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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Insulin-like growth factor-binding protein 1''' (IBP-1) also known as '''placental protein 12''' (PP12) is a [[protein]] that in humans is encoded by the ''IGFBP1'' [[gene]].<ref name="pmid2461294">{{cite journal |vauthors=Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL | title = Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1) | journal = EMBO J | volume = 7 | issue = 8 | pages = 2417–23 |date=Jan 1989 | pmid = 2461294 | pmc = 457109 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3484| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_IGFBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zt3.
| PDB = {{PDB2|1zt3}}, {{PDB2|1zt5}}, {{PDB2|2dsq}}
| Name = Insulin-like growth factor binding protein 1
| HGNCid = 5469
| Symbol = IGFBP1
| AltSymbols =; IBP1; AFBP; IGF-BP25; PP12; hIGFBP-1
| OMIM = 146730
| ECnumber = 
| Homologene = 498
| MGIid = 96436
| GeneAtlas_image1 = PBB_GE_IGFBP1_205302_at_tn.png
| Function = {{GNF_GO|id=GO:0005520 |text = insulin-like growth factor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3484
    | Hs_Ensembl = ENSG00000146678
    | Hs_RefseqProtein = NP_000587
    | Hs_RefseqmRNA = NM_000596
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 45894484
    | Hs_GenLoc_end = 45899791
    | Hs_Uniprot = P08833
    | Mm_EntrezGene = 16006
    | Mm_Ensembl = ENSMUSG00000020429
    | Mm_RefseqmRNA = NM_008341
    | Mm_RefseqProtein = NP_032367
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 7097782
    | Mm_GenLoc_end = 7102541
    | Mm_Uniprot = Q5SVY8
  }}
}}
'''Insulin-like growth factor binding protein 1''', also known as '''IGFBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3484| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[Insulin-like growth factor-binding protein]] (IGFBP) family and encodes a protein with an IGFBP domain and a type-I [[thyroglobulin domain]]. The protein binds both [[insulin-like growth factor]]s (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3484| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Rajaram S, Baylink DJ, Mohan S |title=Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. |journal=Endocr. Rev. |volume=18 |issue= 6 |pages= 801–31 |year= 1998 |pmid= 9408744 |doi=10.1210/er.18.6.801 }}
| citations =
*{{cite journal  |vauthors=Ferry RJ, Cerri RW, Cohen P |title=Insulin-like growth factor binding proteins: new proteins, new functions. |journal=Horm. Res. |volume=51 |issue= 2 |pages= 53–67 |year= 1999 |pmid= 10352394 |doi=10.1159/000023315 }}
*{{cite journal  | author=Rajaram S, Baylink DJ, Mohan S |title=Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. |journal=Endocr. Rev. |volume=18 |issue= 6 |pages= 801-31 |year= 1998 |pmid= 9408744 |doi=  }}
*{{cite journal  |vauthors=Firth SM, Baxter RC |title=Cellular actions of the insulin-like growth factor binding proteins. |journal=Endocr. Rev. |volume=23 |issue= 6 |pages= 824–54 |year= 2003 |pmid= 12466191 |doi=10.1210/er.2001-0033  }}
*{{cite journal  | author=Ferry RJ, Cerri RW, Cohen P |title=Insulin-like growth factor binding proteins: new proteins, new functions. |journal=Horm. Res. |volume=51 |issue= 2 |pages= 53-67 |year= 1999 |pmid= 10352394 |doi=  }}
*{{cite journal  |vauthors=Wood AW, Duan C, Bern HA |title=Insulin-like growth factor signaling in fish. |journal=Int. Rev. Cytol. |volume=243 |issue=  |pages= 215–85 |year= 2005 |pmid= 15797461 |doi= 10.1016/S0074-7696(05)43004-1 }}
*{{cite journal  | author=Firth SM, Baxter RC |title=Cellular actions of the insulin-like growth factor binding proteins. |journal=Endocr. Rev. |volume=23 |issue= 6 |pages= 824-54 |year= 2003 |pmid= 12466191 |doi= }}
*{{cite journal   |vauthors=Ehrenborg E, Larsson C, Stern I, etal |title=Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. |journal=Genomics |volume=12 |issue= 3 |pages= 497–502 |year= 1992 |pmid= 1373120 |doi=10.1016/0888-7543(92)90440-4 }}
*{{cite journal  | author=Wood AW, Duan C, Bern HA |title=Insulin-like growth factor signaling in fish. |journal=Int. Rev. Cytol. |volume=243 |issue=  |pages= 215-85 |year= 2005 |pmid= 15797461 |doi= 10.1016/S0074-7696(05)43004-1 }}
*{{cite journal   |vauthors=Ekstrand J, Ehrenborg E, Stern I, etal |title=The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12. |journal=Genomics |volume=6 |issue= 3 |pages= 413–8 |year= 1990 |pmid= 1691735 |doi=10.1016/0888-7543(90)90470-F  }}
