Sinusoidal obstruction syndrome diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Diagnostic Criteria

The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction.

• The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:

Baltimore Criteria	Seattle criteria
Within 30 days of transplantation, bilirubinemia > 34.2 mol/L (2 mg/dL), plus 2 other findings among the following: Hepatomegaly, usually painful  > 5% weight gain Ascites	Within 20 days of transplantation, two of three findings among the following: Bilirubin > 34.2 mol/L (2 mg/dL) Hepatomegaly or RUQ pain of liver origin > 2% weight gain due to fluid accumulation