Tenascin X: Difference between revisions

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{{protein
{{Infobox_gene}}
|Name=tenascin XB
|caption=
|image=
|width=
|HGNCid=11976
|Symbol=TNXB
|AltSymbols=TNXB1, TNXB2
|EntrezGene=7148
|OMIM=600985
|RefSeq=NM_019105
|UniProt=P22105
|PDB=
|ECnumber=
|Chromosome=6
|Arm=p
|Band=21.3
|LocusSupplementaryData=
}}
{{protein
|Name=tenascin XA pseudogene
|caption=
|image=
|width=
|HGNCid=11975
|Symbol=TNXA
|AltSymbols=TNX
|EntrezGene=7146
|OMIM=
|RefSeq=NR_001284
|UniProt=
|PDB=
|ECnumber=
|Chromosome=6
|Arm=p
|Band=21.3
|LocusSupplementaryData=
}}


A member of the [[tenascin]] family, '''tenascin X''' (TN-X) also known as '''hexabrachion-like protein''' is a [[glycoprotein]] that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the ''TNXB'' [[gene]].<ref name="pmid8530023">{{cite journal |vauthors=Tee MK, Thomson AA, Bristow J, Miller WL | title = Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X | journal = Genomics | volume = 28 | issue = 2 | pages = 171–8 |date=July 1995 | pmid = 8530023 | doi = 10.1006/geno.1995.1128 | url = | issn = }}</ref>


== Gene ==


'''Tenascin X''' is a type of [[Tenascin]] associated with [[Ehlers-Danlos syndrome]].
This gene localizes to the major histocompatibility complex ([[major histocompatibility complex|MHC]]) class III region on chromosome 6. The structure of this gene is unusual in that it overlaps the [[CREBL1]] and [[21-Hydroxylase|CYP21A2]] genes at its 5' and 3' ends, respectively.<ref name="entrez">{{cite web | title = Entrez Gene: tenascin XB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7148| accessdate = }}</ref>


{{WH}}
== Function ==
{{WikiDoc Sources}}
 
This gene encodes a member of the tenascin family of [[extracellular matrix]] glycoproteins. The tenascins have anti-adhesive effects, as opposed to [[fibronectin]] which is adhesive. This protein is thought to function in matrix maturation during wound healing.<ref name="entrez"/>
 
== Clinical significance ==
 
Deficiency causes one of the types of [[Ehlers-Danlos syndrome]] where collagen density is reduced and elastic fibers are fragmentated.<ref>{{cite journal | last1 = Zweers | first1 = MC | last2 = Schalkwijk | first2 = J | last3 = Van Kuppevelt | first3 = TH | last4 = Van Vlijmen-Willems | first4 = IM | last5 = Bergers | first5 = M | last6 = Lethias | first6 = C | last7 = Lamme | first7 = EN | title = Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components | journal = Cell and Tissue Research | volume = 319 | issue = 2 | pages = 279–87 | year = 2005 | pmid = 15558324 | doi = 10.1007/s00441-004-1011-6}}</ref>
 
