possible calcium-induced activation mechanisms of calpains |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 753–66 |year= 2002 |pmid= 11517928 |doi=10.1515/BC.2001.091  |name-list-format=vanc| author2=Strobl S  | author3=Fernandez-Catalan C  | display-authors=3  | last4=Sorimachi  | first4=H.  | last5=Suzuki  | first5=K.  | last6=Bode  | first6=W.  }}
-*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
-*{{cite journal  | author=Reverter D, Strobl S, Fernandez-Catalan C, ''et al.'' |title=Structural basis for possible calcium-induced activation mechanisms of calpains. |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 753-66 |year= 2002 |pmid= 11517928 |doi=  }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=826}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Cysteine proteases}}
+[[Category:EF-hand-containing proteins]]
-{{protein-stub}}
+{{gene-19-stub}}
-{{WikiDoc Sources}}

v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain