SRA1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Steroid receptor RNA activator 1''' also known as '''steroid receptor RNA activator protein''' (SRAP) is a [[protein]] that in humans is encoded by the ''SRA1'' [[gene]].<ref name="pmid10199399">{{cite journal | vauthors = Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW | title = A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex | journal = Cell | volume = 97 | issue = 1 | pages = 17–27 | date = April 1999 | pmid = 10199399 | pmc =  | doi = 10.1016/S0092-8674(00)80711-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRA1 steroid receptor RNA activator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10011| accessdate = }}</ref>  The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing [[nuclear receptor coactivator 1|NCOA1]]. This functional RNA also encodes a protein.<ref name="pmid15147866">{{cite journal | vauthors = Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E | title = The steroid receptor RNA activator is the first functional RNA encoding a protein | journal = FEBS Letters | volume = 566 | issue = 1-3 | pages = 43–7 | date = May 2004 | pmid = 15147866 | doi = 10.1016/j.febslet.2004.03.104 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Steroid receptor RNA activator 1
| HGNCid = 11281
| Symbol = SRA1
| AltSymbols =; MGC87674; SRA; SRAP; STRAA1; pp7684
| OMIM = 603819
| ECnumber = 
| Homologene = 11906
| MGIid = 1344414
| GeneAtlas_image1 = PBB_GE_SRA1_gnf1h06172_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10011
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001030312
    | Hs_RefseqmRNA = NM_001035235
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 24068
    | Mm_Ensembl = ENSMUSG00000006050
    | Mm_RefseqmRNA = NM_025291
    | Mm_RefseqProtein = NP_079567
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 36793221
    | Mm_GenLoc_end = 36796269
    | Mm_Uniprot = Q80VJ2
  }}
}}
'''Steroid receptor RNA activator 1''', also known as '''SRA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SRA1 steroid receptor RNA activator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10011| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is involved in [[Coactivation (Transcription)|transcriptional coactivation]] by [[steroid hormone receptor|steroid receptor]]. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is involved in transcriptional coactivation by steroid receptors. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.<ref name="entrez">{{cite web | title = Entrez Gene: SRA1 steroid receptor RNA activator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10011| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SRA1 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[Estrogen receptor alpha]],<ref name="pmid11250900">{{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = The EMBO Journal | volume = 20 | issue = 6 | pages = 1341–52 | date = March 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}</ref>
{{PBB_Further_reading
* [[DDX17]],<ref name=pmid11250900/>
| citations =
* [[Nuclear receptor coactivator 2]],<ref name=pmid11250900/> and
*{{cite journal  | author=Lanz RB, McKenna NJ, Onate SA, ''et al.'' |title=A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. |journal=Cell |volume=97 |issue= 1 |pages= 17-27 |year= 1999 |pmid= 10199399 |doi= }}
* [[SPEN]].<ref name="pmid11331609">{{cite journal | vauthors = Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM | title = Sharp, an inducible cofactor that integrates nuclear receptor repression and activation | journal = Genes & Development | volume = 15 | issue = 9 | pages = 1140–51 | date = May 2001 | pmid = 11331609 | pmc = 312688 | doi = 10.1101/gad.871201 }}</ref>
*{{cite journal | author=Leygue E, Dotzlaw H, Watson PH, Murphy LC |title=Expression of the steroid receptor RNA activator in human breast tumors. |journal=Cancer Res. |volume=59 |issue= 17 |pages= 4190-3 |year= 1999 |pmid= 10485452 |doi= }}
 
*{{cite journal | author=Murphy LC, Simon SL, Parkes A, ''et al.'' |title=Altered expression of estrogen receptor coregulators during human breast tumorigenesis. |journal=Cancer Res. |volume=60 |issue= 22 |pages= 6266-71 |year= 2000 |pmid= 11103781 |doi= }}
The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA.<ref name="pmid20855289">{{cite journal | vauthors = Hubé F, Velasco G, Rollin J, Furling D, Francastel C | title = Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation | journal = Nucleic Acids Research | volume = 39 | issue = 2 | pages = 513–25 | date = January 2011 | pmid = 20855289 | pmc = 3025577 | doi = 10.1093/nar/gkq833 }}</ref> Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.<ref>{{cite journal | vauthors = Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC | title = The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region | journal = Journal of Molecular Biology | volume = 426 | issue = 8 | pages = 1753–65 | date = April 2014 | pmid = 24486611 | doi = 10.1016/j.jmb.2014.01.007 }}</ref>
*{{cite journal | author=Watanabe M, Yanagisawa J, Kitagawa H, ''et al.'' |title=A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1341-52 |year= 2001 |pmid= 11250900 |doi= 10.1093/emboj/20.6.1341 }}
{{-}}
*{{cite journal  | author=Cavarretta IT, Mukopadhyay R, Lonard DM, ''et al.'' |title=Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. |journal=Mol. Endocrinol. |volume=16 |issue= 2 |pages= 253-70 |year= 2002 |pmid= 11818499 |doi= }}
 
