Sinusoidal obstruction syndrome primary prevention: Difference between revisions
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==Primary Prevention== | ==Primary Prevention== | ||
Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include:<ref name="pmid24102514">{{cite journal |vauthors=Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN |title=BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation |journal=Br. J. Haematol. |volume=163 |issue=4 |pages=444–57 |year=2013 |pmid=24102514 |doi=10.1111/bjh.12558 |url=}}</ref><ref name="pmid24102514">{{cite journal |vauthors=Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN |title=BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation |journal=Br. J. Haematol. |volume=163 |issue=4 |pages=444–57 |year=2013 |pmid=24102514 |doi=10.1111/bjh.12558 |url=}}</ref> | |||
* Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials. | |||
* The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects. | |||
* Treatment of preexisting liver disease. | |||
* The prophylaxis for graft vs host disease should be considered. | |||
==References== | ==References== | ||
Revision as of 21:23, 5 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Primary Prevention
Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include:[1][1]
- Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials.
- The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects.
- Treatment of preexisting liver disease.
- The prophylaxis for graft vs host disease should be considered.
References
- ↑ 1.0 1.1 Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN (2013). "BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation". Br. J. Haematol. 163 (4): 444–57. doi:10.1111/bjh.12558. PMID 24102514.