Primary biliary cirrhosis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:<ref name="pmid18215315">{{cite journal| author=Kumagi T, Heathcote EJ| title=Primary biliary cirrhosis. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 1 | pmid=18215315 | doi=10.1186/1750-1172-3-1 | pmc=2266722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18215315 }} </ref><ref name="pmid12853201">{{cite journal| author=Talwalkar JA, Lindor KD| title=Primary biliary cirrhosis. | journal=Lancet | year= 2003 | volume= 362 | issue= 9377 | pages= 53-61 | pmid=12853201 | doi=10.1016/S0140-6736(03)13808-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12853201 }} </ref><ref name="pmid3793004">{{cite journal| author=Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ et al.| title=Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis? | journal=Hepatology | year= 1986 | volume= 6 | issue= 6 | pages= 1279-84 | pmid=3793004 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3793004 }} </ref> | *Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:<ref name="pmid18215315">{{cite journal| author=Kumagi T, Heathcote EJ| title=Primary biliary cirrhosis. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 1 | pmid=18215315 | doi=10.1186/1750-1172-3-1 | pmc=2266722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18215315 }} </ref><ref name="pmid12853201">{{cite journal| author=Talwalkar JA, Lindor KD| title=Primary biliary cirrhosis. | journal=Lancet | year= 2003 | volume= 362 | issue= 9377 | pages= 53-61 | pmid=12853201 | doi=10.1016/S0140-6736(03)13808-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12853201 }} </ref><ref name="pmid3793004">{{cite journal| author=Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ et al.| title=Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis? | journal=Hepatology | year= 1986 | volume= 6 | issue= 6 | pages= 1279-84 | pmid=3793004 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3793004 }} </ref><ref name="pmid1568727">{{cite journal| author=Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA et al.| title=Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk? | journal=Hepatology | year= 1992 | volume= 15 | issue= 5 | pages= 858-62 | pmid=1568727 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1568727 }} </ref> | ||
**Hyperbilirubinemia | **Hyperbilirubinemia | ||
**Elevated alkaline phosphatase (2–10 times upper limit of normal) | **Elevated alkaline phosphatase (2–10 times upper limit of normal) | ||
**Elevated gamma-glutamyl transpeptidase (GGT) | **Elevated gamma-glutamyl transpeptidase (GGT) | ||
**Elevated serum anti-mitochondrial antibodies (AMA) in 90% more than 90% patients (titres of 1/40 or greater) | **Elevated serum anti-mitochondrial antibodies (AMA) in 90% more than 90% patients (titres of 1/40 or greater) | ||
**Hyperlipidemia | |||
**Elevated immunoglobulin M | **Elevated immunoglobulin M | ||
**Elevated liver aminotransferase | **Elevated liver aminotransferase | ||
Revision as of 17:04, 6 February 2018
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Primary Biliary Cirrhosis Microchapters |
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Differentiating Primary Biliary Cirrhosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Primary biliary cirrhosis laboratory findings On the Web |
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American Roentgen Ray Society Images of Primary biliary cirrhosis laboratory findings |
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Risk calculators and risk factors for Primary biliary cirrhosis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal among patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:[1][2][3][4]
- Hyperbilirubinemia
- Elevated alkaline phosphatase (2–10 times upper limit of normal)
- Elevated gamma-glutamyl transpeptidase (GGT)
- Elevated serum anti-mitochondrial antibodies (AMA) in 90% more than 90% patients (titres of 1/40 or greater)
- Hyperlipidemia
- Elevated immunoglobulin M
- Elevated liver aminotransferase
- Some patients with primary biliary cirrhosis may have "nuclear-rim" and "multiple nuclear-dot" patterns, which is highly specific for primary biliary cirrhosis, particularly in AMA-negative patients.
- Some patients with primary biliary cirrhosis may have elevated antinuclear antibody (35% patients) and smooth muscle (66% patients) antibody.
References
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.
- ↑ Talwalkar JA, Lindor KD (2003). "Primary biliary cirrhosis". Lancet. 362 (9377): 53–61. doi:10.1016/S0140-6736(03)13808-1. PMID 12853201.
- ↑ Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ; et al. (1986). "Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?". Hepatology. 6 (6): 1279–84. PMID 3793004.
- ↑ Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA; et al. (1992). "Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?". Hepatology. 15 (5): 858–62. PMID 1568727.