CPSF1: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
m (Bot: HTTP→HTTPS) |
||
| Line 1: | Line 1: | ||
< | {{Infobox_gene}} | ||
{{ | '''Cleavage and polyadenylation specificity factor subunit 1''' is a [[protein]] that in humans is encoded by the ''CPSF1'' [[gene]].<ref name="pmid7651824">{{cite journal | vauthors = Jenny A, Keller W | title = Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor | journal = Nucleic Acids Res | volume = 23 | issue = 14 | pages = 2629–35 |date=Sep 1995 | pmid = 7651824 | pmc = 307085 | doi =10.1093/nar/23.14.2629 }}</ref><ref name="pmid7590244">{{cite journal | vauthors = Murthy KG, Manley JL | title = The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation | journal = Genes Dev | volume = 9 | issue = 21 | pages = 2672–83 |date=Dec 1995 | pmid = 7590244 | pmc = | doi =10.1101/gad.9.21.2672 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29894| accessdate = }}</ref> | ||
| | |||
| | |||
| | |||
}} | |||
In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1, and located in the nucleus. CPSF1 recognizes the AAUAAA sequence leading to [[Polyadenylation|addition of poly(A)]] to the 3-prime end of the mRNA.<ref>{{cite journal|vauthors=Yang Q, Doublié S|title=Structural biology of poly(A) site definition|journal=Wiley Interdiscip Rev RNA|year=2011|volume=2|pages=723–747|pmid=21823232|doi=10.1002/wrna.88|issue=5|pmc=3153407}}</ref> | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
| Line 57: | Line 11: | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CPSF1}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Keller W, Bienroth S, Lang KM, Christofori G |title=Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA |journal=EMBO J. |volume=10 |issue= 13 |pages= 4241–9 |year= 1992 |pmid= 1756731 |doi= | pmc=453176 }} | ||
*{{cite journal | author= | *{{cite journal | author=Thuresson AC |title=Multiple forms of poly(A) polymerases in human cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 3 |pages= 979–83 |year= 1994 |pmid= 8302877 |doi=10.1073/pnas.91.3.979 | pmc=521437 |name-list-format=vanc| author2=Aström J | author3=Aström A | display-authors=3 | last4=Grönvik | first4=KO | last5=Virtanen | first5=A }} | ||
*{{cite journal | author=Schul W |title=The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA |journal=EMBO J. |volume=15 |issue= 11 |pages= 2883–92 |year= 1996 |pmid= 8654386 |doi= | pmc=450226 |name-list-format=vanc| author2=Groenhout B | author3=Koberna K | display-authors=3 | last4=Takagaki | first4=Y | last5=Jenny | first5=A | last6=Manders | first6=EM | last7=Raska | first7=I | last8=Van Driel | first8=R | last9=De Jong | first9=L }} | |||
*{{cite journal | author= | *{{cite journal | author=McCracken S |title=The C-terminal domain of RNA polymerase II couples mRNA processing to transcription |journal=Nature |volume=385 |issue= 6614 |pages= 357–61 |year= 1997 |pmid= 9002523 |doi= 10.1038/385357a0 |name-list-format=vanc| author2=Fong N | author3=Yankulov K | display-authors=3 | last4=Ballantyne | first4=Scott | last5=Pan | first5=Guohua | last6=Greenblatt | first6=Jack | last7=Patterson | first7=Scott D. | last8=Wickens | first8=Marvin | last9=Bentley | first9=David L. }} | ||
*{{cite journal | vauthors=Dantonel JC, Murthy KG, Manley JL, Tora L |title=Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA |journal=Nature |volume=389 |issue= 6649 |pages= 399–402 |year= 1997 |pmid= 9311784 |doi= 10.1038/38763 }} | |||
*{{cite journal | author=McCracken S | *{{cite journal | vauthors=Takagaki Y, Manley JL |title=Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000 | pmc=85326 }} | ||
*{{cite journal | author=de Vries H |title=Human pre-mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 | pmc=305781 |name-list-format=vanc| author2=Rüegsegger U | author3=Hübner W | display-authors=3 | last4=Friedlein | first4=A | last5=Langen | first5=H | last6=Keller | first6=W }} | |||
*{{cite journal | | *{{cite journal | vauthors=Samiotaki M, Balatsos NA, Courtis N, Tsiapalis CM |title=Assignment of the 160-kDa subunit of cleavage and polyadenylation specificity factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 234–5 |year= 2001 |pmid= 11124521 |doi=10.1159/000056776 }} | ||
*{{cite journal | | *{{cite journal | vauthors=McCracken S, Lambermon M, Blencowe BJ |title=SRm160 Splicing Coactivator Promotes Transcript 3′-End Cleavage |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 148–60 |year= 2002 |pmid= 11739730 |doi=10.1128/MCB.22.1.148-160.2002 | pmc=134228 }} | ||
