Multiple sclerosis differential diagnosis: Difference between revisions
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Multiple sclerosis must be differentiated from other diseases that can mimic this disease clinically or radiologically such as: | Multiple sclerosis must be differentiated from other diseases that can mimic this disease clinically or radiologically such as: | ||
==== Inflammatory conditions: ==== | ==== Inflammatory/autoimmune conditions: ==== | ||
* systemic lupus erythematosus | * '''systemic lupus erythematosus:''' Systemic lupus erythromatosus can cause neurological manifestations such as seizures, movement disorders, transverse myelitis, cranial and peripheral neuropathies and optic nerve involvement. In the brain MRI of SLE patients there are evidences of atrophy and subcortical white matter lesions. SLE is diagnosed based on systemic manifestations, present of oligoclonal bands and IgG in CSF and high titer of antinuclear antibodies. | ||
* Sjögren’s syndrome | * '''Sjögren’s syndrome:''' Sjogren disease can cause neurological manifestations including cerebral vasculitis, myopathy, transvers myelitis and acute optic neuropathy. There are evidence of oligoclonal band and increased IgG in CSF and white matter lesions in MRI. Sicca syndrome, rheumatic manifestation and high titers of ANA,SSRo and SS-La will confirm the diagnosis.. | ||
* Vasculitis | * '''Vasculitis:''' | ||
* Behçet’s disease | * '''Behçet’s disease:''' | ||
* sarcoidosis | * '''sarcoidosis:''' | ||
==== Infections: ==== | ==== Infections: ==== | ||
* Lyme disease | * '''Lyme disease:''' | ||
* syphilis | * '''syphilis:''' | ||
* Progressive multifocal leukoencephalopathy | * '''Progressive multifocal leukoencephalopathy:''' | ||
* HTLV-1 infection | * '''HTLV-1 infection:''' | ||
* Herpes zoster | * '''Herpes zoster:''' | ||
==== Metabolic and genetic disorders: ==== | ==== Metabolic and genetic disorders: ==== | ||
* Vitamin B12 deficiency | * '''Vitamin B12 deficiency:''' | ||
* Lysosomal disorders | * '''Lysosomal disorders:''' | ||
* Adrenoleukodystrophy | * '''Adrenoleukodystrophy:''' | ||
* Mitochondrial disorders | * '''Mitochondrial disorders:''' | ||
* Clinically defined genetic disorders | * '''Clinically defined genetic disorders:''' | ||
==== CNS lymphoma ==== | ==== CNS lymphoma ==== | ||
Revision as of 09:27, 12 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
- Overview
Differentiating multiple sclerosis from other diseases
Multiple sclerosis must be differentiated from other diseases that can mimic this disease clinically or radiologically such as:
Inflammatory/autoimmune conditions:
- systemic lupus erythematosus: Systemic lupus erythromatosus can cause neurological manifestations such as seizures, movement disorders, transverse myelitis, cranial and peripheral neuropathies and optic nerve involvement. In the brain MRI of SLE patients there are evidences of atrophy and subcortical white matter lesions. SLE is diagnosed based on systemic manifestations, present of oligoclonal bands and IgG in CSF and high titer of antinuclear antibodies.
- Sjögren’s syndrome: Sjogren disease can cause neurological manifestations including cerebral vasculitis, myopathy, transvers myelitis and acute optic neuropathy. There are evidence of oligoclonal band and increased IgG in CSF and white matter lesions in MRI. Sicca syndrome, rheumatic manifestation and high titers of ANA,SSRo and SS-La will confirm the diagnosis..
- Vasculitis:
- Behçet’s disease:
- sarcoidosis:
Infections:
- Lyme disease:
- syphilis:
- Progressive multifocal leukoencephalopathy:
- HTLV-1 infection:
- Herpes zoster:
Metabolic and genetic disorders:
- Vitamin B12 deficiency:
- Lysosomal disorders:
- Adrenoleukodystrophy:
- Mitochondrial disorders:
- Clinically defined genetic disorders: