Sinusoidal obstruction syndrome risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
Common risk factors for sinusoidal obstruction syndrome are:<ref name="pmid12744547">{{cite journal| author=Kumar S, DeLeve LD, Kamath PS, Tefferi A| title=Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. | journal=Mayo Clin Proc | year= 2003 | volume= 78 | issue= 5 | pages= 589-98 | pmid=12744547 | doi=10.4065/78.5.589 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12744547 }} </ref> | |||
*Stem cell transplantation | *Stem cell transplantation | ||
*Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | *Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Risk Factors
Common risk factors for sinusoidal obstruction syndrome are:[1]
- Stem cell transplantation
- Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation)
- Presence of hepatic metastases
- Advanced age
- Prior radiation treatment of the liver
- High-dose conditioning regimens
- Allogeneic transplantation (compared with autologous transplantation)
References
- ↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). "Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation". Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.