*{{cite journal | author= | *{{cite journal | author=Maeda Y |title=Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients |journal=Int. J. Cancer |volume=99 |issue= 3 |pages= 409–17 |year= 2002 |pmid= 11992410 |doi= 10.1002/ijc.10377 |name-list-format=vanc| author2=Ito M | author3=Harashima N | display-authors=3 | last4=Nakatsura | first4=Tetsuya | last5=Hida | first5=Naoya | last6=Imai | first6=Nobue | last7=Sato | first7=Yuuji | last8=Shichijo | first8=Shigeki | last9=Todo | first9=Satoru }} | ||
*{{cite journal | vauthors=Holland L, Gauthier L, Bell-Rogers P, Yankulov K |title=Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme |journal=Eur. J. Biochem. |volume=269 |issue= 21 |pages= 5192–202 |year= 2002 |pmid= 12392551 |doi=10.1046/j.1432-1033.2002.03224.x }} | |||
*{{cite journal | | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | | *{{cite journal | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |name-list-format=vanc| author2=Semple JI | author3=Brown SE | display-authors=3 | last4=Counsell | first4=Damian | last5=Campbell | first5=R.Duncan | last6=Sanderson | first6=Christopher M }} | ||
*{{cite journal | author= | *{{cite journal | author=Kaufmann I |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase |journal=EMBO J. |volume=23 |issue= 3 |pages= 616–26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070 | pmc=1271804 |name-list-format=vanc| author2=Martin G | author3=Friedlein A | display-authors=3 | last4=Langen | first4=Hanno | last5=Keller | first5=Walter }} | ||
*{{cite journal | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |name-list-format=vanc| author2=Jedrychowski M | author3=Schwartz D | display-authors=3 | last4=Elias | first4=JE | last5=Villén | first5=J | last6=Li | first6=J | last7=Cohn | first7=MA | last8=Cantley | first8=LC | last9=Gygi | first9=SP }} | |||
*{{cite journal | | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{ | <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | ||
{{ | {{PBB_Controls | ||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{gene-8-stub}} | |||
Revision as of 10:00, 30 August 2017
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.[1][2][3]
In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1, and located in the nucleus. CPSF1 recognizes the AAUAAA sequence leading to addition of poly(A) to the 3-prime end of the mRNA.[4]
References
- ↑ Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085. PMID 7651824.
- ↑ Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
- ↑ "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa".
- ↑ Yang Q, Doublié S (2011). "Structural biology of poly(A) site definition". Wiley Interdiscip Rev RNA. 2 (5): 723–747. doi:10.1002/wrna.88. PMC 3153407. PMID 21823232.
External links
- Human CPSF1 genome location and CPSF1 gene details page in the UCSC Genome Browser.
Further reading
- Keller W, Bienroth S, Lang KM, Christofori G (1992). "Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA". EMBO J. 10 (13): 4241–9. PMC 453176. PMID 1756731.
- Thuresson AC, Aström J, Aström A, et al. (1994). "Multiple forms of poly(A) polymerases in human cells". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 979–83. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.
- Schul W, Groenhout B, Koberna K, et al. (1996). "The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA". EMBO J. 15 (11): 2883–92. PMC 450226. PMID 8654386.
- McCracken S, Fong N, Yankulov K, et al. (1997). "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription". Nature. 385 (6614): 357–61. doi:10.1038/385357a0. PMID 9002523.
- Dantonel JC, Murthy KG, Manley JL, Tora L (1997). "Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA". Nature. 389 (6649): 399–402. doi:10.1038/38763. PMID 9311784.
- Takagaki Y, Manley JL (2000). "Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
- de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
- Samiotaki M, Balatsos NA, Courtis N, Tsiapalis CM (2001). "Assignment of the 160-kDa subunit of cleavage and polyadenylation specificity factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping". Cytogenet. Cell Genet. 90 (3–4): 234–5. doi:10.1159/000056776. PMID 11124521.
- McCracken S, Lambermon M, Blencowe BJ (2002). "SRm160 Splicing Coactivator Promotes Transcript 3′-End Cleavage". Mol. Cell. Biol. 22 (1): 148–60. doi:10.1128/MCB.22.1.148-160.2002. PMC 134228. PMID 11739730.
- Maeda Y, Ito M, Harashima N, et al. (2002). "Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients". Int. J. Cancer. 99 (3): 409–17. doi:10.1002/ijc.10377. PMID 11992410.
- Holland L, Gauthier L, Bell-Rogers P, Yankulov K (2002). "Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme". Eur. J. Biochem. 269 (21): 5192–202. doi:10.1046/j.1432-1033.2002.03224.x. PMID 12392551.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
 | This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |