MAP3K7IP2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitogen-activated protein kinase kinase kinase 7-interacting protein 2''' is an [[enzyme]] that in humans is encoded by the ''MAP3K7IP2'' [[gene]].<ref name="pmid9872452">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 | date = Apr 1999 | pmid = 9872452 | pmc =  | doi = 10.1093/dnares/5.5.277 }}</ref><ref name="pmid10882101">{{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol Cell | volume = 5 | issue = 4 | pages = 649–58 | date = Jul 2000 | pmid = 10882101 | pmc =  | doi = 10.1016/S1097-2765(00)80244-0 }}</ref><ref name="entrez_ 23118">{{cite web | title = Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene is an activator of [[MAP3K7]]/[[MAP3K7|TAK1]], which is required for the [[Interleukin 1|IL-1]] induced activation of [[NF-κB|nuclear factor kappaB]] and [[MAPK8]]/[[JNK]]. This protein forms a kinase complex with [[TRAF6]], [[MAP3K7]] and [[MAP3K7IP1|TAB1]], thus serves as an adaptor linking [[MAP3K7]] and [[TRAF6]]. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by [[TNFSF11]]/[[RANKL]] through the activation of the receptor activator of NF-kappB ([[TNFRSF11A]]/[[RANK]]), which may regulate the development and function of [[osteoclasts]].<ref name="entrez_ 23118"/> Mutations in MAP3K7IP2 have been associated with human congenital heart defects.<ref name="pmid20493459">{{cite journal | vauthors = Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA | title = Haploinsufficiency of TAB2 causes congenital heart defects in humans. | journal = Am J Hum Genet | volume = 86 | issue = 6 | pages = 839–49 | year = 2010 | pmid = 20493459 | pmc = 3032066 | doi = 10.1016/j.ajhg.2010.04.011 }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_MAP3K7IP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dae.
| PDB = {{PDB2|2dae}}
| Name = Mitogen-activated protein kinase kinase kinase 7 interacting protein 2
| HGNCid = 17075
| Symbol = MAP3K7IP2
| AltSymbols =; FLJ21885; KIAA0733; TAB2
| OMIM = 605101
| ECnumber = 
| Homologene = 9019
| MGIid = 1915902
| GeneAtlas_image1 = PBB_GE_MAP3K7IP2_210284_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAP3K7IP2_212184_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23118
    | Hs_Ensembl = ENSG00000055208
    | Hs_RefseqProtein = NP_055908
    | Hs_RefseqmRNA = NM_015093
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 149680756
    | Hs_GenLoc_end = 149774442
    | Hs_Uniprot = Q9NYJ8
    | Mm_EntrezGene = 68652
    | Mm_Ensembl = ENSMUSG00000015755
    | Mm_RefseqmRNA = NM_138667
    | Mm_RefseqProtein = NP_619608
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 7596309
    | Mm_GenLoc_end = 7615052
    | Mm_Uniprot = Q99K90
  }}
}}
'''Mitogen-activated protein kinase kinase kinase 7 interacting protein 2''', also known as '''MAP3K7IP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118| accessdate = }}</ref>
}}


