Primary biliary cirrhosis medical therapy: Difference between revisions
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*'''4''' '''Peroxisome proliferator-activated receptor agonist ''' | *'''4''' '''Peroxisome proliferator-activated receptor agonist ''' | ||
** [[Fibrates]] | ** [[Fibrates]] | ||
===Symptomatic Therapy=== | |||
'''1'''.'''Pruritus''' | |||
*1st line | |||
**Cholestyramine 4 g/d (before + after breakfast) | |||
*2nd line | |||
**Rifampin 150 mg bid | |||
*3rd line | |||
**Sertraline (anti-depressant) | |||
*4th line | |||
**Naloxone, by an experienced physician | |||
*5th line | |||
**Liver transplantation | |||
'''2.''''''Supportive ''' | |||
*UV light,Sunlight | |||
'''3.''''''Emergency''' | |||
*Plasmapheresis | |||
'''4.''''''Raynauds''' | |||
*1st line:Ca channel blockers | |||
*2nd line:Alternative: prostacyclin and its derivatives, endothelin receptor antagonists and phosphodiesterase inhibitors | |||
'''5.''''''Sicca syndrome''' | |||
*Dry eyes | |||
**Artificial tears | |||
*Dry mouth | |||
**Dental hygiene | |||
***Dental visit every 3–6 months | |||
*Dry vagina | |||
**Vaginal lubricants | |||
==References== | ==References== |
Revision as of 20:02, 5 February 2018
Primary Biliary Cirrhosis Microchapters |
Differentiating Primary Biliary Cirrhosis from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Primary biliary cirrhosis medical therapy On the Web |
American Roentgen Ray Society Images of Primary biliary cirrhosis medical therapy |
Risk calculators and risk factors for Primary biliary cirrhosis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]
Overview
Pharmacologic medical therapies for Primary biliary cirrhosis include Immunomodulators,antifibrotics and anticholestatics. The anticholestatic Ursodeoxycholic acid (UDCA) is recommended as the first line medical therapy for PBC.
Medical Therapy
- Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].
- Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
- Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].
- Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].
Primary biliary cirrhosis
- 1 Anticholestatics
- 1.1 Preferred regimen : Ursodeoxycholic acid (UDCA) 13-15 mg PO q12h for 10-21 days (Contraindications/specific instructions)
- 2 Immunomodulator
- 2.1 Glucocorticoid
- Preferred regimen :Budesonide 6 to 9 mg per day PO (contraindicated for patients who have hypersensitivity to budesonide)
- Alternative regimen:Cyclosporine: 5-10 mg PO q24h
- 2.1 Glucocorticoid
- 3 Farnesoid-X-receptor (FXR) agonist
- 3.1 Obetocholic acid
- 4 Peroxisome proliferator-activated receptor agonist
Symptomatic Therapy
1.Pruritus
- 1st line
- Cholestyramine 4 g/d (before + after breakfast)
- 2nd line
- Rifampin 150 mg bid
- 3rd line
- Sertraline (anti-depressant)
- 4th line
- Naloxone, by an experienced physician
- 5th line
- Liver transplantation
'2.'Supportive
- UV light,Sunlight
'3.'Emergency
- Plasmapheresis
'4.'Raynauds
- 1st line:Ca channel blockers
- 2nd line:Alternative: prostacyclin and its derivatives, endothelin receptor antagonists and phosphodiesterase inhibitors
'5.'Sicca syndrome
- Dry eyes
- Artificial tears
- Dry mouth
- Dental hygiene
- Dental visit every 3–6 months
- Dental hygiene
- Dry vagina
- Vaginal lubricants