PLAGL1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein PLAGL1''' is a [[protein]] that in humans is encoded by the ''PLAGL1'' [[gene]].<ref name="pmid9722527">{{cite journal | vauthors = Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ | title = Transcriptional activation capacity of the novel PLAG family of zinc finger proteins | journal = J. Biol. Chem. | volume = 273 | issue = 36 | pages = 23026–32  | date = Oct 1998 | pmid = 9722527 | pmc =  | doi = 10.1074/jbc.273.36.23026 }}</ref><ref name="pmid9671765">{{cite journal | vauthors = Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L | title = hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 15 | pages = 8835–40  | date = Aug 1998 | pmid = 9671765 | pmc = 21163 | doi = 10.1073/pnas.95.15.8835 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5325| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pleiomorphic adenoma gene-like 1
| HGNCid = 9046
| Symbol = PLAGL1
| AltSymbols =; DKFZp781P1017; LOT1; MGC126275; MGC126276; ZAC; ZAC1
| OMIM = 603044
| ECnumber = 
| Homologene = 31401
| MGIid = 
| GeneAtlas_image1 = PBB_GE_PLAGL1_207002_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLAGL1_207943_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PLAGL1_209318_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5325
    | Hs_Ensembl = ENSG00000118495
    | Hs_RefseqProtein = NP_001074420
    | Hs_RefseqmRNA = NM_001080951
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 144303130
    | Hs_GenLoc_end = 144371246
    | Hs_Uniprot = Q9UM63
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Pleiomorphic adenoma gene-like 1''', also known as '''PLAGL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5325| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5325| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLAGL1 has been shown to [[Protein-protein interaction|interact]] with [[P53]].<ref name=pmid11360197>{{cite journal | vauthors = Huang SM, Schönthal AH, Stallcup MR | title = Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 | journal = Oncogene | volume = 20 | issue = 17 | pages = 2134–43  | date = Apr 2001 | pmid = 11360197 | doi = 10.1038/sj.onc.1204298 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Vernon M | title = Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications | journal = J Deaf Stud Deaf Educ | volume = 10 | issue = 3 | pages = 225–31 | year = 2005 | pmid = 15888725 | doi = 10.1093/deafed/eni024 }}
| citations =
* {{cite journal | vauthors = Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC | title = Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors | journal = Oncogene | volume = 14 | issue = 16 | pages = 1973–9 | year = 1997 | pmid = 9150364 | doi = 10.1038/sj.onc.1201034 }}
*{{cite journal | author=Vernon M |title=Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications. |journal=Journal of deaf studies and deaf education |volume=10 |issue= 3 |pages= 225-31 |year= 2005 |pmid= 15888725 |doi= 10.1093/deafed/eni024 }}
* {{cite journal | vauthors = Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC | title = Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells | journal = Cancer Res. | volume = 57 | issue = 10 | pages = 2029–34 | year = 1997 | pmid = 9158001 | doi =  }}
*{{cite journal | author=Abdollahi A, Roberts D, Godwin AK, ''et al.'' |title=Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. |journal=Oncogene |volume=14 |issue= 16 |pages= 1973-9 |year= 1997 |pmid= 9150364 |doi= 10.1038/sj.onc.1201034 }}
* {{cite journal | vauthors = Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L | title = Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain | journal = EMBO J. | volume = 16 | issue = 10 | pages = 2814–25 | year = 1997 | pmid = 9184226 | pmc = 1169890 | doi = 10.1093/emboj/16.10.2814 }}
*{{cite journal | author=Abdollahi A, Godwin AK, Miller PD, ''et al.'' |title=Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. |journal=Cancer Res. |volume=57 |issue= 10 |pages= 2029-34 |year= 1997 |pmid= 9158001 |doi=  }}
* {{cite journal | vauthors = Abdollahi A, Bao R, Hamilton TC | title = LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein | journal = Oncogene | volume = 18 | issue = 47 | pages = 6477–87 | year = 1999 | pmid = 10597250 | doi = 10.1038/sj.onc.1203067 }}
*{{cite journal | author=Spengler D, Villalba M, Hoffmann A, ''et al.'' |title=Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2814-25 |year= 1997 |pmid= 9184226 |doi= 10.1093/emboj/16.10.2814 }}
* {{cite journal | vauthors = Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y | title = The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes | journal = Hum. Mol. Genet. | volume = 9 | issue = 3 | pages = 453–60 | year = 2000 | pmid = 10655556 | doi = 10.1093/hmg/9.3.453 }}
*{{cite journal | author=Varrault A, Ciani E, Apiou F, ''et al.'' |title=hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8835-40 |year= 1998 |pmid= 9671765 |doi=  }}
* {{cite journal | vauthors = Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L | title = Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities | journal = Oncogene | volume = 20 | issue = 10 | pages = 1246–53 | year = 2001 | pmid = 11313869 | doi = 10.1038/sj.onc.1204237 }}
