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| | '''U4/U6 small nuclear ribonucleoprotein Prp4''' is a [[protein]] that in humans is encoded by the ''PRPF4'' [[gene]].<ref name="pmid9257651">{{cite journal | vauthors = Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R | title = The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p | journal = RNA | volume = 3 | issue = 8 | pages = 926–41 |date=Sep 1997 | pmid = 9257651 | pmc = 1369537 | doi = }}</ref><ref name="pmid9404889">{{cite journal | vauthors = Horowitz DS, Kobayashi R, Krainer AR | title = A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs | journal = RNA | volume = 3 | issue = 12 | pages = 1374–87 |date=Dec 1997 | pmid = 9404889 | pmc = 1369579 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref> | ||
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| summary_text = The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = | | summary_text = The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Horowitz DS, Krainer AR |title=A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. |journal=Genes Dev. |volume=11 |issue= 1 |pages= 139–51 |year= 1997 |pmid= 9000057 |doi=10.1101/gad.11.1.139 }} | ||
*{{cite journal |vauthors=Wang A, Forman-Kay J, Luo Y, etal |title=Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. |journal=Hum. Mol. Genet. |volume=6 |issue= 12 |pages= 2117–26 |year= 1997 |pmid= 9328476 |doi=10.1093/hmg/6.12.2117 }} | |||
*{{cite journal | *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal | *{{cite journal | vauthors=Heng HH, Wang A, Hu J |title=Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33. |journal=Genomics |volume=48 |issue= 2 |pages= 273–5 |year= 1998 |pmid= 9521884 |doi= 10.1006/geno.1997.5181 }} | ||
*{{cite journal |vauthors=Kojima T, Zama T, Wada K, etal |title=Cloning of human PRP4 reveals interaction with Clk1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32247–56 |year= 2001 |pmid= 11418604 |doi= 10.1074/jbc.M103790200 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Gonzalez-Santos JM, Wang A, Jones J, etal |title=Central region of the human splicing factor Hprp3p interacts with Hprp4p. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23764–72 |year= 2002 |pmid= 11971898 |doi= 10.1074/jbc.M111461200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Reidt U, Wahl MC, Fasshauer D, etal |title=Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. |journal=J. Mol. Biol. |volume=331 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 12875835 |doi=10.1016/S0022-2836(03)00684-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ingelfinger D, Göthel SF, Marahiel MA, etal |title=Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. |journal=Nucleic Acids Res. |volume=31 |issue= 16 |pages= 4791–6 |year= 2004 |pmid= 12907720 |doi=10.1093/nar/gkg660 | pmc=169899 }} | ||
*{{cite journal | *{{cite journal | vauthors=Stanĕk D, Neugebauer KM |title=Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. |journal=J. Cell Biol. |volume=166 |issue= 7 |pages= 1015–25 |year= 2004 |pmid= 15452143 |doi= 10.1083/jcb.200405160 | pmc=2172029 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }} | ||
*{{cite journal | *{{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal | vauthors=Liu S, Rauhut R, Vornlocher HP, Lührmann R |title=The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. |journal=RNA |volume=12 |issue= 7 |pages= 1418–30 |year= 2006 |pmid= 16723661 |doi= 10.1261/rna.55406 | pmc=1484429 }} | ||
*{{cite journal | *{{cite journal |vauthors=Huang B, Ahn YT, McPherson L, etal |title=Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081–7 |year= 2007 |pmid= 17513757 |doi= 10.4049/jimmunol.178.11.7081| pmc=2674583 }} | ||
*{{cite journal | | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{Post transcriptional modification}} | |||
[[Category:Spliceosome]] | |||
{{gene-9-stub}} |
Revision as of 18:45, 7 September 2017
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Species | Human | Mouse | |||||
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U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene.[1][2][3]
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][3]
References
- ↑ Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R (Sep 1997). "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p". RNA. 3 (8): 926–41. PMC 1369537. PMID 9257651.
- ↑ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
- ↑ 3.0 3.1 "Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Horowitz DS, Krainer AR (1997). "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor". Genes Dev. 11 (1): 139–51. doi:10.1101/gad.11.1.139. PMID 9000057.
- Wang A, Forman-Kay J, Luo Y, et al. (1997). "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome". Hum. Mol. Genet. 6 (12): 2117–26. doi:10.1093/hmg/6.12.2117. PMID 9328476.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33". Genomics. 48 (2): 273–5. doi:10.1006/geno.1997.5181. PMID 9521884.
- Kojima T, Zama T, Wada K, et al. (2001). "Cloning of human PRP4 reveals interaction with Clk1". J. Biol. Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
- Gonzalez-Santos JM, Wang A, Jones J, et al. (2002). "Central region of the human splicing factor Hprp3p interacts with Hprp4p". J. Biol. Chem. 277 (26): 23764–72. doi:10.1074/jbc.M111461200. PMID 11971898.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. PMID 12875835.
- Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
- Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP". RNA. 12 (7): 1418–30. doi:10.1261/rna.55406. PMC 1484429. PMID 16723661.
- Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
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