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Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens. | Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens. | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors for sinusoidal obstruction syndrome are:<ref name="pmid12744547">{{cite journal| author=Kumar S, DeLeve LD, Kamath PS, Tefferi A| title=Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. | journal=Mayo Clin Proc | year= 2003 | volume= 78 | issue= 5 | pages= 589-98 | pmid=12744547 | doi=10.4065/78.5.589 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12744547 }} </ref> | Common risk factors for sinusoidal obstruction syndrome are:<ref name="pmid12744547">{{cite journal| author=Kumar S, DeLeve LD, Kamath PS, Tefferi A| title=Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. | journal=Mayo Clin Proc | year= 2003 | volume= 78 | issue= 5 | pages= 589-98 | pmid=12744547 | doi=10.4065/78.5.589 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12744547 }} </ref><ref name="pmid8420443">{{cite journal |vauthors=McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA |title=Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients |journal=Ann. Intern. Med. |volume=118 |issue=4 |pages=255–67 |year=1993 |pmid=8420443 |doi= |url=}}</ref> | ||
*Stem cell transplantation | *Stem cell transplantation | ||
*Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | *Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation) | ||
| Line 13: | Line 13: | ||
*High-dose conditioning regimens | *High-dose conditioning regimens | ||
*Allogeneic transplantation (compared with autologous transplantation) | *Allogeneic transplantation (compared with autologous transplantation) | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens.
Risk Factors
Common risk factors for sinusoidal obstruction syndrome are:[1][2]
- Stem cell transplantation
- Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low pseudocholinesterase level or low albumin level pretransplantation)
- Presence of hepatic metastases
- Advanced age
- Prior radiation treatment of the liver
- High-dose conditioning regimens
- Allogeneic transplantation (compared with autologous transplantation)
References
- ↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). "Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation". Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.
- ↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.