==References==
MAP3K7IP2 has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
{{div col|colwidth=20em}}
==Further reading==
* [[HDAC3]],<ref name = pmid12150997/>
* [[MAP3K7IP1]],<ref name = pmid10882101/><ref name = pmid14743216>{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}</ref><ref name = pmid14670075>{{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | date = Feb 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}</ref>
* [[MAP3K7IP3]],<ref name = pmid14633987/>
* [[MAP3K7]],<ref name = pmid10882101/><ref name = pmid14670075/><ref name = pmid11259596/>
* [[NFKB1]],<ref name = pmid12150997>{{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | date = Jul 2002 | pmid = 12150997 | doi =  10.1016/S0092-8674(02)00809-7}}</ref>
* [[NUMBL]],<ref name = pmid18299187>{{cite journal | vauthors = Ma Q, Zhou L, Shi H, Huo K | title = NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation | journal = Cell. Signal. | volume = 20 | issue = 6 | pages = 1044–51 | date = Jun 2008 | pmid = 18299187 | doi = 10.1016/j.cellsig.2008.01.015 }}</ref>
* [[Nuclear receptor co-repressor 1]],<ref name = pmid12150997/>
* [[TRAF2]],<ref name = pmid10882101 /><ref name = pmid19150425>{{cite journal | vauthors = Li S, Wang L, Dorf ME | title = PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination | journal = Mol. Cell | volume = 33 | issue = 1 | pages = 30–42 | date = Jan 2009 | pmid = 19150425 | pmc = 2643372 | doi = 10.1016/j.molcel.2008.11.023 }}</ref>  and
* [[TRAF6]].<ref name = pmid10882101/><ref name = pmid14633987>{{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | date = Dec 2003 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}</ref><ref name = pmid11259596>{{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | date = Apr 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}</ref><ref name = pmid18299187/><ref name = pmid19112497>{{cite journal | vauthors = Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y | title = TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL | journal = PLoS ONE | volume = 3 | issue = 12 | pages = e4064 | pmid = 19112497 | pmc = 2603309 | doi = 10.1371/journal.pone.0004064 | editor1-last = Unutmaz | editor1-first = Derya }}</ref><ref name = pmid18180283>{{cite journal | vauthors = Windheim M, Stafford M, Peggie M, Cohen P | title = Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase | journal = Mol. Cell. Biol. | volume = 28 | issue = 5 | pages = 1783–91 | date = Mar 2008 | pmid = 18180283 | pmc = 2258775 | doi = 10.1128/MCB.02380-06 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K | title = TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | journal = Science | volume = 272 | issue = 5265 | pages = 1179–82 | year = 1996 | pmid = 8638164 | doi = 10.1126/science.272.5265.1179 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | year = 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}
*{{cite journal | author=Shibuya H, Yamaguchi K, Shirakabe K, ''et al.'' |title=TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. |journal=Science |volume=272 |issue= 5265 |pages= 1179-82 |year= 1996 |pmid= 8638164 |doi= }}
* {{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 41661–7 | year = 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N | title = Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 | journal = Mol. Cell. Biol. | volume = 22 | issue = 4 | pages = 992–1000 | year = 2002 | pmid = 11809792 | pmc = 134634 | doi = 10.1128/MCB.22.4.992-1000.2002 }}
*{{cite journal  | author=Takaesu G, Kishida S, Hiyama A, ''et al.'' |title=TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. |journal=Mol. Cell |volume=5 |issue= 4 |pages= 649-58 |year= 2000 |pmid= 10882101 |doi= }}
* {{cite journal | vauthors = Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ | title = ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 34 | pages = 30454–62 | year = 2002 | pmid = 12048196 | doi = 10.1074/jbc.M203312200 }}
*{{cite journal | author=Takaesu G, Ninomiya-Tsuji J, Kishida S, ''et al.'' |title=Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. |journal=Mol. Cell. Biol. |volume=21 |issue= 7 |pages= 2475-84 |year= 2001 |pmid= 11259596 |doi= 10.1128/MCB.21.7.2475-2484.2001 }}
* {{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150997 | doi = 10.1016/S0092-8674(02)00809-7 }}
*{{cite journal | author=Qian Y, Commane M, Ninomiya-Tsuji J, ''et al.'' |title=IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41661-7 |year= 2001 |pmid= 11518704 |doi= 10.1074/jbc.M102262200 }}
* {{cite journal | vauthors = Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X | title = Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol | journal = Mol. Cell. Biol. | volume = 22 | issue = 20 | pages = 7158–67 | year = 2002 | pmid = 12242293 | pmc = 139807 | doi = 10.1128/MCB.22.20.7158-7167.2002 }}
*{{cite journal | author=Mizukami J, Takaesu G, Akatsuka H, ''et al.'' |title=Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. |journal=Mol. Cell. Biol. |volume=22 |issue= 4 |pages= 992-1000 |year= 2002 |pmid= 11809792 |doi= }}
* {{cite journal | vauthors = Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X | title = Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 16713–9 | year = 2003 | pmid = 12609980 | doi = 10.1074/jbc.M300562200 }}
*{{cite journal | author=Sanna MG, da Silva Correia J, Luo Y, ''et al.'' |title=ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30454-62 |year= 2002 |pmid= 12048196 |doi= 10.1074/jbc.M203312200 }}
* {{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | year = 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}
*{{cite journal | author=Baek SH, Ohgi KA, Rose DW, ''et al.'' |title=Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. |journal=Cell |volume=110 |issue= 1 |pages= 55-67 |year= 2002 |pmid= 12150997 |doi=  }}
* {{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | year = 2004 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}
*{{cite journal  | author=Jiang Z, Ninomiya-Tsuji J, Qian Y, ''et al.'' |title=Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 7158-67 |year= 2002 |pmid= 12242293 |doi= }}
* {{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | year = 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Jiang Z, Zamanian-Daryoush M, Nie H, ''et al.'' |title=Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16713-9 |year= 2003 |pmid= 12609980 |doi= 10.1074/jbc.M300562200 }}
* {{cite journal | vauthors = Owerbach D, Piña L, Gabbay KH | title = A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes | journal = Diabetes | volume = 53 | issue = 7 | pages = 1890–3 | year = 2004 | pmid = 15220215 | doi = 10.2337/diabetes.53.7.1890 }}
*{{cite journal | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307-18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
* {{cite journal | vauthors = Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ | title = TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains | journal = Mol. Cell | volume = 15 | issue = 4 | pages = 535–48 | year = 2004 | pmid = 15327770 | doi = 10.1016/j.molcel.2004.08.008 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Ishitani T, Takaesu G, Ninomiya-Tsuji J, ''et al.'' |title=Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6277-88 |year= 2004 |pmid= 14633987 |doi= 10.1093/emboj/cdg605 }}
*{{cite journal  | author=Cheung PC, Nebreda AR, Cohen P |title=TAB3, a new binding partner of the protein kinase TAK1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 27-34 |year= 2004 |pmid= 14670075 |doi= 10.1042/BJ20031794 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Owerbach D, Piña L, Gabbay KH |title=A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. |journal=Diabetes |volume=53 |issue= 7 |pages= 1890-3 |year= 2004 |pmid= 15220215 |doi=  }}
*{{cite journal  | author=Kanayama A, Seth RB, Sun L, ''et al.'' |title=TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 535-48 |year= 2004 |pmid= 15327770 |doi= 10.1016/j.molcel.2004.08.008 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=23118}}
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Latest revision as of 06:06, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.[1][2][3]

