Oral cancer differential diagnosis: Difference between revisions

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==Overview==
==Overview==
There are different types of cancers of the oral cavity and oropharynx. It is important that they are differentiated from one another. 
Oral cancer must be differentiated from [[actinic keratosis]], dermatologic manifestations of oral [[leukoplakia]], erythroplasia, [[lichen planus]] and mucosal candidiasis.  
Oral cancer must be differentiated from [[actinic keratosis]], dermatologic manifestations of oral [[leukoplakia]], erythroplasia, [[lichen planus]] and mucosal candidiasis.  
==Oral cancer differential diagnosis==
==Oral cancer differential diagnosis==
*[[Actinic keratosis]]
{| class="wikitable"
*Dermatologic manifestations of oral leukoplakia
!Type of cancer
*Erythroplasia
!Subtype
*[[Lichen planus]]
!ICD-O Code
*[[candidiasis|Mucosal candidiasis]]
!Epidemiology
!Etiology
!Second primary tumors
!Localization
!Clinical features
!Diagnostic procedures
|-
| rowspan="7" |Squamous cell carcinoma
|Verrucous carcinoma
|8051/3
|Older males
|
* Chronic smokeless tobacco
* HPV 16 and 18
|
|
|
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|-
|Basaloid squamous cell carcinoma
|8083/3
|
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|
|
|
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|-
|Papillary squamous cell carcinoma
|8052/3
|
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|
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|-
|Spindle cell carcinoma
|8074/3
|
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|
|
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|-
|Acantholytic squamous cell carcinoma
|8075/3
|
|
|
|
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|-
|Adenosquamous carcinoma
|8560/3
|
|
|
|
|
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|-
|Carcinoma cuniculatum
 
(epithelioma cuniculatum)
|8051/3
|
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|-
|Lymphoepithelial carcinoma
|
|
|
|
|
|
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|-
|Epithelial precursor lesions
|
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|
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|-
|Proliferative verrucous leukoplakia and precancerous conditions
|
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|-
| rowspan="4" |Papillomas
|Squamous cell papilloma and
verruca vulgaris
|
|
|
|
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|-
|Condyloma acuminatum
|
|
|
|
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|-
|Papillomas and papillomatosis
in immunodeficiency
|
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|-
|Focal epithelial hyperplasia
|
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|-
|Granular cell tumour
|
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|-
|Keratoacanthoma
|
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|-
|Papillary hyperplasia
|
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|-
|Median rhomboid glossitis
|
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|-
|Median rhomboid glossitis
|
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|-
| rowspan="13" |Salivary gland tumours
|Acinic cell carcinoma
|8550/3
|
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|-
|Mucoepidermoid carcinoma
|8430/3
|
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|-
|Adenoid cystic carcinoma
|8200/3
|
|
|
|
|
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|-
|Polymorphous low-grade
adenocarcinoma               
|8525/3
|
|
|
|
|
|
|-
|Epithelial-myoepithelial
carcinoma                         
|8562/3
|
|
|
|
|
|
|-
|Clear cell carcinoma,
NOS
|8310/3
|
|
|
|
|
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|-
|Basal cell
adenocarcinoma
|8147/3
|
|
|
|
|
|
|-
|Cystadenocarcinoma       
|8450/3
|
|
|
|
|
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|-
|Mucinous adenocarcinoma
|8480/3
|
|
|
|
|
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|-
|Oncocytic carcinoma
|8290/3
|
|
|
|
|
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|-
|Salivary duct carcinoma
|8500/3
|
|
|
|
|
|
|-
|Myoepithelial carcinoma
|8982/3
|
|
|
|
|
|
|-
|Carcinoma ex pleomorphic
adenoma                           
|8941/3
|
|
|
|
|
|
|-
| rowspan="6" |Salivary gland adenomas
|Pleomorphic adenoma
|8940/0
|
|
|
|
|
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|-
|Myoepithelioma
|8982/0
|
|
|
|
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|-
|Basal cell adenoma
|8147/0
|
|
|
|
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|-
|Canalicular adenoma
|8149/0
|
|
|
|
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|-
|Duct papilloma
|8503/0
|
|
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|
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|-
|Cystadenoma
|8440/0
|
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|-
|Kaposi sarcoma
|
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|-
|Lymphangioma
|
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|-
|Ectomesenchymal chondromyxoid
tumour of the anterior tongue
|
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|-
|Focal oral mucinosis
|
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|-
|Congenital granular cell epulis
|
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|-
| rowspan="6" |Haematolymphoid tumours
|Non-Hodgkin lymphoma
|
|
|
|
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|-
|Extramedullary plasmacytoma
|
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|-
|Langerhans cell histiocytosis
|
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|-
|Hodgkin lymphoma
|
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|-
|Extramedullary myeloid
sarcoma
|
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|-
|Follicular dendritic cell
sarcoma / tumour
|
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|-
|Mucosal malignant melanoma
|
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|-
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|-
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|}


==References==
==References==

Revision as of 17:02, 5 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

There are different types of cancers of the oral cavity and oropharynx. It is important that they are differentiated from one another.

Oral cancer must be differentiated from actinic keratosis, dermatologic manifestations of oral leukoplakia, erythroplasia, lichen planus and mucosal candidiasis.

Oral cancer differential diagnosis

Type of cancer Subtype ICD-O Code Epidemiology Etiology Second primary tumors Localization Clinical features Diagnostic procedures
Squamous cell carcinoma Verrucous carcinoma 8051/3 Older males
  • Chronic smokeless tobacco
  • HPV 16 and 18
Basaloid squamous cell carcinoma 8083/3
Papillary squamous cell carcinoma 8052/3
Spindle cell carcinoma 8074/3
Acantholytic squamous cell carcinoma 8075/3
Adenosquamous carcinoma 8560/3
Carcinoma cuniculatum

(epithelioma cuniculatum)

8051/3
Lymphoepithelial carcinoma
Epithelial precursor lesions
Proliferative verrucous leukoplakia and precancerous conditions
Papillomas Squamous cell papilloma and

verruca vulgaris

Condyloma acuminatum
Papillomas and papillomatosis

in immunodeficiency

Focal epithelial hyperplasia
Granular cell tumour
Keratoacanthoma
Papillary hyperplasia
Median rhomboid glossitis
Median rhomboid glossitis
Salivary gland tumours Acinic cell carcinoma 8550/3
Mucoepidermoid carcinoma 8430/3
Adenoid cystic carcinoma 8200/3
Polymorphous low-grade

adenocarcinoma

8525/3
Epithelial-myoepithelial

carcinoma

8562/3
Clear cell carcinoma,

NOS

8310/3
Basal cell

adenocarcinoma

8147/3
Cystadenocarcinoma 8450/3
Mucinous adenocarcinoma 8480/3
Oncocytic carcinoma 8290/3
Salivary duct carcinoma 8500/3
Myoepithelial carcinoma 8982/3
Carcinoma ex pleomorphic

adenoma

8941/3
Salivary gland adenomas Pleomorphic adenoma 8940/0
Myoepithelioma 8982/0
Basal cell adenoma 8147/0
Canalicular adenoma 8149/0
Duct papilloma 8503/0
Cystadenoma 8440/0
Kaposi sarcoma
Lymphangioma
Ectomesenchymal chondromyxoid

tumour of the anterior tongue

Focal oral mucinosis
Congenital granular cell epulis
Haematolymphoid tumours Non-Hodgkin lymphoma
Extramedullary plasmacytoma
Langerhans cell histiocytosis
Hodgkin lymphoma
Extramedullary myeloid

sarcoma

Follicular dendritic cell

sarcoma / tumour

Mucosal malignant melanoma

References


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