*{{cite journal | author=Kucera T, Waltner-Law M, Scott DK, ''et al.'' |title=A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26098-102 |year= 2002 |pmid= 12118039 |doi= 10.1074/jbc.M204013200 }}
== References ==
*{{cite journal | author=Ueda T, Mawji NR, Bruchovsky N, Sadar MD |title=Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38087-94 |year= 2002 |pmid= 12163482 |doi= 10.1074/jbc.M203313200 }}
{{reflist|33em}}
*{{cite journal | author=Lanz RB, Razani B, Goldberg AD, O'Malley BW |title=Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16081-6 |year= 2003 |pmid= 12444263 |doi= 10.1073/pnas.192571399 }}
 
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
== Further reading ==
*{{cite journal | author=Emberley E, Huang GJ, Hamedani MK, ''et al.'' |title=Identification of new human coding steroid receptor RNA activator isoforms. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 509-15 |year= 2003 |pmid= 12565891 |doi=  }}
{{refbegin|33em}}
*{{cite journal | author=Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR |title=Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. |journal=J. Mol. Biol. |volume=331 |issue= 4 |pages= 815-28 |year= 2003 |pmid= 12909012 |doi= }}
* {{cite journal | vauthors = Ulveling D, Francastel C, Hubé F | title = When one is better than two: RNA with dual functions | journal = Biochimie | volume = 93 | issue = 4 | pages = 633–44 | date = April 2011 | pmid = 21111023 | doi = 10.1016/j.biochi.2010.11.004 }}
*{{cite journal | author=Deblois G, Giguère V |title=Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 123-31 |year= 2003 |pmid= 12943696 |doi= }}
* {{cite journal | vauthors = Hubé F, Velasco G, Rollin J, Furling D, Francastel C | title = Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation | journal = Nucleic Acids Research | volume = 39 | issue = 2 | pages = 513–25 | date = January 2011 | pmid = 20855289 | pmc = 3025577 | doi = 10.1093/nar/gkq833 }}
*{{cite journal | author=Lanz RB, Chua SS, Barron N, ''et al.'' |title=Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7163-76 |year= 2003 |pmid= 14517287 |doi= }}
* {{cite journal | vauthors = Cooper C, Guo J, Yan Y, Chooniedass-Kothari S, Hube F, Hamedani MK, Murphy LC, Myal Y, Leygue E | title = Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides | journal = Nucleic Acids Research | volume = 37 | issue = 13 | pages = 4518–31 | date = July 2009 | pmid = 19483093 | pmc = 2715257 | doi = 10.1093/nar/gkp441 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Hube F, Guo J, Chooniedass-Kothari S, Cooper C, Hamedani MK, Dibrov AA, Blanchard AA, Wang X, Deng G, Myal Y, Leygue E | title = Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines | journal = DNA and Cell Biology | volume = 25 | issue = 7 | pages = 418–28 | date = July 2006 | pmid = 16848684 | doi = 10.1089/dna.2006.25.418 }}
*{{cite journal | author=Fleming FJ, Hill AD, McDermott EW, ''et al.'' |title=Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 375-83 |year= 2004 |pmid= 14715875 |doi=  }}
* {{cite journal | vauthors = Leygue E, Dotzlaw H, Watson PH, Murphy LC | title = Expression of the steroid receptor RNA activator in human breast tumors | journal = Cancer Research | volume = 59 | issue = 17 | pages = 4190–3 | date = September 1999 | pmid = 10485452 | doi = }}
*{{cite journal | author=Chooniedass-Kothari S, Emberley E, Hamedani MK, ''et al.'' |title=The steroid receptor RNA activator is the first functional RNA encoding a protein. |journal=FEBS Lett. |volume=566 |issue= 1-3 |pages= 43-7 |year= 2004 |pmid= 15147866 |doi= 10.1016/j.febslet.2004.03.104 }}
* {{cite journal | vauthors = Murphy LC, Simon SL, Parkes A, Leygue E, Dotzlaw H, Snell L, Troup S, Adeyinka A, Watson PH | title = Altered expression of estrogen receptor coregulators during human breast tumorigenesis | journal = Cancer Research | volume = 60 | issue = 22 | pages = 6266–71 | date = November 2000 | pmid = 11103781 | doi =  }}
*{{cite journal | author=Xu B, Koenig RJ |title=An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33051-6 |year= 2004 |pmid= 15180993 |doi= 10.1074/jbc.M404930200 }}
* {{cite journal | vauthors = Cavarretta IT, Mukopadhyay R, Lonard DM, Cowsert LM, Bennett CF, O'Malley BW, Smith CL | title = Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 253–70 | date = February 2002 | pmid = 11818499 | doi = 10.1210/me.16.2.253 }}
*{{cite journal | author=Zhao X, Patton JR, Davis SL, ''et al.'' |title=Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 549-58 |year= 2004 |pmid= 15327771 |doi= 10.1016/j.molcel.2004.06.044 }}
* {{cite journal | vauthors = Kucera T, Waltner-Law M, Scott DK, Prasad R, Granner DK | title = A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26098–102 | date = July 2002 | pmid = 12118039 | doi = 10.1074/jbc.M204013200 }}