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.[3] Mutations in MAP3K7IP2 have been associated with human congenital heart defects.[4]

Interactions

MAP3K7IP2 has been shown to interact with:

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (Jul 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol Cell. 5 (4): 649–58. doi:10.1016/S1097-2765(00)80244-0. PMID 10882101.
  3. ↑ 3.0 3.1 "Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2".
  4. ↑ Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA (2010). "Haploinsufficiency of TAB2 causes congenital heart defects in humans". Am J Hum Genet. 86 (6): 839–49. doi:10.1016/j.ajhg.2010.04.011. PMC 3032066. PMID 20493459.
  5. ↑ 5.0 5.1 5.2 Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (Jul 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell. 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. PMID 12150997.
  6. ↑ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  7. ↑ 7.0 7.1 Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
  8. ↑ 8.0 8.1 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Dec 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
  9. ↑ 9.0 9.1 Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (Apr 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Mol. Cell. Biol. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
  10. ↑ 10.0 10.1 Ma Q, Zhou L, Shi H, Huo K (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6): 1044–51. doi:10.1016/j.cellsig.2008.01.015. PMID 18299187.
  11. ↑ Li S, Wang L, Dorf ME (Jan 2009). "PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination". Mol. Cell. 33 (1): 30–42. doi:10.1016/j.molcel.2008.11.023. PMC 2643372. PMID 19150425.
  12. ↑ Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y. Unutmaz D, ed. "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL". PLoS ONE. 3 (12): e4064. doi:10.1371/journal.pone.0004064. PMC 2603309. PMID 19112497.
  13. ↑ Windheim M, Stafford M, Peggie M, Cohen P (Mar 2008). "Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase". Mol. Cell. Biol. 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283.

Further reading

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