*{{cite journal | author=Ehrenborg E, Larsson C, Stern I, ''et al.'' |title=Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. |journal=Genomics |volume=12 |issue= 3 |pages= 497-502 |year= 1992 |pmid= 1373120 |doi=  }}
*{{cite journal  |vauthors=Suwanichkul A, Cubbage ML, Powell DR |title=The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1. |journal=J. Biol. Chem. |volume=265 |issue= 34 |pages= 21185–93 |year= 1991 |pmid= 1701175 |doi=  }}
*{{cite journal | author=Ekstrand J, Ehrenborg E, Stern I, ''et al.'' |title=The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12. |journal=Genomics |volume=6 |issue= 3 |pages= 413-8 |year= 1990 |pmid= 1691735 |doi= }}
*{{cite journal   |vauthors=Brinkman A, Kortleve DJ, Schuller AG, etal |title=Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 264–8 |year= 1991 |pmid= 1718783 |doi=10.1016/0014-5793(91)81298-M }}
*{{cite journal  | author=Suwanichkul A, Cubbage ML, Powell DR |title=The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1. |journal=J. Biol. Chem. |volume=265 |issue= 34 |pages= 21185-93 |year= 1991 |pmid= 1701175 |doi=  }}
*{{cite journal   |vauthors=Brewer MT, Stetler GL, Squires CH, etal |title=Cloning, characterization, and expression of a human insulin-like growth factor binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=152 |issue= 3 |pages= 1289–97 |year= 1988 |pmid= 2454104 |doi=10.1016/S0006-291X(88)80425-X  }}
*{{cite journal | author=Brinkman A, Kortleve DJ, Schuller AG, ''et al.'' |title=Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 264-8 |year= 1991 |pmid= 1718783 |doi=  }}
*{{cite journal   |vauthors=Julkunen M, Koistinen R, Aalto-Setälä K, etal |title=Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. |journal=FEBS Lett. |volume=236 |issue= 2 |pages= 295–302 |year= 1988 |pmid= 2457513 |doi=10.1016/0014-5793(88)80041-3 }}
*{{cite journal | author=Brewer MT, Stetler GL, Squires CH, ''et al.'' |title=Cloning, characterization, and expression of a human insulin-like growth factor binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=152 |issue= 3 |pages= 1289-97 |year= 1988 |pmid= 2454104 |doi= }}
*{{cite journal   |vauthors=Lee YL, Hintz RL, James PM, etal |title=Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors. |journal=Mol. Endocrinol. |volume=2 |issue= 5 |pages= 404–11 |year= 1988 |pmid= 2458522 |doi=10.1210/mend-2-5-404  }}
*{{cite journal | author=Julkunen M, Koistinen R, Aalto-Setälä K, ''et al.'' |title=Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. |journal=FEBS Lett. |volume=236 |issue= 2 |pages= 295-302 |year= 1988 |pmid= 2457513 |doi=  }}
*{{cite journal   |vauthors=Luthman H, Söderling-Barros J, Persson B, etal |title=Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning. |journal=Eur. J. Biochem. |volume=180 |issue= 2 |pages= 259–65 |year= 1989 |pmid= 2466665 |doi=10.1111/j.1432-1033.1989.tb14641.x  }}
*{{cite journal | author=Lee YL, Hintz RL, James PM, ''et al.'' |title=Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors. |journal=Mol. Endocrinol. |volume=2 |issue= 5 |pages= 404-11 |year= 1988 |pmid= 2458522 |doi= }}
*{{cite journal  |vauthors=Cubbage ML, Suwanichkul A, Powell DR |title=Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein. |journal=Mol. Endocrinol. |volume=3 |issue= 5 |pages= 846–51 |year= 1989 |pmid= 2474129 |doi=10.1210/mend-3-5-846 }}
*{{cite journal | author=Brinkman A, Groffen C, Kortleve DJ, ''et al.'' |title=Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). |journal=EMBO J. |volume=7 |issue= 8 |pages= 2417-23 |year= 1989 |pmid= 2461294 |doi= }}
*{{cite journal   |vauthors=Alitalo T, Kontula K, Koistinen R, etal |title=The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism. |journal=Hum. Genet. |volume=83 |issue= 4 |pages= 335–8 |year= 1989 |pmid= 2478445 |doi=10.1007/BF00291377 }}
*{{cite journal  | author=Luthman H, Söderling-Barros J, Persson B, ''et al.'' |title=Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning. |journal=Eur. J. Biochem. |volume=180 |issue= 2 |pages= 259-65 |year= 1989 |pmid= 2466665 |doi=  }}
*{{cite journal  |vauthors=Brinkman A, Groffen CA, Kortleve DJ, Drop SL |title=Organization of the gene encoding the insulin-like growth factor binding protein IBP-1. |journal=Biochem. Biophys. Res. Commun. |volume=157 |issue= 3 |pages= 898–907 |year= 1989 |pmid= 2849945 |doi=10.1016/S0006-291X(88)80959-8 }}
