Autoimmune hepatitis risk factors: Difference between revisions
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{{CMG}}; {{AE}}:{{MKK}} | {{CMG}}; {{AE}}:{{MKK}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of Autoimmune hepatitis include female gender, Genetic predisposition associated with | Common risk factors in the development of [[Autoimmune hepatitis]] include [[female]] gender, [[Genetic predisposition]] associated with [[HLA]]DR3 and [[HLA]]DR4, and History of other [[Autoimmune hepatitis|autoimmune]] hepatitis eg [[thyroiditis]], [[type 1 diabetes]], [[ulcerative colitis]], [[celiac disease]], and [[rheumatoid arthritis]]. | ||
==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
Common risk factors in the development of Autoimmune hepatitis include: | Common risk factors in the development of [[Autoimmune hepatitis]] include: | ||
*Females: | *[[Females]]: | ||
**Autoimmune hepatitis is more common in young females | **Autoimmune hepatitis is more common in young females | ||
*Genetic predisposition:<ref name="pmid15288484">{{cite journal |vauthors=Donaldson PT |title=Genetics of autoimmune and viral liver diseases; understanding the issues |journal=J. Hepatol. |volume=41 |issue=2 |pages=327–32 |year=2004 |pmid=15288484 |doi=10.1016/j.jhep.2004.06.001 |url=}}</ref> | *[[Genetic predisposition]]:<ref name="pmid15288484">{{cite journal |vauthors=Donaldson PT |title=Genetics of autoimmune and viral liver diseases; understanding the issues |journal=J. Hepatol. |volume=41 |issue=2 |pages=327–32 |year=2004 |pmid=15288484 |doi=10.1016/j.jhep.2004.06.001 |url=}}</ref> | ||
**Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4 | **Autoimmune hepatitis type 1 has the association with [[HLA]]-DR3 and HLA-DR4 | ||
**Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles | **Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles | ||
*History of another autoimmune disease: | *History of another autoimmune disease: | ||
**Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis | **Autoimmune diseases, including [[thyroiditis]], [[type 1 diabetes]], [[ulcerative colitis]], [[celiac disease]], and [[rheumatoid arthritis]] | ||
===Less Common Risk Factors=== | ===Less Common Risk Factors=== | ||
Less common risk factors in the development of Autoimmune hepatitis include: | Less common risk factors in the development of Autoimmune hepatitis include: | ||
*A history of viral infections:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | *A history of [[viral infections]]:<ref name="pmid14871651">{{cite journal |vauthors=Vento S, Cainelli F |title=Is there a role for viruses in triggering autoimmune hepatitis? |journal=Autoimmun Rev |volume=3 |issue=1 |pages=61–9 |year=2004 |pmid=14871651 |doi=10.1016/S1568-9972(03)00053-3 |url=}}</ref><ref name="pmid7499793">{{cite journal |vauthors=Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH |title=Autoimmune hepatitis following hepatitis A virus infection |journal=J. Hepatol. |volume=23 |issue=2 |pages=204–8 |year=1995 |pmid=7499793 |doi= |url=}}</ref> | ||
**Autoimmune hepatitis is common who are infected with the measles, herpes simplex or Epstein-Barr virus and hepatitis A, B or C infection in the past. | **Autoimmune hepatitis is common who are infected with the [[measles]], [[herpes simplex]] or [[Epstein Barr virus|epstein-Barr virus]] and [[hepatitis A]], B or C infection in the past. | ||
*History of drug intake: | *History of drug intake: | ||
**[[Minocycline]], [[Nitrofurantoin]], [[Hydralazine]], [[Methyldopa]] [[Statins]], [[Fenofibrate]], [[Interferon]], [[Infliximab]], [[Etanercept]] increases the risk of autoimmune hepatitis | **[[Minocycline]], [[Nitrofurantoin]], [[Hydralazine]], [[Methyldopa]] [[Statins]], [[Fenofibrate]], [[Interferon]], [[Infliximab]], [[Etanercept]] increases the risk of autoimmune hepatitis | ||
Revision as of 00:25, 28 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Common risk factors in the development of Autoimmune hepatitis include female gender, Genetic predisposition associated with HLADR3 and HLADR4, and History of other autoimmune hepatitis eg thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis.
Risk Factors
Common Risk Factors
Common risk factors in the development of Autoimmune hepatitis include:
- Females:
- Autoimmune hepatitis is more common in young females
- Genetic predisposition:[1]
- Autoimmune hepatitis type 1 has the association with HLA-DR3 and HLA-DR4
- Type 2 AIH has an association with the HLA-DQB1 and HLA-DRB1 alleles
- History of another autoimmune disease:
- Autoimmune diseases, including thyroiditis, type 1 diabetes, ulcerative colitis, celiac disease, and rheumatoid arthritis
Less Common Risk Factors
Less common risk factors in the development of Autoimmune hepatitis include:
- A history of viral infections:[2][3]
- Autoimmune hepatitis is common who are infected with the measles, herpes simplex or epstein-Barr virus and hepatitis A, B or C infection in the past.
- History of drug intake:
- Minocycline, Nitrofurantoin, Hydralazine, Methyldopa Statins, Fenofibrate, Interferon, Infliximab, Etanercept increases the risk of autoimmune hepatitis
References
- ↑ Donaldson PT (2004). "Genetics of autoimmune and viral liver diseases; understanding the issues". J. Hepatol. 41 (2): 327–32. doi:10.1016/j.jhep.2004.06.001. PMID 15288484.
- ↑ Vento S, Cainelli F (2004). "Is there a role for viruses in triggering autoimmune hepatitis?". Autoimmun Rev. 3 (1): 61–9. doi:10.1016/S1568-9972(03)00053-3. PMID 14871651.
- ↑ Huppertz HI, Treichel U, Gassel AM, Jeschke R, Meyer zum Büschenfelde KH (1995). "Autoimmune hepatitis following hepatitis A virus infection". J. Hepatol. 23 (2): 204–8. PMID 7499793.