==References==
{{Reflist}}
 
==Further reading==
{{refbegin | 2}}
*{{cite journal  |author=Goepel C |title=Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse. |journal=Acta Histochem. |volume=110 |issue= 3 |pages= 204–9 |year= 2008 |pmid= 18155129 |doi= 10.1016/j.acthis.2007.10.014 }}
*{{cite journal  |vauthors=Yuan Y, Nymoen DA, Stavnes HT, etal |title=Tenascin-X is a novel diagnostic marker of malignant mesothelioma. |journal=Am. J. Surg. Pathol. |volume=33 |issue= 11 |pages= 1673–82 |year= 2009 |pmid= 19738457  |pmc=2783994 |doi= 10.1097/PAS.0b013e3181b6bde3 }}
*{{cite journal  |vauthors=Egging D, van Vlijmen-Willems I, van Tongeren T, etal |title=Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition. |journal=Connect. Tissue Res. |volume=48 |issue= 2 |pages= 93–8 |year= 2007 |pmid= 17453911 |doi= 10.1080/03008200601166160 }}
*{{cite journal  |vauthors=Egging DF, van Vlijmen-Willems I, Choi J, etal |title=Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice. |journal=Cell Tissue Res. |volume=332 |issue= 3 |pages= 523–32 |year= 2008 |pmid= 18335242  |pmc=2386751 |doi= 10.1007/s00441-008-0591-y }}
*{{cite journal  |vauthors=Kato A, Endo T, Abiko S, etal |title=Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. |journal=Exp. Cell Res. |volume=314 |issue= 14 |pages= 2661–73 |year= 2008 |pmid= 18588874 |doi= 10.1016/j.yexcr.2008.05.019 }}
*{{cite journal  |vauthors=Bristow J, Carey W, Egging D, Schalkwijk J |title=Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome. |journal=American Journal of Medical Genetics |volume=139C |issue= 1 |pages= 24–30 |year= 2005 |pmid= 16278880 |doi= 10.1002/ajmg.c.30071 }}
*{{cite journal  |vauthors=Fellay J, Ge D, Shianna KV, etal |editor1-last=McCarthy  |editor1-first=Mark I. |title=Common genetic variation and the control of HIV-1 in humans. |journal=PLoS Genet. |volume=5 |issue= 12 |pages= e1000791 |year= 2009 |pmid= 20041166  |pmc=2791220 |doi= 10.1371/journal.pgen.1000791 }}
*{{cite journal  |vauthors=Kamatani Y, Matsuda K, Ohishi T, etal |title=Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. |journal=J. Hum. Genet. |volume=53 |issue= 1 |pages= 64–73 |year= 2008 |pmid= 18058064 |doi= 10.1007/s10038-007-0219-1 }}
*{{cite journal  |vauthors=Valdes AM, Thomson G |title=Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.  |series=11 |journal=Diabetes Obes Metab |volume=Suppl 1 |issue=  |pages= 46–52 |year= 2009 |pmid= 19143814  |pmc=2755069 |doi= 10.1111/j.1463-1326.2008.01002.x }}
*{{cite journal  |author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213–30 |year= 1998 |pmid= 10072631 |doi=10.1159/000019075  }}
*{{cite journal  |vauthors=Endo T, Ariga H, Matsumoto K |title=Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5. |journal=Mol. Cell. Biochem. |volume=320 |issue= 1-2 |pages= 53–66 |year= 2009 |pmid= 18679583 |doi= 10.1007/s11010-008-9898-y }}
*{{cite journal  |vauthors=Sovio U, Bennett AJ, Millwood IY, etal |editor1-last=Gibson  |editor1-first=Greg |title=Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. |journal=PLoS Genet. |volume=5 |issue= 3 |pages= e1000409 |year= 2009 |pmid= 19266077  |pmc=2646138 |doi= 10.1371/journal.pgen.1000409 }}
*{{cite journal  |vauthors=Araújo VC, Furuse C, Cury PR, etal |title=Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=16 |issue= 1 |pages= 48–53 |year= 2008 |pmid= 18091320 |doi= 10.1097/PAI.0b013e31802eff1c }}
*{{cite journal  |vauthors=Gudbjartsson DF, Walters GB, Thorleifsson G, etal |title=Many sequence variants affecting diversity of adult human height. |journal=Nat. Genet. |volume=40 |issue= 5 |pages= 609–15 |year= 2008 |pmid= 18391951 |doi= 10.1038/ng.122 }}
*{{cite journal  |vauthors=Barcellos LF, May SL, Ramsay PP, etal |editor1-last=Roopenian  |editor1-first=Derry C. |title=High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. |journal=PLoS Genet. |volume=5 |issue= 10 |pages= e1000696 |year= 2009 |pmid= 19851445  |pmc=2758598 |doi= 10.1371/journal.pgen.1000696 }}
*{{cite journal  |vauthors=McKinnon E, Morahan G, Nolan D, etal |title=Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.  |volume=11 |journal=Diabetes Obes Metab |issue= Suppl 1 |pages= 92–100 |year= 2009 |pmid= 19143821  |pmc=2755510 |doi= 10.1111/j.1463-1326.2008.01009.x }}
*{{cite journal  |vauthors=Chapuis J, Hot D, Hansmannel F, etal |title=Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. |journal=Mol. Psychiatry |volume=14 |issue= 11 |pages= 1004–16 |year= 2009 |pmid= 19204726  |pmc=2860783 |doi= 10.1038/mp.2009.10 }}
*{{cite journal  |vauthors=Vignal C, Bansal AT, Balding DJ, etal |title=Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. |journal=Arthritis Rheum. |volume=60 |issue= 1 |pages= 53–62 |year= 2009 |pmid= 19116923 |doi= 10.1002/art.24138 }}
*{{cite journal  |vauthors=Buysschaert ID, Grulois V, Eloy P, etal |title=Genetic evidence for a role of IL33 in nasal polyposis. |journal=Allergy |volume=65 |issue= 5 |pages= 616–22 |year= 2010 |pmid= 19860791 |doi= 10.1111/j.1398-9995.2009.02227.x }}
*{{cite journal  |vauthors=Gudbjartsson DF, Bjornsdottir US, Halapi E, etal |title=Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. |journal=Nat. Genet. |volume=41 |issue= 3 |pages= 342–7 |year= 2009 |pmid= 19198610 |doi= 10.1038/ng.323 }}
{{refend}}
 
==External links==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=eds3  GeneReviews/NCBI/NIH/UW entry on Ehlers-Danlos Syndrome, Hypermobility Type]
 
{{NLM content}}
{{PDB Gallery|geneid=7148}}
{{Fibrous proteins}}
 
[[Category:Tenascins]]
 
 
{{gene-6-stub}}

Revision as of 03:35, 2 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

A member of the tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB gene.[1]

Gene

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.[2]

Function

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing.[2]

Clinical significance

Deficiency causes one of the types of Ehlers-Danlos syndrome where collagen density is reduced and elastic fibers are fragmentated.[3]

References

  1. ↑ Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
  2. ↑ 2.0 2.1 "Entrez Gene: tenascin XB".
  3. ↑ Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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