*{{cite journal | author=Cubbage ML, Suwanichkul A, Powell DR |title=Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein. |journal=Mol. Endocrinol. |volume=3 |issue= 5 |pages= 846-51 |year= 1989 |pmid= 2474129 |doi=  }}
*{{cite journal  |vauthors=Busby WH, Klapper DG, Clemmons DR |title=Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. |journal=J. Biol. Chem. |volume=263 |issue= 28 |pages= 14203–10 |year= 1988 |pmid= 2971653 |doi=  }}
*{{cite journal  | author=Alitalo T, Kontula K, Koistinen R, ''et al.'' |title=The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism. |journal=Hum. Genet. |volume=83 |issue= 4 |pages= 335-8 |year= 1989 |pmid= 2478445 |doi=  }}
*{{cite journal  |vauthors=Grundmann U, Nerlich C, Bohn H, Rein T |title=Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8711 |year= 1988 |pmid= 3419931 |doi=10.1093/nar/16.17.8711  | pmc=338590 }}
*{{cite journal  | author=Brinkman A, Groffen CA, Kortleve DJ, Drop SL |title=Organization of the gene encoding the insulin-like growth factor binding protein IBP-1. |journal=Biochem. Biophys. Res. Commun. |volume=157 |issue= 3 |pages= 898-907 |year= 1989 |pmid= 2849945 |doi=  }}
*{{cite journal   |vauthors=Jones JI, Gockerman A, Busby WH, etal |title=Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10553–7 |year= 1993 |pmid= 7504269 |doi=10.1073/pnas.90.22.10553  | pmc=47815 }}
*{{cite journal  | author=Busby WH, Klapper DG, Clemmons DR |title=Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. |journal=J. Biol. Chem. |volume=263 |issue= 28 |pages= 14203-10 |year= 1988 |pmid= 2971653 |doi=  }}
*{{cite journal   |vauthors=Jones JI, Busby WH, Wright G, etal |title=Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. |journal=J. Biol. Chem. |volume=268 |issue= 2 |pages= 1125–31 |year= 1993 |pmid= 7678248 |doi=  }}
*{{cite journal | author=Grundmann U, Nerlich C, Bohn H, Rein T |title=Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8711 |year= 1988 |pmid= 3419931 |doi= }}
*{{cite journal  | author=Jones JI, Gockerman A, Busby WH, ''et al.'' |title=Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10553-7 |year= 1993 |pmid= 7504269 |doi=  }}
*{{cite journal | author=Jones JI, Busby WH, Wright G, ''et al.'' |title=Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. |journal=J. Biol. Chem. |volume=268 |issue= 2 |pages= 1125-31 |year= 1993 |pmid= 7678248 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=3484}}
{{WikiDoc Sources}}
{{Carrier proteins}}
{{Growth factor receptor modulators}}
 
 
{{gene-7-stub}}

Latest revision as of 01:40, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.[1][2]

Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

References

  1. ↑ Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL (Jan 1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J. 7 (8): 2417–23. PMC 457109. PMID 2461294.
  2. ↑ 2.0 2.1 "Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1".

Further reading

  • Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744.
  • Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394.
  • Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
  • Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.
  • Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7". Genomics. 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120.
  • Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12". Genomics. 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735.
  • Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175.
  • Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783.
  • Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104.
  • Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513.
  • Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522.
  • Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665.
  • Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129.
  • Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445.
  • Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945.
  • Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653.
  • Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931.
  • Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269.
  • Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.


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