Autoimmune hepatitis natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 5: | Line 5: | ||
==Natural History== | ==Natural History== | ||
*The symptoms of Autoimmune hepatitis usually | *The symptoms of Autoimmune hepatitis usually has a bimodal age distribution, with a first peak of incidence at age 10-20 years and a second at age 45-70 years in the second decade of life, and start with asymptomatic to .<ref name="pmid28272079">{{cite journal |vauthors=Sonthalia N, Rathi PM, Jain SS, Surude RG, Mohite AR, Pawar SV, Contractor Q |title=Natural History and Treatment Outcomes of Severe Autoimmune Hepatitis |journal=J. Clin. Gastroenterol. |volume=51 |issue=6 |pages=548–556 |year=2017 |pmid=28272079 |doi=10.1097/MCG.0000000000000805 |url=}}</ref> | ||
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | *If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | ||
===Complications=== | ===Complications=== | ||
Common complications of Autoimmune hepatitis include:<ref name="pmid23634279">{{cite journal |vauthors=Trivedi PJ, Hirschfield GM |title=Treatment of autoimmune liver disease: current and future therapeutic options |journal=Ther Adv Chronic Dis |volume=4 |issue=3 |pages=119–41 |year=2013 |pmid=23634279 |pmc=3629750 |doi=10.1177/2040622313478646 |url=}}</ref><ref name="pmid21757447">{{cite journal |vauthors=Gleeson D, Heneghan MA |title=British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis |journal=Gut |volume=60 |issue=12 |pages=1611–29 |year=2011 |pmid=21757447 |doi=10.1136/gut.2010.235259 |url=}}</ref> | Common complications of [[Autoimmune hepatitis]] include:<ref name="pmid23634279">{{cite journal |vauthors=Trivedi PJ, Hirschfield GM |title=Treatment of autoimmune liver disease: current and future therapeutic options |journal=Ther Adv Chronic Dis |volume=4 |issue=3 |pages=119–41 |year=2013 |pmid=23634279 |pmc=3629750 |doi=10.1177/2040622313478646 |url=}}</ref><ref name="pmid21757447">{{cite journal |vauthors=Gleeson D, Heneghan MA |title=British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis |journal=Gut |volume=60 |issue=12 |pages=1611–29 |year=2011 |pmid=21757447 |doi=10.1136/gut.2010.235259 |url=}}</ref> | ||
*Cirrhosis and complications of cirrhosis | *[[Cirrhosis]] and complications of [[cirrhosis]]: | ||
**Ascites | **[[Ascites]] | ||
**Coagulopathy | **[[Coagulopathy]] | ||
**Liver failure | **[[Liver failure]] | ||
**Hepatocellular carcinoma | **[[Hepatocellular carcinoma]] | ||
**Hepatic encephalopathy | **[[Hepatic encephalopathy]] | ||
*Portal hypertension | *[[Portal hypertension]] | ||
*Esophageal varices | *[[Esophageal varices]] | ||
*Metabolic bone disease | *Metabolic bone disease | ||
*Hyperlipidaemia | *Hyperlipidaemia | ||
Revision as of 01:55, 28 December 2017
|
Autoimmune hepatitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Autoimmune hepatitis natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Autoimmune hepatitis natural history, complications and prognosis |
|
FDA on Autoimmune hepatitis natural history, complications and prognosis |
|
CDC on Autoimmune hepatitis natural history, complications and prognosis |
|
Autoimmune hepatitis natural history, complications and prognosis in the news |
|
Blogs on Autoimmune hepatitis natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Natural History
- The symptoms of Autoimmune hepatitis usually has a bimodal age distribution, with a first peak of incidence at age 10-20 years and a second at age 45-70 years in the second decade of life, and start with asymptomatic to .[1]
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
Common complications of Autoimmune hepatitis include:[2][3]
- Cirrhosis and complications of cirrhosis:
- Portal hypertension
- Esophageal varices
- Metabolic bone disease
- Hyperlipidaemia
- Hypovitaminosis of cholestasis
- Pruritis of cholestasis
Prognosis
- Prognosis is generally excellent, and the 10-year survival rate of patients with Autoimmune hepatitis treated with immunosuppressive therapy is approximately 80%.[4][5]
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis
References
- ↑ Sonthalia N, Rathi PM, Jain SS, Surude RG, Mohite AR, Pawar SV, Contractor Q (2017). "Natural History and Treatment Outcomes of Severe Autoimmune Hepatitis". J. Clin. Gastroenterol. 51 (6): 548–556. doi:10.1097/MCG.0000000000000805. PMID 28272079.
- ↑ Trivedi PJ, Hirschfield GM (2013). "Treatment of autoimmune liver disease: current and future therapeutic options". Ther Adv Chronic Dis. 4 (3): 119–41. doi:10.1177/2040622313478646. PMC 3629750. PMID 23634279.
- ↑ Gleeson D, Heneghan MA (2011). "British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis". Gut. 60 (12): 1611–29. doi:10.1136/gut.2010.235259. PMID 21757447.
- ↑ Hoeroldt B, McFarlane E, Dube A, Basumani P, Karajeh M, Campbell MJ, Gleeson D (2011). "Long-term outcomes of patients with autoimmune hepatitis managed at a nontransplant center". Gastroenterology. 140 (7): 1980–9. doi:10.1053/j.gastro.2011.02.065. PMID 21396370.
- ↑ D'Amico G, Garcia-Tsao G, Pagliaro L (2006). "Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies". J. Hepatol. 44 (1): 217–31. doi:10.1016/j.jhep.2005.10.013. PMID 16298014.