Colon polyps pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
*There are four different types of polyps including [[Inflammation|inflammatory]], [[Hamartoma|hamartomatous]], serrated, and adenomatous polyps, which have different [[pathogenesis]]. | *There are four different types of polyps including [[Inflammation|inflammatory]], [[Hamartoma|hamartomatous]], serrated, and adenomatous polyps, which have different [[pathogenesis]]. | ||
*The [[pathophysiology]] of colon polyps depends on the [[Histology|histological]] | *The [[pathophysiology]] of colon polyps depends on the [[Histology|histological]] type. | ||
*It is thought that colon polyps is mediated by either [hypothesis 2], or [hypothesis 3]. | *It is thought that colon polyps is mediated by either [hypothesis 2], or [hypothesis 3]. | ||
==== [[Inflammation|Inflammatory]] polyps ==== | ==== [[Inflammation|Inflammatory]] polyps ==== | ||
* [[Inflammation|Inflammatory]] polyps are non-neoplastic polyps that occur following [[Intestine|intestinal]] [[inflammation]], [[Infection|infections]], or [[ischemia]].<ref name="ShussmanWexner2014">{{cite journal|last1=Shussman|first1=N.|last2=Wexner|first2=S. D.|title=Colorectal polyps and polyposis syndromes|journal=Gastroenterology Report|volume=2|issue=1|year=2014|pages=1–15|issn=2052-0034|doi=10.1093/gastro/got041}}</ref><ref name="pmid17516746">{{cite journal |vauthors=Li SC, Burgart L |title=Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=3 |pages=440–5 |year=2007 |pmid=17516746 |doi=10.1043/1543-2165(2007)131[440:HOSAIV]2.0.CO;2 |url=}}</ref> | *[[Inflammation|Inflammatory]] polyps are non-neoplastic polyps that occur following [[Intestine|intestinal]] [[inflammation]], [[Infection|infections]], or [[ischemia]].<ref name="ShussmanWexner2014">{{cite journal|last1=Shussman|first1=N.|last2=Wexner|first2=S. D.|title=Colorectal polyps and polyposis syndromes|journal=Gastroenterology Report|volume=2|issue=1|year=2014|pages=1–15|issn=2052-0034|doi=10.1093/gastro/got041}}</ref><ref name="pmid17516746">{{cite journal |vauthors=Li SC, Burgart L |title=Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=3 |pages=440–5 |year=2007 |pmid=17516746 |doi=10.1043/1543-2165(2007)131[440:HOSAIV]2.0.CO;2 |url=}}</ref> | ||
* They mostly occur in patients with [[inflammatory bowel disease]], mainly [[ulcerative colitis]]. | *They mostly occur in patients with [[inflammatory bowel disease]], mainly [[ulcerative colitis]]. | ||
* | *They are considered as pseudopolyps which contain inflammatory infiltrations with distorted mucosal anatomy. | ||
* | |||
==== [[Hamartoma|Hamartomatous]] polyps ==== | ==== [[Hamartoma|Hamartomatous]] polyps ==== | ||
Revision as of 15:06, 19 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- There are four different types of polyps including inflammatory, hamartomatous, serrated, and adenomatous polyps, which have different pathogenesis.
- The pathophysiology of colon polyps depends on the histological type.
- It is thought that colon polyps is mediated by either [hypothesis 2], or [hypothesis 3].
Inflammatory polyps
- Inflammatory polyps are non-neoplastic polyps that occur following intestinal inflammation, infections, or ischemia.[1][2]
- They mostly occur in patients with inflammatory bowel disease, mainly ulcerative colitis.
- They are considered as pseudopolyps which contain inflammatory infiltrations with distorted mucosal anatomy.
Hamartomatous polyps
Serrated polyps
Adenomatous polyps
Genetics
- The development of colon polyps is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
 |
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Shussman, N.; Wexner, S. D. (2014). "Colorectal polyps and polyposis syndromes". Gastroenterology Report. 2 (1): 1–15. doi:10.1093/gastro/got041. ISSN 2052-0034.
- ↑ Li SC, Burgart L (2007). "Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps". Arch. Pathol. Lab. Med. 131 (3): 440–5. doi:10.1043/1543-2165(2007)131[440:HOSAIV]2.0.CO;2. PMID 17516746.
- ↑ "File:Image of resected colon segment with cancer & 4 nearby polyps plus schematic of field defects with sub-clones.jpg - Wikimedia Commons".