Colon polyps natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Colon polyps are very common in general population. They are usually found during screening [[colonoscopy]]. Polyps might grow gradually and cause symptoms including [[obstruction]], [[bleeding]], and changes in [[Defecation|bowel habits]]. Some of them might progress to [[colorectal cancer]]. Therefore, it is advisable to resect all polyps that are found during [[colonoscopy]] and send the tissue [[biopsy]] for [[pathology]]. Prognosis of colon polyps is generally excellent. The presence of multiple polyps is associated with [[Genetics|genetic]] disorders with a particularly poor prognosis. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
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*Colon polyps are very common in general population.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | *Colon polyps are very common in general population.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | ||
*They are usually found during screening [[colonoscopy]].<ref name="Bonnington2016">{{cite journal|last1=Bonnington|first1=Stewart N|title=Surveillance of colonic polyps: Are we getting it right?|journal=World Journal of Gastroenterology|volume=22|issue=6|year=2016|pages=1925|issn=1007-9327|doi=10.3748/wjg.v22.i6.1925}}</ref> | *They are usually found during screening [[colonoscopy]].<ref name="Bonnington2016">{{cite journal|last1=Bonnington|first1=Stewart N|title=Surveillance of colonic polyps: Are we getting it right?|journal=World Journal of Gastroenterology|volume=22|issue=6|year=2016|pages=1925|issn=1007-9327|doi=10.3748/wjg.v22.i6.1925}}</ref> | ||
*Polyps might grow and cause symptoms including [[obstruction]], [[bleeding]], and changes in bowel habits. | *Polyps might grow gradually and cause symptoms including [[obstruction]], [[bleeding]], and changes in [[Defecation|bowel habits]]. | ||
*Some of them might have [[malignant]] potential. | *Some of them might have [[malignant]] potential. | ||
*If left untreated, it may progress to develop [[colorectal cancer]]. | *If left untreated, it may progress to develop [[colorectal cancer]]. The progression from an [[adenomatous polyp]] to colorectal cancer may take 10-15 years. | ||
*All polyps are recommended to be resected. | *All polyps are recommended to be resected. | ||
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===Prognosis=== | ===Prognosis=== | ||
*Prognosis of colon polyps is generally excellent.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | *Prognosis of colon polyps is generally excellent.<ref name="HuangFarraye2010">{{cite journal|last1=Huang|first1=Christopher S|last2=Farraye|first2=Francis A|last3=Yang|first3=Shi|last4=O'Brien|first4=Michael J|title=The Clinical Significance of Serrated Polyps|journal=The American Journal of Gastroenterology|volume=106|issue=2|year=2010|pages=229–240|issn=0002-9270|doi=10.1038/ajg.2010.429}}</ref> | ||
*The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis. | *The presence of multiple [[Polyp|polyps]] is associated with [[Genetics|genetic]] disorders with a particularly poor prognosis. | ||
*Colon polyps that are associated with BRAF and KRAS mutations have a poor prognosis.<ref name="BettingtonWalker2013">{{cite journal|last1=Bettington|first1=Mark|last2=Walker|first2=Neal|last3=Clouston|first3=Andrew|last4=Brown|first4=Ian|last5=Leggett|first5=Barbara|last6=Whitehall|first6=Vicki|title=The serrated pathway to colorectal carcinoma: current concepts and challenges|journal=Histopathology|volume=62|issue=3|year=2013|pages=367–386|issn=03090167|doi=10.1111/his.12055}}</ref> | *Colon polyps that are associated with [[BRAF]] and [[KRAS]] mutations have a poor prognosis.<ref name="BettingtonWalker2013">{{cite journal|last1=Bettington|first1=Mark|last2=Walker|first2=Neal|last3=Clouston|first3=Andrew|last4=Brown|first4=Ian|last5=Leggett|first5=Barbara|last6=Whitehall|first6=Vicki|title=The serrated pathway to colorectal carcinoma: current concepts and challenges|journal=Histopathology|volume=62|issue=3|year=2013|pages=367–386|issn=03090167|doi=10.1111/his.12055}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Revision as of 17:11, 22 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Colon polyps are very common in general population. They are usually found during screening colonoscopy. Polyps might grow gradually and cause symptoms including obstruction, bleeding, and changes in bowel habits. Some of them might progress to colorectal cancer. Therefore, it is advisable to resect all polyps that are found during colonoscopy and send the tissue biopsy for pathology. Prognosis of colon polyps is generally excellent. The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis.
Natural History, Complications, and Prognosis
Natural History
- Colon polyps are very common in general population.[1]
- They are usually found during screening colonoscopy.[2]
- Polyps might grow gradually and cause symptoms including obstruction, bleeding, and changes in bowel habits.
- Some of them might have malignant potential.
- If left untreated, it may progress to develop colorectal cancer. The progression from an adenomatous polyp to colorectal cancer may take 10-15 years.
- All polyps are recommended to be resected.
Complications
Prognosis
- Prognosis of colon polyps is generally excellent.[1]
- The presence of multiple polyps is associated with genetic disorders with a particularly poor prognosis.
- Colon polyps that are associated with BRAF and KRAS mutations have a poor prognosis.[4]
References
- ↑ 1.0 1.1 Huang, Christopher S; Farraye, Francis A; Yang, Shi; O'Brien, Michael J (2010). "The Clinical Significance of Serrated Polyps". The American Journal of Gastroenterology. 106 (2): 229–240. doi:10.1038/ajg.2010.429. ISSN 0002-9270.
- ↑ 2.0 2.1 Bonnington, Stewart N (2016). "Surveillance of colonic polyps: Are we getting it right?". World Journal of Gastroenterology. 22 (6): 1925. doi:10.3748/wjg.v22.i6.1925. ISSN 1007-9327.
- ↑ Shussman, N.; Wexner, S. D. (2014). "Colorectal polyps and polyposis syndromes". Gastroenterology Report. 2 (1): 1–15. doi:10.1093/gastro/got041. ISSN 2052-0034.
- ↑ Bettington, Mark; Walker, Neal; Clouston, Andrew; Brown, Ian; Leggett, Barbara; Whitehall, Vicki (2013). "The serrated pathway to colorectal carcinoma: current concepts and challenges". Histopathology. 62 (3): 367–386. doi:10.1111/his.12055. ISSN 0309-0167.