*{{cite journal  | author=Kas K, Voz ML, Hensen K, ''et al.'' |title=Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23026-32 |year= 1998 |pmid= 9722527 |doi=  }}
* {{cite journal | vauthors = Huang SM, Schönthal AH, Stallcup MR | title = Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 | journal = Oncogene | volume = 20 | issue = 17 | pages = 2134–43 | year = 2001 | pmid = 11360197 | doi = 10.1038/sj.onc.1204298 }}
*{{cite journal  | author=Abdollahi A, Bao R, Hamilton TC |title=LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein. |journal=Oncogene |volume=18 |issue= 47 |pages= 6477-87 |year= 2000 |pmid= 10597250 |doi= 10.1038/sj.onc.1203067 }}
* {{cite journal | vauthors = Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO | title = Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus | journal = Hum. Genet. | volume = 110 | issue = 2 | pages = 139–44 | year = 2002 | pmid = 11935319 | doi = 10.1007/s00439-001-0671-5 }}
*{{cite journal | author=Kamiya M, Judson H, Okazaki Y, ''et al.'' |title=The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes. |journal=Hum. Mol. Genet. |volume=9 |issue= 3 |pages= 453-60 |year= 2000 |pmid= 10655556 |doi= }}
* {{cite journal | vauthors = Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC | title = LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6041–9 | year = 2003 | pmid = 12473647 | doi = 10.1074/jbc.M210361200 }}
*{{cite journal | author=Bilanges B, Varrault A, Mazumdar A, ''et al.'' |title=Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities. |journal=Oncogene |volume=20 |issue= 10 |pages= 1246-53 |year= 2001 |pmid= 11313869 |doi= 10.1038/sj.onc.1204237 }}
* {{cite journal | vauthors = Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D | title = Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding | journal = Mol. Cell. Biol. | volume = 23 | issue = 3 | pages = 988–1003 | year = 2003 | pmid = 12529403 | pmc = 140694 | doi = 10.1128/MCB.23.3.988-1003.2003 }}
*{{cite journal | author=Huang SM, Schönthal AH, Stallcup MR |title=Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. |journal=Oncogene |volume=20 |issue= 17 |pages= 2134-43 |year= 2001 |pmid= 11360197 |doi= 10.1038/sj.onc.1204298 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Mackay DJ, Coupe AM, Shield JP, ''et al.'' |title=Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 139-44 |year= 2002 |pmid= 11935319 |doi= 10.1007/s00439-001-0671-5 }}
* {{cite journal | vauthors = Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G | title = Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM | journal = J. Clin. Invest. | volume = 114 | issue = 3 | pages = 339–48 | year = 2004 | pmid = 15286800 | pmc = 484972 | doi = 10.1172/JCI19876 }}
*{{cite journal | author=Abdollahi A, Pisarcik D, Roberts D, ''et al.'' |title=LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6041-9 |year= 2003 |pmid= 12473647 |doi= 10.1074/jbc.M210361200 }}
* {{cite journal | vauthors = Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A | title = Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer | journal = Gynecol. Oncol. | volume = 95 | issue = 3 | pages = 449–55 | year = 2004 | pmid = 15581945 | doi = 10.1016/j.ygyno.2004.08.051 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C | title = Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome | journal = Diabetologia | volume = 47 | issue = 12 | pages = 2160–7 | year = 2004 | pmid = 15592663 | doi = 10.1007/s00125-004-1576-3 }}
*{{cite journal  | author=Hoffmann A, Ciani E, Boeckardt J, ''et al.'' |title=Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding. |journal=Mol. Cell. Biol. |volume=23 |issue= 3 |pages= 988-1003 |year= 2003 |pmid= 12529403 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Ma D, Shield JP, Dean W, ''et al.'' |title=Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. |journal=J. Clin. Invest. |volume=114 |issue= 3 |pages= 339-48 |year= 2004 |pmid= 15286800 |doi= 10.1172/JCI200419876 }}
*{{cite journal | author=Cvetkovic D, Pisarcik D, Lee C, ''et al.'' |title=Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. |journal=Gynecol. Oncol. |volume=95 |issue= 3 |pages= 449-55 |year= 2005 |pmid= 15581945 |doi= 10.1016/j.ygyno.2004.08.051 }}
*{{cite journal | author=Mitchell J, Punthakee Z, Lo B, ''et al.'' |title=Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome. |journal=Diabetologia |volume=47 |issue= 12 |pages= 2160-7 |year= 2005 |pmid= 15592663 |doi= 10.1007/s00125-004-1576-3 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:15, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[1][2][3]

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[3]

Interactions

PLAGL1 has been shown to interact with P53.[4]

References

  1. ↑ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
  2. ↑ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
  3. ↑ 3.0 3.1 "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
  4. ↑ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.

Further reading


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