Sinusoidal obstruction syndrome diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are Baltimore criteria and modified Seattle criteria.

Diagnostic Criteria

The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction.

• The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:

Baltimore Criteria	Seattle criteria
Within 30 days of transplantation, bilirubinemia > 34.2 mol/L (2 mg/dL), plus 2 other findings among the following: Hepatomegaly, usually painful  > 5% weight gain Ascites	Within 20 days of transplantation, two of three findings among the following: Bilirubin > 34.2 mol/L (2 mg/dL) Hepatomegaly or RUQ pain of liver origin > 2% weight gain due to fluid accumulation