*{{cite journal | author=Coleman KM, Lam V, Jaber BM, ''et al.'' |title=SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 332-8 |year= 2004 |pmid= 15351741 |doi= 10.1016/j.bbrc.2004.08.090 }}
* {{cite journal | vauthors = Ueda T, Mawji NR, Bruchovsky N, Sadar MD | title = Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38087–94 | date = October 2002 | pmid = 12163482 | doi = 10.1074/jbc.M203313200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Lanz RB, Razani B, Goldberg AD, O'Malley BW | title = Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 25 | pages = 16081–6 | date = December 2002 | pmid = 12444263 | pmc = 138568 | doi = 10.1073/pnas.192571399 }}
}}
* {{cite journal | vauthors = Emberley E, Huang GJ, Hamedani MK, Czosnek A, Ali D, Grolla A, Lu B, Watson PH, Murphy LC, Leygue E | title = Identification of new human coding steroid receptor RNA activator isoforms | journal = Biochemical and Biophysical Research Communications | volume = 301 | issue = 2 | pages = 509–15 | date = February 2003 | pmid = 12565891 | doi = 10.1016/S0006-291X(02)03070-X }}
* {{cite journal | vauthors = Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR | title = Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor | journal = Journal of Molecular Biology | volume = 331 | issue = 4 | pages = 815–28 | date = August 2003 | pmid = 12909012 | doi = 10.1016/S0022-2836(03)00795-2 }}
* {{cite journal | vauthors = Deblois G, Giguère V | title = Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 85 | issue = 2-5 | pages = 123–31 | date = June 2003 | pmid = 12943696 | doi = 10.1016/S0960-0760(03)00225-5 }}
* {{cite journal | vauthors = Lanz RB, Chua SS, Barron N, Söder BM, DeMayo F, O'Malley BW | title = Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo | journal = Molecular and Cellular Biology | volume = 23 | issue = 20 | pages = 7163–76 | date = October 2003 | pmid = 14517287 | pmc = 230309 | doi = 10.1128/MCB.23.20.7163-7176.2003 }}
* {{cite journal | vauthors = Fleming FJ, Hill AD, McDermott EW, O'Higgins NJ, Young LS | title = Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 1 | pages = 375–83 | date = January 2004 | pmid = 14715875 | doi = 10.1210/jc.2003-031048 }}
* {{cite journal | vauthors = Xu B, Koenig RJ | title = An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33051–6 | date = August 2004 | pmid = 15180993 | doi = 10.1074/jbc.M404930200 }}
* {{cite journal | vauthors = Zhao X, Patton JR, Davis SL, Florence B, Ames SJ, Spanjaard RA | title = Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator | journal = Molecular Cell | volume = 15 | issue = 4 | pages = 549–58 | date = August 2004 | pmid = 15327771 | doi = 10.1016/j.molcel.2004.06.044 }}
* {{cite journal | vauthors = Coleman KM, Lam V, Jaber BM, Lanz RB, Smith CL | title = SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity | journal = Biochemical and Biophysical Research Communications | volume = 323 | issue = 1 | pages = 332–8 | date = October 2004 | pmid = 15351741 | doi = 10.1016/j.bbrc.2004.08.090 }}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|SRA1}}
* {{UCSC gene details|SRA1}}

Latest revision as of 06:58, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.[1][2] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.[3]

Function

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.[2]

Interactions

SRA1 has been shown to interact with:

The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA.[6] Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.[7]

References

  1. ↑ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (April 1999). "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex". Cell. 97 (1): 17–27. doi:10.1016/S0092-8674(00)80711-4. PMID 10199399.
  2. ↑ 2.0 2.1 "Entrez Gene: SRA1 steroid receptor RNA activator 1".
  3. ↑ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E (May 2004). "The steroid receptor RNA activator is the first functional RNA encoding a protein". FEBS Letters. 566 (1–3): 43–7. doi:10.1016/j.febslet.2004.03.104. PMID 15147866.
  4. ↑ 4.0 4.1 4.2 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". The EMBO Journal. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  5. ↑ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes & Development. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  6. ↑ Hubé F, Velasco G, Rollin J, Furling D, Francastel C (January 2011). "Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation". Nucleic Acids Research. 39 (2): 513–25. doi:10.1093/nar/gkq833. PMC 3025577. PMID 20855289.
  7. ↑ Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC (April 2014). "The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region". Journal of Molecular Biology. 426 (8): 1753–65. doi:10.1016/j.jmb.2014.01.007. PMID 24486611.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=SRA1&oldid=1420325"