Primary biliary cirrhosis classification: Difference between revisions
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* However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.<ref name="pmid19554543">{{cite journal| author=Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ et al.| title=Primary biliary cirrhosis. | journal=Hepatology | year= 2009 | volume= 50 | issue= 1 | pages= 291-308 | pmid=19554543 | doi=10.1002/hep.22906 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19554543 }} </ref><ref name="pmid150690">{{cite journal| author=Ludwig J, Dickson ER, McDonald GS| title=Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). | journal=Virchows Arch A Pathol Anat Histol | year= 1978 | volume= 379 | issue= 2 | pages= 103-12 | pmid=150690 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=150690 }} </ref> | * However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.<ref name="pmid19554543">{{cite journal| author=Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ et al.| title=Primary biliary cirrhosis. | journal=Hepatology | year= 2009 | volume= 50 | issue= 1 | pages= 291-308 | pmid=19554543 | doi=10.1002/hep.22906 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19554543 }} </ref><ref name="pmid150690">{{cite journal| author=Ludwig J, Dickson ER, McDonald GS| title=Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). | journal=Virchows Arch A Pathol Anat Histol | year= 1978 | volume= 379 | issue= 2 | pages= 103-12 | pmid=150690 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=150690 }} </ref> | ||
* It can also be classified into four stages according to the histological classification of P. Scheuer.<ref name="pmid6066569">{{cite journal| author=Scheuer P| title=Primary biliary cirrhosis. | journal=Proc R Soc Med | year= 1967 | volume= 60 | issue= 12 | pages= 1257-60 | pmid=6066569 | doi= | pmc=1901478 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6066569 }}</ref> | * It can also be classified into four stages according to the histological classification of P. Scheuer.<ref name="pmid6066569">{{cite journal| author=Scheuer P| title=Primary biliary cirrhosis. | journal=Proc R Soc Med | year= 1967 | volume= 60 | issue= 12 | pages= 1257-60 | pmid=6066569 | doi= | pmc=1901478 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6066569 }}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! Classification of Primary biliary cirrhosis on the basis of histology | ! colspan="3" | Classification of Primary biliary cirrhosis on the basis of histology | ||
|- | |- | ||
!Ludwig classification | | rowspan="2" |Stage | ||
! Ludwig classification | |||
! Scheuer's classification | |||
|- | |- | ||
| | | colspan="2" | Histologic appearance | ||
|Histologic | |||
|- | |- | ||
|Stage 0 | |Stage 0 | ||
|Normal liver | |Normal liver | ||
|florid duct lesion or chronic non-suppurative destructive cholangitis | |||
|- | |- | ||
|Stage 1 | |Stage 1 | ||
|Stage 1 is characterized by portal inflammation | |Stage 1 is characterized by portal inflammation | ||
|proliferation of the small bile ductules | |||
|- | |- | ||
|Stage 2 | |Stage 2 | ||
|Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss | |Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss | ||
|fibrosis or scarring | |||
|- | |- | ||
|Stage 3 | |Stage 3 | ||
|There is presence of fibrous septa linking adjacent portal tracts | |There is presence of fibrous septa linking adjacent portal tracts | ||
|cirrhosis | |||
|- | |- | ||
|Stage 4 | |Stage 4 | ||
|Stage 4 is characterized by cirrhosis | |Stage 4 is characterized by cirrhosis | ||
|} | |} | ||
==References== | ==References== | ||
Revision as of 20:28, 5 February 2018
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Primary Biliary Cirrhosis Microchapters |
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Differentiating Primary Biliary Cirrhosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Primary biliary cirrhosis classification On the Web |
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American Roentgen Ray Society Images of Primary biliary cirrhosis classification |
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Risk calculators and risk factors for Primary biliary cirrhosis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
There is no established system for the classification of Primary biliary cirrhosis. However, it can be classified into four stages depending on the histology of the disease.[1]
Classification
- There is no established system for the classification of primary biliary cirrhosis.
- However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.[1][2]
- It can also be classified into four stages according to the histological classification of P. Scheuer.[3]
| Classification of Primary biliary cirrhosis on the basis of histology | ||
|---|---|---|
| Stage | Ludwig classification | Scheuer's classification |
| Histologic appearance | ||
| Stage 0 | Normal liver | florid duct lesion or chronic non-suppurative destructive cholangitis |
| Stage 1 | Stage 1 is characterized by portal inflammation | proliferation of the small bile ductules |
| Stage 2 | Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss | fibrosis or scarring |
| Stage 3 | There is presence of fibrous septa linking adjacent portal tracts | cirrhosis |
| Stage 4 | Stage 4 is characterized by cirrhosis | |
References
- ↑ 1.0 1.1 Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ; et al. (2009). "Primary biliary cirrhosis". Hepatology. 50 (1): 291–308. doi:10.1002/hep.22906. PMID 19554543.
- ↑ Ludwig J, Dickson ER, McDonald GS (1978). "Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)". Virchows Arch A Pathol Anat Histol. 379 (2): 103–12. PMID 150690.
- ↑ Scheuer P (1967). "Primary biliary cirrhosis". Proc R Soc Med. 60 (12): 1257–60. PMC 1901478. PMID 6066569.